Agimycob Agimexpharm Gynecological Pottery Treatment of Vaginitis (1 blister x 10 tablets)

Dosage form Box of 1 blister x 10 tablets
Specifications Metronidazol, nystatin, neomycin
Ingredient Vaginitis, vaginal mushroom, candidia

Ingredient

Composition information	Content
Metronidazol	500mg
Nystatin	100000iu
Neomycin	65000iu

Uses

Indications

Agimycob drugs are indicated in the following cases:

Treatment of vaginitis caused by pathogens.

Pharmacy

The drug has a formula that combines many pharmaceutical substances, thus having the effect on the treatment of vaginitis due to many different causes such as infection, fungal infection, parasitic infection or multiple pathogens at the same time. The drug is combined with the following substances:

metronidazol

Metronidazol is a derivative 5 - nitro - imidazol with a broad activity spectrum on protozoa and anaerobic bacteria. Metronidazol is a very strong drug in the treatment of protozoa as Trichomonas vaginalis and has bactericidal effects on other mandatory anaerobic bacteria.

Metronidazol is used on the spot to treat Trichomonas vaginalis infection.

neomycin

Neomycin is an antibiotic aminoglycosides, sensitive bacteria strains of Neomycin: Staphylococcus aureus, Escherichia coli, Heamophilus Influenza, Klebsiella, Enterobacter of all kinds, neisseria of all kinds. Neomycin is used at the treatment of staphylococcus infections and other sensitive bacteria.

nystatin

is an anti -fungal antibiotic, extracted from streptomyces noursei mushroom culture. Nystatin has the effect of restraining or killing fungi, most sensitive, enamel and very good effects on Candida Albicans. Nystatin has the effect of killing mushrooms (due to contact).

pharmacokinetic pharmacokinetics

metronidazol

After placing it into the vagina, the amount of metronidazole is absorbed into the low blood. The ratio of links with low plasma proteins, less than 20%.

The amount of absorbing drugs is distributed quickly and in the lungs, kidneys, liver, bile, cerebrospinal fluid, skin, saliva, vaginal discharge, it goes through the placenta into breast milk.

metronidazole metabolizes the liver into hydroxy and acid metabolic substances, excreted in urine partially in the form of glucuronid. The metabolites still have some pharmacological effects.

Half lifetime eliminates the average plasma from 8 to 10 hours.

neomycin

Poor absorption, drug absorption may increase when the mucosa is inflamed, or damaged. When absorbed, the drug will quickly eliminate through the kidneys in the form of activity. Half life of the drug is about 2-3 hours.

nystatin

When used on the spot Nystatin is not absorbed through the skin or mucosa.

Before taking Agimycob Agimexpharm Gynecological Pottery Treatment of Vaginitis (1 blister x 10 tablets)

How to use

Medicines for adults by vaginal lines.

Dosage

vaginitis caused by sensitive pathogens and nonsense vaginitis

Vaginal placement 1-2 tablets/day for 10 consecutive days in combination with oral treatment if needed.

Wet the tablet by soaking in water for 20-30 seconds before placing the drug in the vagina. Then continue in about 15 minutes.

Must treat the husband at the same time whether or not there is no clinical signs.

Metronidazol treatment should not be prescribed for more than 10 days and do not repeat more than 2-3 times/year, should not interrupt treatment during the menstrual cycle.

Note: The above dose is for reference only. Specific dosage depends on the condition and level of progression of the disease. For a suitable dose, you need to consult a doctor or medical specialist.

What to do when overdose? However, with products containing other metronidazols, the single dose of up to 12g (oral) has been reported. Symptoms include vomiting, loss of air conditioning and mild loss.
Also in high doses or in the case of prolonged treatment: average leukopenia, peripheral sensory neuropathy has been reported gradually after treatment.
Handling
In case of acute overdose, symptomatic treatment is needed because there is no specific antidote for Metronidazol.
What to do when forgetting 1 dose?

Not recorded.

Side Effects

When using Agimycob, you may experience unwanted effects (ADR).

Rare, 1/1000> ADR> 1/10,000

Gastric disorders, benign digestion: nausea, mouth with metal taste, anorexia, epigastric shrinkage, vomiting, diarrhea.

Very rare

Skin and mucous membranes: allergies (urticaria, itching), flushing, flesh inflammation feels dry mouth.

nerve: headache, dizziness.

Pancreatitis can recover.

High doses or in the case of prolonged treatment

Average leukopenia can recover after stopping the drug.

Peripheral sensory neuropathy: usually from stopping treatment.

Patient urine may be reddish brown due to the presence of water -soluble pigments created by the metabolism of the drug.

Instructions on how to handle ADR

When experiencing side effects of the drug, it is necessary to stop using and notify the doctor or go to the nearest medical facility for timely treatment.

Warnings

Before using the drug you need to read the instructions carefully and refer to the information below.

Contraindicated

Agimycob drugs contraindicated in the following cases:

Hypersensitivity to the ingredients of the drug.

Not recommended: combined with disulfuram or spermicide products.

Caution when using

related to metronidazol:

Metronidazol treatment should not be prescribed for more than 10 days and do not repeat more than 2-3 times/year.

Stop treatment in case of intolerance or allergic reactions or signs such as dizziness, confusion, loss of air conditioning.

Be careful of getting worse in central or peripheral, chronic or progressive patients.

It is necessary to restrain the use of alcoholic drinks during treatment (antabuse effect).

Value of leukemia in patients with a history of hematological disorders, high doses or prolonged treatment.

Metronidazole can cause immobility of Treponema Pallidum to create a false positive reaction of the Nelson test.

Related to neomycin:

Sensitivity to local antibiotics can affect the common use of antibiotics or other antibiotics in the same group.

Treatment time should be limited due to the risk of selection of resistance and superinfection caused by bacteria.

Related to lactose:

This drug contains lactose. If the patient has rare genetic metabolic disorders and galactose tolerance, lactase deficiency or glucose - galactose absorption disorders should not be used.

The ability to drive and operate machinery

Be cautious when using this medication due to the risk of dizziness that may occur, if affected, should not drive or operate machinery.

Pregnancy

The drug containing neomycin is the aminoglycoside antibiotic, which can be toxicated in the ear or enter the bloodstream with a whole body effect, should not use this drug for pregnant women.

Women who are likely to be pregnant or are using contraception should consult a doctor carefully before taking this medication.

There is no information on the toxicity of the fetus.

Breastfeeding period

Because there is no data on the drug in breast milk, do not use this medication during breastfeeding.

Drug interaction

must not be combined with

Sperm killer

All medications for vaginal treatment on the spot can be inactivated in place contraceptive methods with spermicide.

alcohol

Antabuse effect (hot, blushing, vomiting, fast heartbeat). Do not use at the same time with alcoholic drinks or drugs.

disulfuram

can cause paranoia or confusion.

Precautions when combined with

Warfarin oral anticoagulants:

Increases the effect of anticoagulant oral medications and the risk of bleeding due to the loss of catabolism of these drugs in the liver. Should check regularly prothrombin and monitor Inr. Need to adjust anticoagulant oral dose during treatment with Metronidazol and 8 days after stopping treatment.

It should be noted when combined with

5 - Fluorouracil:

Increasing the toxicity of 5 fu due to reducing the clearance of this drug.

Special issues about Inr:

imbalance

Many cases of increased activity of anticoagulants have been reported in patients with antibiotics. The context of infections or vaginal infections is recognized, the age and general condition of the patient showing risk factors. In this case, it seems that it is difficult to distinguish between infection disease and the treatment in the beginning of the ins loss.

However, some more related antibiotics:

Includes fluoroquinolon, macrolid, cyclid, cotrimaxazol and some cephalosporins.

Mutual medicine

Due to the lack of studies on the correlation of the drug, not mixing these drugs with other drugs.

Storage

Cool dry place, avoid light, at temperatures below 30ºC.

Other drugs

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