Alaxan United medicine reduces musculoskeletal pain, headache, dysmenorrhea, toothache (10 blisters x 10 tablets)

Dosage form Tablet
Specifications Box of 10 blisters x 10 tablets
Ingredient Paracetamol, ibuprofen

Ingredient

Thành phần cho 1 viên

Composition informationContent
Paracetamol325mg
Ibuprofen200mg

Uses

indications

alaxan drugs are indicated in the following cases:

  • Reduce mild to moderate muscular muscle pain such as neck pain, shoulder pain, back pain, muscle tension or calf, stiff neck, arthritis, rheumatism, epidemic inflammation, sprain, tendonitis. How to inhibit prostaglandin synthesis.

    Pain relievers by increasing pain and fever -reducing threshold through impact on the hypothalamus central center. At the dose of treatment, paracetamol analgesics are equivalent to acetylsalicylic acid. Paracetamol does not affect the disadvantage of platelet function and coagulation.

    ibuprofen is a derivative from propionic acid, which has analgesic, anti -inflammatory and antipyretic. As a nonsteroidal anti -inflammatory (NSAID), ibuprofen has the effect of inhibiting cyclooxygenase enzyme, reducing prostaglandin synthesis.

    ibuprofen is considered to be the safest among nonsteroidal anti -inflammatory drugs. The drug has good anti -inflammatory and analgesic effect in the treatment of teenagers.

    Dynamic pharmacokinetics

    paracetamol

    absorption: Paracetamol is absorbed quickly and completely after drinking. The peak concentration of plasma is about 30–60 minutes after drinking.

    Distribution: About 25% paracetamol in the blood combined with plasma proteins.

    Metabolism: Paracetamol is metabolized mainly in the liver.

    Elimination: The total clearance of the body is about 5 ml/kg/min. Kidney clearance is about 10 ml/min, depends on the rate of urine and does not depend on pH.

    ibuprofen

    absorption: Ibuprofen is quickly absorbed in the gastrointestinal tract and the peak concentration in plasma is about 1–2 hours after drinking.

    Distribution: Ibuprofen is strongly connected to plasma proteins.

    Elimination: The sale time is about 2 hours. The drug is quickly excreted in the urine, about 1% is excreted in the urine in the form of unchanged and about 14% in the form of conjugated ibuprofen.

    • Before taking Alaxan United medicine reduces musculoskeletal pain, headache, dysmenorrhea, toothache (10 blisters x 10 tablets)

    How to use

    oral medication.

    Do not use longer than 10 days without a doctor's instructions.

    Dosage

    Adults: Take 1 tablet every 6 hours when needed, or according to the doctor's instructions.

    Not for children under 12 years old.

    Elderly: Using the lowest dose in the shortest possible time. Should regularly monitor the side effects of the drug.

    Patients with impaired liver and kidney function: Unwanted effect will be minimized when using the lowest dose has the effect.

    Note: The above dose is for reference only. Specific dosage depends on the condition and level of progression of the disease. For a suitable dose, you need to consult a doctor or medical specialist.What to do when overdose? Treatment includes stomach lavage. N-acetylcysteine ​​is an effective antidote if it starts within 10–12 hours after overdose, but N-acetylcysteine ​​still works if treated within 24 hours.

    What to do when you forget a dose? However, if close to the next dose, skip the forgotten dose and take the next dose at the time as planned. Note that it should not be used double the prescribed dose.

    Side Effects

    When using alaxan, you may experience unwanted effects (ADR).

    ibuprofen:

    Common, ADR> 1/100

  • Body: Fever, fatigue;
  • digestive: bloating, nausea, vomiting;
    • nerve: headache, dizziness, restlessness;
  • Skin: itchy, foreign rash.

    • Uncommon, 1/1000

  • Allergic reactions (bronchospasm in people with asthma), rhinitis;
    • skin: urticaria; digestive: abdominal pain, progressive stomach ulcers, stomach bleeding;

    Neurological: Drinking, insomnia; ears: tinnitus, hearing loss;

  • eyes: visual disorders;
  • Prolonged bleeding time.

    • Rare, ADR

  • Skin: edema, rash, Stevens - Johnson syndrome, hair loss;
    • nerve: depression;

    Aseptic meningitis;

  • Eye: blurred vision;
    • Blood: leukopenia, platelet reduction, neutropen leukemia, Eosin hypernephastal hyperactivity, anemia; liver - Most: gallbladder disorders, abnormal liver function, liver toxicity; kidney: cystitis, blood, acute renal failure, interstitial nephritis, nephrotic syndrome; cardiovascular: The risk of cardiovascular thrombosis.

    paracetamol:

    Uncommon, 1/1000

  • DA: Ban Da;
    • digestive: nausea, vomiting; blood: Hemorrhagic disorders (neutropenia, all bloody hemocytes, leukopenia), anemia;
  • kidney: Kidney toxicity when abusing for a long time.

    • Rare, ADR

  • Hypersensitivity reaction.

    • Instructions on how to handle ADR

    When experiencing side effects of the drug, it is necessary to stop using and notify the doctor or go to the nearest medical facility for timely treatment.

    Warnings

    Before using the drug you need to read the instructions carefully and refer to the information below.

    contraindicated

    Alaxan medicine is contraindicated in the following cases:

  • Hypersensitivity to paracetamol, ibuprofen or any ingredients in excipients.

    • paracetamol:

  • Patients with many anemia or heart, lung, kidney, liver disease.
  • Patients with glucose-6-phosphate dehydrogenase deficiency.

    • ibuprofen:

  • Patients with a history of hypersensitivity (bronchospasm, asthma, angioedema, rhinitis, urticaria) associated with acetylsalicylic acid or other NSAIDs;

    • Progressive peptic ulcer;

    Preventy of ulcer/peptic or recurrent ulcers related to NSAID;

  • Patients with liver failure, kidney failure or severe heart failure;
  • Patients being treated with anticoagulant drugs;
  • Patients with congestive heart failure, glue disease;
  • The last 3 months of pregnancy.

    • Be cautious when using

    paracetamol:

    Use paracetamol caution in patients with severe impaired liver and kidney function. The risk of overdose is more dangerous in people with alcoholic liver disease without cirrhosis.

    Do not take it with other drugs containing paracetamol.

    Notify the doctor immediately if the paracetamol overdose is overdose because it will cause liver damage. Severe liver damage can occur if drinking more than 4 g paracetamol in 24 hours.

    Paracetamol is associated with the risk of serious skin reactions.

    Doctors need to warn patients on signs of serious skin reactions such as Stevens - Johnson syndrome, poisoned epidermal syndrome or Lyell syndrome, and acute overseas pustules syndrome. When detecting signs of the first skin rash or any other signs of fruit reactions, patients need to stop using the drug.

    ibuprofen:

    Be careful in the following patients:

  • Lupus erythematosus body as well as mixed tissue disease due to increased risk of sterile meningitis.
  • Gastrointestinal disorders and chronic intestinal diseases (ulcerative colitis, Crohn disease).
  • Patients with a history of hypertension and/or heart failure.
  • impaired renal function, liver dysfunction.
  • Bronchospasm can occur in patients with a history of bronchial asthma or allergies.
  • Simultaneously used NSAIDs including Cycloxygenase-2.

    • Cardiovascular disease and cerebrovascular disease:

  • Clinical research shows that the use of ibuprofen, especially at high doses (2400 mg/day) may increase the risk of arterial thrombosis (myocardial infarction or stroke).

    • Risk of cardiovascular thrombosis: nonsteroidal anti -inflammatory drugs (NSAIDs), not aspirin, using systemic sugar, can increase the risk of cardiovascular thrombosis, including myocardial infarction and stroke, which can lead to death. This risk can appear early in the first few weeks of taking the drug and can increase over time. The risk of cardiovascular thrombosis is recorded mainly at high doses.

    Doctors need to periodically evaluate the appearance of cardiovascular events, even if the patient does not have previous cardiovascular symptoms.

  • Patients should be warned of symptoms of serious cardiovascular events and need to visit a doctor as soon as they appear these symptoms. In order to minimize the risk of adverse incidents, it is necessary to use alaxan at the lowest daily doses in the shortest possible time as possible.
  • Intensive hypertension patients, congestive heart failure (NYHA II-III), ischemia heart disease, peripheral artery disease, and/or cerebrovascular disease should be treated with ibuprofen after careful consideration and no high doses (2400 mg/day).

    • Be cautious before starting long -term treatment in patients with cardiovascular risk factors (hypertension, hyperlipidemia, diabetes, smoking), especially if you need high doses of ibuprofen.

    There are some evidence that cyclooxygenase synthesis or synthesis inhibitors can reduce fertility in women due to ovulation.

    Gastrointestinal bleeding, ulcers or gastrointestinal perforation can be fatal, which has been reported to all NSAIDs, with or without warning symptoms or a pathology of pathology (colic ulcer, Crohn's disease).

    Be cautious when treating simultaneously with drugs that may increase the risk of gastrointestinal toxicity or bleeding, such as corticosteroids, anticoagulants (warfarin), selective Serotonin reabsorption inhibitors or plateletic anti -coast drugs (Aspirin).

    Serious skin reactions are rare such as all over the body, Stevens - Johnson syndrome, poisoned epidermal necrosis. Ibuprofen should be discontinued when the first skin appears, mucosal damage or any hypersensitivity signs.

    There is a risk of reducing kidney function due to dehydration in children and teenagers 12–18 years old.

    Colonel: The drug contains lactose. Patients with rare genetic problems such as galactose intolerance, complete deficiency of lactase enzymes or Glucose - Galactose should not use this drug.

    The ability to drive and operate machinery

    Unwanted effects such as dizziness, fatigue, drowsiness and visual disorders that can occur when taking nonsteroidal anti -inflammatory drugs. If affected, patients should not drive or operate machinery.

    Pregnancy

    paracetamol: No contraindication to use paracetamol in pregnant women, but patients need to consult a doctor when taking the drug.

    ibuprofen: Although not teratogenic in experimental animals, if possible, should be avoided in the first 6 months of pregnancy. Do not take the drug in the last 3 months of pregnancy because of the risk of early closing the arterioscleria in the fetus in the uterus and may cause persistent hypertension in the newborn. Labor slow and prolonged, increased the risk of bleeding in both mother and fetus.

    Breastfeeding period

    paracetamol: Excreted in breast milk with very low amounts. There is no clinical data on contraindications for using paracetamol during breastfeeding.

    ibuprofen: Very little breast milk, insignificant. It is likely to occur risks for children at normal doses with mothers.

    Drug interaction

    paracetamol:

  • cholestyramine: reduces the absorption of paracetamol.
  • Paracetamol metabolic stimulus drugs as medications for seizures can increase the harmful effects on the liver.

    • ibuprofen:

  • Other NSAIDs including selective inhibition of COX-2 may increase the risk of side effects. Dong. Diuretics increase the risk of kidney toxicity on NSAID's kidneys.
  • corticosteroid: Increased risk of stomach ulcers or bleeding.
  • Zidovudine: Increased risk of blood poisoning.

    • Storage

    Store at a temperature not exceeding 30ºC.

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