Aju Akinol medicine for acne acne (3 blisters x 10 tablets)

Dosage form Box of 3 blisters x 10 tablets
Specifications Isotretinoin
Ingredient Acne

Ingredient

Composition information	Content
Isotretinoin	10mg

Uses

Indications

Aju Akinol is indicated in the following cases:

Treatment of severe acne acne. Therefore stabilizing keratinization and preventing acne formation. The mechanism of action of Isotretinoin is not well known, but maybe it changes the process of DNA codes.

pharmacokinetic

absorption

Due to the high properties of lipids, isotretionine increases absorption when taking the drug with a meal rich in fat. Clinical studies show that there is no difference in pharmacokinetics of isotretinoin in patients with lumpy acne acne and healthy people with normal skin.

Distribution

more than 99.9% isotretinoin associated with plasma proteins, mainly associated with albumin.

Metabolism and elimination

After taking isotretinoin, at least 3 metabolic forms are present in plasma: 4-oxo-isotretinoin, retinoic acid (tretinoin), and 4-oxo-remetinoic acid (4-oxo-tretinoin). Retinoic acid and 13-Cis-Retinoic acid are geometric coins and can be converted with each other. Using this isomers can produce other isomers. Isotretinoin is also not oxidized to 4-oxo-isotretinoin, into geometric isomers 4-oxo-tretinoin.

In vitro studies show that the basic p450 isometric forms are related to the metabolism of isotretinoin, 2C8, 2C9, 3A4, and 2B6. Isotretinoin and its metabolites continue to be metabolized through the conjugate path to excreted into urine and feces.

Before taking Aju Akinol medicine for acne acne (3 blisters x 10 tablets)

How to use

Take oral use.

Dosage

Starting dose

0.5mg/kg/day for 4 weeks.

Maintenance dose

0.1 - 1mg/kg/day depending on the patient.

dose of 1mg/kg/day is the maximum dose should only be used for a limited time.

normal treatment time is 16 weeks. It is possible to start the second treatment if acne is still lumpy. However, between the two treatments, it is necessary to stop taking the drug for at least 8 weeks to evaluate the level of improvement and the need for the next treatment.

In case of low doses, 1 time/day. In case of high doses, isotretinoin is divided into doses a day, drinking during meals.

Note: The above dose is for reference only. Specific dosage depends on the condition and level of progression of the disease. For a suitable dose, you need to consult a doctor or medical specialist.

What to do when overdose? These symptoms can recover. However, gastric lavage should be conducted within hours after high doses.

What to do when forgetting 1 dose? However, if the time to relax with the next dose is too short, skip the dose and continue the calendar of the drug. Do not use double dose to compensate for missed dose.

Side Effects

When using Aju Akinol, you may experience unwanted effects (ADR).

Overdose of vitamin A can dry the mucosa (dry skin, skin damage, itchy, nasal bleeding, dry mouth and dry nose). Hearing disorder can occur.

When experiencing side effects of the drug, it is necessary to stop using and notify the doctor or go to the nearest medical facility for timely treatment.

Warnings

Before using the drug you need to read the instructions carefully and refer to the information below.

Contraindicated

Ain Akinol drugs are contraindicated in the following cases:

Pregnant or suspected pregnant women, nursing women.

Patients with liver and kidney dysfunction.

Patients who overdose vitamin A.

Patients with hyperlipidemia.

Patients with hypersensitivity to this drug and the ingredients of the drug.

Precautions when using

due to the risk of fetal deformities of isotretinoin, so this drug is not used in pregnant women or suspicion of pregnancy, even with small doses in a short time.

If the serum triglyceride level increases in excess of 800mg/dl, acute pancreatitis occurs. Therefore, it is necessary to control the increase in triglycerides in serum. If the serum triglyceride concentration is not controlled or acute pancreatitis occurs, stop taking this medication.

Caution in patients with a history of depression.

Symptoms of acne may be worse in a short time at the beginning of treatment.

Avoid using this medication with drugs to treat epidermis or peeling of skin horns and UV therapy.

Need to test liver function and serum triglyceride level before starting treatment, repeat every 3 months and within 1 month after stopping treatment, especially for people with diabetes, obesity, alcoholism or lipid metabolic disorders.

Should check blood sugar levels in people with diabetes or suspected diabetes.

Do not use progesterone to prevent pregnancy during treatment. Patients should avoid severe skin scratches for 5-6 months, because of the hypertrophic scars.

During treatment, night vision may decrease and recover when stopped treatment.

Caution in patients with a history of intestinal disorders.

The ability to drive and operate machinery

Caution should be cautious when driving at night because the night vision may be reduced during this medication.

Pregnancy

Do not use this drug for pregnant women, suspected pregnancy.

Breastfeeding period

Do not use this medication for nursing women.

Drug interaction

Avoid shared with other drugs containing vitamin A or Tetracycline.

Storage

In closed boxes, avoid light, at temperatures below 30 ° C.

Other drugs

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