Agimosarid Agimexpharm medicine treats gastritis symptoms (6 blisters x 10 tablets)

Dosage form Box of 6 blisters x 10 tablets
Specifications Mosaprid citrate
Ingredient Vomiting/nausea, gastroesophageal reflux, heartburn

Ingredient

Composition information	Content
Mosaprid citrate	5mg

Uses

indications

Agimosarid drugs are indicated for treating stomach -intestinal symptoms combined with functional indigestion (chronic gastritis), heartburn, nausea, vomiting.

Pharmacokology

Acetylcholine secretion, increased gastric movement. Mosapride is a smooth motor hyperactive drug with chemical structure similar to Metoclopramide. The drug enhances the release of acetylcholine from the end of the nerve after the lymph nodes of the intestinal muscle plexus in the smooth muscle muscle and is the serotonin 5-HT4 receptor receptor. Mosapride increases the pressure of lower esophageal sphincter (stomach and small intestine).

Dynamic pharmacokinetics

mosapride are quickly absorbed after oral, the highest concentration of the drug in the stomach, part of the liver and kidneys. Then distribute with high concentrations in plasma, not distributed to the brain.

In healthy and hungry people, the absorption of drugs is faster.

Plasma peak concentration is achieved after 0.5 hours. Up to 99% Mosapride binds to plasma proteins.

Selling time is 2 hours.

Mosapride is metabolized in the liver by CYP3A4 enzyme of Cytochrome P450, for the main metabolic substance is Des-4-Fluorobenzyl-Mosapride and is excreted mainly in diabetes.

Before taking Agimosarid Agimexpharm medicine treats gastritis symptoms (6 blisters x 10 tablets)

How to use

oral medication. Take medicine before or after eating.

Dosage

Adults: 1 tablet/time x 3 times/day.

Note: The above dose is for reference only. Specific dosage depends on the condition and level of progression of the disease. For a suitable dose, you need to consult a doctor or medical specialist.What to do when overdose?

Symptoms

vomiting, boiling stomach, bloating, great, urination many times.

Treatment

Stomach and/or active carbon use, closely monitor patients and body support treatment.

What to do when you forget a dose? However, if close to the next dose, skip the forgotten dose and take the next dose at the time as planned. Note that it should not be used double the prescribed dose.

Side Effects

When using Agimosarid, you may experience unwanted effects (ADR).

Common, ADR> 1/100

Digestive: diarrhea, abdominal pain, flatulence, dry mouth.

liver: Increase liver enzymes.

nerve: headache, dizziness, dizziness.

Hematology: Eosin hypernagus, leukopenia.

Increase triglycerides.

Uncommon, 1/1000

Systemic: transient headache, dizziness.

digestive: nausea.

Rare, ADR

The whole body: Hypersensitivity reaction, flushing skin, itching, breathing, swelling.

Central nervous system: Symptoms of foreign tapes, epilepsy.

Endocrine: Big breast disease in men, lots of milk.

liver: Increase liver enzymes.

urinary tract: urinate many times.

Note: A few cases have prolonged QT and/or vertices that have been seen in people who have heart disease or risk of arrhythmia.

Instructions on how to handle ADR

Notify the doctor with unwanted effects when using the drug.

Monitoring side effects, especially diarrhea and abdominal spasms.

Need to reduce the dose when seeing diarrhea in young children. If there is abdominal pain, at a dose of 5 mg/kg, the recommended dose for 24 hours should be reduced by half.

Warnings

Before using the drug you need to read the instructions carefully and refer to the information below.

contraindicated

Agimosarid drugs contraindicated in the following cases:

Hypersensitivity to mosapride or other ingredients of the drug.

Gastrointestinal bleeding, digestive mechanical blockage.

Perforated gastrointestinal tract or cases of danger when stimulating the gastrointestinal movement.

Simultaneously with ketoconazole, iTraconazole, miconazole, fluconazole, erythromycin, clarithromycin, troleandomycin and ritonavir.

Patients have a prolonged QT range, patients are at risk of prolonged QT, such as due to reduced potassium or missesi deficiency, or when treated simultaneously with other drugs, can cause an increase in QT.

Be cautious when using

Pregnant women, nursing mothers, premature babies, mechanical clogged symptoms.

When stimulating the digestive tract may be in danger such as obstruction, perforation and gastrointestinal bleeding.

Be cautious when taking medication for patients: heart failure, ventricular arrhythmia (including torsion), transmission defects, local myocardial ischemia, electrolyte disorders, hypokalemia, simultaneous use with rapid reduction of potassium potassium (Furosemide), liver failure.

Be careful when using Mosapride at the same time with drugs that extend QT (process, Quinidine, 3 -round antidepressants).

Parameters to monitor:

Monitoring the serum concentration at the beginning and when stopping treatment because the drug has a narrow treatment.

The ability to drive and operate machinery

Because the drug can cause headaches, dizziness, dizziness, dizziness, it can affect the ability to drive and operate machinery.

Pregnancy

Mosapride is toxic to the fetus of rats and rabbits. There is no enough research on pregnant people. Mosapride should only be used for pregnant women when the treatment is much better than the risk that may occur with the fetus.

The period of breastfeeding

mosapride is excreted through breast milk, so be careful when taking the medication during breastfeeding. Effects on children are not clear.

Drug interaction

mosapride increases the sedative effects of benzodiazepine and alcohol.

Increasing food from the stomach can affect the level of absorption (increase or decrease) other oral medications.

Mosapride may increase blood clotting time in patients taking anticoagulants.

CYP3A4 inhibitors in the liver can significantly increase serum mosapride levels and extend the QT range, leading to ventricular arrhythmia, torsion and even death.

warfarin, diazepam, cimetidine, ranitidine, central neurological inhibitors, erythromycin, macrolide and anti -fungal substances Triazole such as ketoconazole or miconazole increase mosapride levels.

anti -cholinergic drugs: Mosapride can reduce the effects of anti -cholinergic drugs. Therefore, if used with anti -cholinergic drugs, taking these drugs should be spaced for a while.

Storage

Store in a dry place, avoid light, temperature below 30 ° C.

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