Akneyash skin on acne, pustules (30g)

Dosage form Tube x 30g
Specifications Adapalene
Ingredient Yash Medicare PVT.LTD

Ingredient

Composition information	Content
Adapalene	0.1%

Uses

Indications

Apply skin to treat acne when there are many acne, lumpy and pustules. The drug can be used for acne on the face, chest and back.

Pharmacokological

Adapalene is a retinoid derivative used to treat acne. Adapalene is acid 6 [3- (l-adamantyl) -4-methoxyphenyl] -2-naphthoic. Studies in biochemical and pharmacological pharmacology have shown that adapalene regulates cell differentiation, horny and inflammatory processes. All of these processes play an important role in the birth disease. In experiments on regulation of differentiation and regeneration of cells, the drug has shown to be effective.

These effects have also been shown in vivo studies about acne pepper in mice. Adapalene also shows strong anti -inflammatory use in in vivo and in vitro studies. Based on these findings and good tolerance when used on the spot. Adapalene was chosen as acne treatment.

The differential adapalene formulas have been studied to determine the dose, efficiency and optimal safety. Studies show that the supply of adapalene to the sebaceous glands in the pores is improved when used in the form of micro -granular form with a diameter of 310micromet. Cold temperature analysis, radioactive and fluorescent marks on human skin show that Adapalene gel penetrates the epidermis and the dermis good (especially the sebaceous glands).

Micro system provides micro -bridge

Micro system is a system of polymers containing foam particles in the form of micro -bridge made from synthetic polymers. These micro -micro -molecules trap adapalene drug molecules into the micro system. After the preparation is applied to the skin, the drug will be released into the skin with a controlled manner according to a predetermined program.

The micro -bridge releases the drug slowly, causing the skin to absorb the drug a little, thus reducing irritation because the microwave still lies on the skin surface and easily washed when cleaned or washed.

Despite the size of the bridge varies from 5 - 300micromet diameter, a typical 25micromet size has about 250,000 holes and a hole structure equivalent to a length of 10 feet, with a total volume of about 1ml/g, creating a warehouse in the micro -bridge that can contain an amount of drugs equivalent to its mass.

The micro -micro -micro -micro formula contains 3 - 10micromet micro -micro -micro -micro -micro -micro -micro -micro -micro -micro -micro -micro -micro -micro formulas of adapalene trapped in micro -bridge under diameter of 150micromet.

The ability of micro -bridge to the skin depends on granular size. Other studies report that when applying 310pm micro -bridges to the skin will accumulate in hair follicles and sebaceous glands. Adapalene microchips enter the hair follicles and create high concentrations of the drug there. The liberation microorganisms have drug control and provide selective effects, specific and strong on the destination but less irritating to other tissues.

pharmacokinetic

absorption

Low in place is low.

Elimination

mainly excreted through bile. The sale time is 17.2+10.2 hours.

The pharmacokinetics of Adapalene used on the skin have not been studied much. The treatment effect of the drug usually appears within 8 to 12 weeks. Adapalene is less absorbed through the skin, clinical trials only find a small amount (

Before taking Akneyash skin on acne, pustules (30g)

How to use

Apply the skin. Rinse and dry the affected area before applying.

Dosage

ice cream or gel Adapalene should be applied to acne -prone skin once a day before going to bed and after washing your face. A thin layer of drug is applied to acne -prone skin, avoiding contact with the eyes and lips. Pay attention to dry the acne -prone skin before applying the drug.

For patients who need to reduce the number of drugs or temporarily stop treatment, then they can be applied when the patient can continue tolerance.

If the patient uses cosmetics, these products do not cause acne and do not change the skin.

Efficiency and safety of adapalene gel and cream form has not been studied in infants and children.

What to do when overdose? If applying too much, it does not work faster but only causes redness, peeling or other stimuli.

The dose of adapalene -shaped adapalene poisoning or mouse gel is greater than 10g/kg of weight. Unless the amount of oral intake, the appropriate gastric lavage should be considered when oral poisoning occurs.

Overdose

Stop using the drug. With minor adverse reactions, usually just stop the drug. In case of severe sensitivity or allergic reactions, supportive treatment (airy keeping and using epinephrin, oxygen breathing, antihistamine, corticoid ...).

What to do when forgetting 1 dose? However, if the time of relaxation with the next dose is too short, skip the forgotten dose and continue the drug schedule. Do not use double dose to compensate for missed dose.

Side Effects

Unwanted effects mainly include skin irritation, but these symptoms will be lost when reducing the number of drugs or stopping drugs.

Unwanted effects such as erythema, flaking, dry skin, itching and burning can occur.

These unwanted effects usually occur in the first 2-4 weeks of taking the drug, then decreases. Depending on the severity of unwanted effects, patients should reduce the number of drugs or stop using the drug.

Notify your doctor any unwanted effects related to drug use.

Warnings

Contraindications

Do not use Akneyash gel to people sensitive to Adapalene or any ingredients of the drug.

Do not apply medicine to scratched skin (cut or peeled skin), eczema, as well as on patients with severe acne.

Do not use for children under 12 years old, pregnant and lactating women.

Precautions when using

Tanned patients should not take the drug until the skin recovers completely.

If severe irritation occurs after taking the drug, the drug should be stopped. If the irritation is slightly, it is recommended to reduce the number of drugs or temporary suspension until the end of irritation.

Avoid contacting the drug with the face, lips and mucosa. If the cord is on the face, wash immediately with warm water.

Be cautious when used simultaneously with drugs that can cause irritation (soap, detergent, dry cosmetics, products with high alcohol content, hunting agents).

Should use other acne treatment drugs such as erythromycin , Clindamycin, Benzoyl Peroxide in the morning and use adapalene in the evening.

Limit exposure to sunlight while using Adapalene. In case of mandatory exposure to sunlight, sunshades should be used.

The effect of the drug does not increase when increasing the dose but may be red, peeling or discomfort. If the patient has a skin peeling before starting with Adapalene, should wait for the skin to recover completely before taking the medication.

The ability to drive and operate machinery

Akneyash does not affect the ability to drive and operate machinery.

Pregnancy and lactation

Pregnancy

There are no equivalent studies and well controlled related to the use of adapalene for pregnant women. Do not use adapalene for pregnant women.

Breastfeeding period

Do not use adapalene for breastfeeding people.

Drug interaction

Do not know the drug interactions with other drugs when used on the skin with Adapalene. However, other retinoids or other drugs have the same mechanism of action should not be used simultaneously with Adapalene.

Absorb adapalene through low skin, so there is no interaction with other drugs in the body.

There is no evidence that the effectiveness of oral medications such as birth control pills or antibiotics is affected by adapalene bumper.

Adapalene has the ability to cause mild irritation at the top -site and therefore can be combined with exfoliating, skin or skin stimulation can increase skin irritation effect. However, acne treatments on the skin, such as erythromycin (up to 4%) or clindamycin phosphate solution (1%base) or gel benzoyl peroxide up to 10%, can be used in the morning while adapalene cream or gel is used in the evening due to non -causing degeneration or causing irritation.

Storage

Store in closed packaging at temperatures below 30 ° C. Do not freeze.

To stay out of reach of children.

Other drugs

Disclaimer

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