Agirovastin 10 Agimexpharm reduces cholesterol total cholesterol (3 blisters x 10 tablets)

Dosage form Box of 3 blisters x 10 tablets
Specifications Rosuvastatin
Ingredient High blood fat, high blood cholesterol

Ingredient

Composition information	Content
Rosuvastatin	10mg

Uses

indications

Agirovastin 10 Agimaxpharm 3x10 is indicated in the following cases:

Increasing cholesterol (type IIA including hyperlesty hyperlipidemia heterozygous family) or mixed blood lipid disorders (type IIB):

is a supportive therapy for a diet when the patient does not fully respond to a diet and other non -drug therapies (such as exercise, weight loss).

Hydropectic hypertension of homozygous family type:

Use alone or support for lipid reduction treatments (such as blood ldl excerpts) or when these therapies do not reduce LDL-cholesterol, total cholesterol, and APOB.

Cardiovascular event prophylaxis.

Pharmacology

Rosuvastatin is a selective inhibitor and competition HMG-COA Reductase, which is the 3-Hydroxy-3-Methylutaryl Coenzyme A into Meevalonate, a precursor of cholesterol. The main impact position of rosuvastatin is the liver, the target organs to make cholesterol.

Dynamic pharmacokinetics

Absolute bioavailability of about 20%. The liver is widely distributed in the liver is the main place for cholesterol synthesis and LDL-C clearance. Rosuvastatin is less metabolized (about 10%). CYP2C9 is the main isenzyme involved in metabolism; 2C19, 3A4 and 2D6 participated at a lower level. About 90% of the dose of rosuvastatin are eliminated unchanged through feces (including the active ingredient absorbed and not absorbed) and the rest is excreted into urine.

Before taking Agirovastin 10 Agimexpharm reduces cholesterol total cholesterol (3 blisters x 10 tablets)

How to use

oral medication and one -time daily use, should take the medicine at the same time every day, can take the medicine first, during or after a meal due to the absorption of the drug is not affected by food. However, because the synthesis of cholesterol in the liver occurs mainly at night, taking the drug in the evening will increase the effectiveness of the drug.

You need to follow a standard, low -cholesterol diet before taking rosuvastatin and must continue to maintain this diet during treatment.

Dosage

The recommended starting dose is 5 mg or 10mg x 1 time/day, an increase of the dose every 4 weeks, if necessary, to the dose of 20 mg x 1 time/day.

Dosage and duration of medication depending on your condition. Always take the medication as the doctor. Do not take medicine in more or less or longer or longer than the prescribed dose. Do not stop the drug suddenly without consulting your doctor.

Elderly: The starting dose of 5 mg is used for patients> 70 years old. No dose adjustment in these patients.

Patients with renal failure: No dose adjustment in patients with mild to medium renal failure. Patients with moderate renal impairment (Creatinine clearance

Note: The above dose is for reference only. Specific dosage depends on the condition and level of progression of the disease. For a suitable dose, you need to consult a doctor or medical specialist.

What to do when overdose?

What to do when you forget 1 dose? However, if the time to relax with the next dose is too short, skip the dose and continue the calendar of the drug. Do not use double dose to compensate for missed dose.

Side Effects

When using Agirovastin 10 Agimaxpharm 3x10, you can experience unwanted effects (ADR).

Common, ADR> 1/100:

Digestive: diarrhea, constipation, flatulence, abdominal pain and nausea.

central nervous system: headache, dizziness, blurred vision, insomnia, weakness. nervous - muscle and bone: muscle pain, joint pain. liver: Liver function test results increase more than 3 times on normal.

Uncommon, 1/1,000

Neurological - muscle and bone: muscle disease (combining muscle weakness and increased content of plasma creatin phosphokinase).

DA: Ban Da.

Respiratory: rhinitis, sinusitis, sore throat, cough.

Rare, 1/10,000

Neurological - muscle and bone: muscle inflammation, muscle pilot leads to secondary acute renal failure caused by myoglobin.

Stomach - intestines: pancreatitis

Very rare, ADR

Kidney and urinary: Bleeding.

Instructions on how to handle ADR

When experiencing side effects of the drug, it is necessary to stop using and notify the doctor or go to the nearest medical facility for timely treatment.

Warnings

Before using the drug you need to read the instructions carefully and refer to the information below.

Contraindicated

Agirovastin 10 Agimaxpharm 3x10 contraindications in the following cases:

Hypersensitivity to rosuvastatin or any excipients of the drug

Active liver disease or serum transaminase persistent without explaining.

Severe renal failure (Creatinine clearance

There is muscle disease.

Pregnant or lactating women, women may be pregnant without using appropriate contraception.

Contraindicated dose ≥ 40 mg in the following objects: Asian patients, patients with moderate renal impairment (creatinine clearance

Be cautious when using

Before using this medication, let the doctor know if you have any of the following conditions:

You plan to get pregnant, pregnant or breastfeeding

You have any liver or kidney problems

You have a thyroid problem

You have diabetes, especially diabetes Type 2

Lactose or some other sugar tolerances (because the excipient of this drug has lactose that can be detrimental to you)

The ability to drive and operate machinery

There is no information on the effect of the drug on the ability to drive and use machinery, but it should be noted that side effects such as headache, dizziness, blurred vision may occur.

pregnancy

Do not take this medication if you are pregnant.

The period of breastfeeding

Do not take this medication if you are breastfeeding.

Drug interaction

should avoid using drug groups after using the copper with Agirovastin 10 Agimaxpharm 3x10:

anticoagulant oral medications such as warfarin. Hepatitis C (HCV) such as Atazanavir, Atanzanavir + Ritonavir, Lopinavir + Ritonavir. Rosuvastatin, the plasma rosuvastatin concentration will decrease less.

This list is not full of other drugs that can interact with rosuvastatin. Let your doctor know about all the drugs you are using. Do not take a new medicine without telling your doctor.

While taking this medication, alcohol should be avoided because alcohol can increase triglycerides, and can also cause liver damage when you are using rosuvastatin.

Storage

Leave at temperatures below 30 ° C, avoid moisture and light.

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