Alaxan United medicine reduces musculoskeletal pain, headache, dysmenorrhea, toothache (25 blisters x 4 tablets)

Dosage form Tablet
Specifications Box of 25 blisters x 4 tablets
Ingredient Paracetamol, ibuprofene

Ingredient

Composition information	Content
Paracetamol	325mg
Ibuprofene	200mg

Uses

indications

alaxan drugs are indicated in the following cases:

Reduce mild to moderate muscle muscle pain such as neck pain, shoulder pain, back pain, muscle tension or calf, stiff neck muscle, arthritis, rheumatism, epidemic inflammation, sprain, tendonitis.

Hearing headache, dysmenorrhea, toothache, after tooth extraction and minor surgery.

Pharmacology

paracetamol

Paracetamol has analgesic and antipyretic effects by inhibiting prostaglandin synthesis. Pain relievers are increased by increasing pain and antipyretic threshold through impact on the center of thermostats in the hypothalamus. At the dose of treatment, paracetamol analgesics are equivalent to acetylsalicylic acid. Paracetamol does not affect the disadvantage of platelet function and coagulation.

ibuprofen

ibuprofen is a derivative from propionic acid, which has analgesic, anti -inflammatory and antipyretic. The therapeutic effect of the drug, as an nonsteroidal anti -inflammatory (NSAID), ibuprofen has the effect of inhibiting cyclooxygenase enzyme, resulting in reducing prostaglandin synthesis. Ibuprofen is considered to be the safest drug among nonsteroidal anti -inflammatory agents. Drugs have good anti -inflammatory and analgesic effects in the treatment of teenage rheumatoid arthritis.

Dynamic pharmacology

paracetamol

absorption:

Paracetamol is absorbed quickly and completely after drinking. The peak concentration of plasma is about 30–60 minutes after drinking.

Distribution:

About 25% Paracetamol in the blood combined with plasma proteins.

Metabolism:

paracetamol is metabolized mainly in the liver.

Era:

The total clearance of the body is about 5 ml/kg/min. Kidney clearance is about 10 ml/min, depends on the rate of urine and does not depend on pH.

ibuprofen

absorption:

ibuprofen is quickly absorbed in the digestive tract and the peak concentration in plasma is about 1–2 hours after drinking.

Distribution:

ibuprofen is strongly linked to plasma proteins.

Era:

Selling time is about 2 hours. The drug is quickly excreted in the urine, about 1% is excreted in the urine in the form of unchanged and about 14% in the form of conjugated ibuprofen.

Before taking Alaxan United medicine reduces musculoskeletal pain, headache, dysmenorrhea, toothache (25 blisters x 4 tablets)

How to use

Take oral use.

Do not use longer than 10 days without a doctor's instructions.

Dosage

like other nonsteroidal anti -inflammatory drugs, Ibuprofen + paracetamol should be used in the lowest doses in the shortest time that is effective.

Adults and children aged 12 years and older: Take 1 tablet every 6 hours when needed, or according to the doctor's instructions.

Note: The above dose is for reference only. Specific dosage depends on the condition and level of progression of the disease. For a suitable dose, you need to consult a doctor or medical specialist.

What to do when overdose?

i. Disorders of eating, nausea, vomiting, discomfort, and bad tissue.

II. Pain or touching pain in the upper right abdomen; The liver is manifested by the feeling of this abdomen, increased liver enzymes and bilirubin in the blood, the long prothrombin time, and sometimes reduces the amount of urine.

III. Symptoms of eating disorders, nausea, vomiting, discomfort, signs of liver failure and may have renal failure.

IV. Recovery or progress to completely fatal liver failure.

The most common symptom of the ibuprofen dose includes abdominal pain, nausea, vomiting, fatigue, and drowsiness. Other symptoms are headache, tinnitus, central nervous system inhibitors, convulsions. Metabolic acidosis, coma, acute renal failure, apnea rarely occur.

If the patient has used an overdose, consult the doctor immediately.

Treatment includes gastrointestinal cattle. N-acetylcysteine is an effective antidote if it starts within 10-12 hours after overdose; However, N-acetylcystaina still works if treated within 24 hours.

What to do when forgetting a dose? Do not use double the prescribed dose.

Side Effects

When using Alaxan drugs, you may experience unwanted effects (ADR). Ibuprofen + paracetamol has little side effects when used in doses and recommendations.

ibuprofen:

Common, ADR> 1/100:

Body: Fever, fatigue;

Digestive: bloating, nausea, vomiting;

Neurology: headache, dizziness, restlessness;

Skin: itchy, foreign.

Uncommon, 1/1000

Allergic reactions (bronchial spasms in people with asthma), rhinitis;

skin: urticaria;

Digestive: abdominal pain, progressive stomach ulcers, stomach bleeding;

Neurology: Drinking, insomnia;

ears: tinnitus, hearing loss;

Eyes: visual disorders;

Other: prolonged bleeding time.

Rare, ADR

Skin: edema, rash, stevens - johnson syndrome, hair loss;

Neurology: depression;

Eyes: blurred vision;

Blood: leukopenia, thrombocytopenia, neutropenia, eosinophilia loves eosin, anemia;

Hepatoosa: abnormal liver function, liver poisoning;

Kidney: cystitis, blood urine, acute renal failure, interstitial nephritis, nephrotic syndrome.

paracetamol :

Uncommon, 1/1000

DA: Ban Da.

Gastrointestinal: Mild gastrointestinal disorders.

Instructions on how to handle ADR:

When experiencing side effects of the drug, it is necessary to stop using and notify the doctor or go to the nearest medical facility for timely treatment.

Warnings

Before using the drug you need to read the instructions carefully and refer to the information below.

contraindicated

Alaxan medicine is contraindicated in the following cases:

allergies to the composition of the drug, aspirin, other nsAIDs;

progressive peptic ulcer;

Liver failure, kidney failure;

asthma, bronchospasm;

Cardiovascular disease;

bleeding disorders.

Be cautious when using

If the symptoms of liver abnormalities appear, stop taking the medication and consult your doctor.

The risk of a heart attack or a stroke may increase if the drug is taken more or more for a longer time than the recommended dose.

Consult your doctor before use if the patient:

There is a problem or a serious side effect due to analgesics or fever.

is taking another drug.

Consult your doctor before use if:

Warnings and gastric hemorrhage are in accordance with the patient's condition.

Stop taking the drug for consulting the doctor if:

Patients with any symptoms of the following stomach bleeding: tired; vomiting blood, walking black or bloody stool; Symptoms of stomach pain do not get better.

Warning

Allergy warning:

ibuprofen can cause severe allergic reactions, especially in aspirin allergies.

If allergic, stop taking the drug and see a doctor immediately.

Warning of gastric hemorrhage:

The drug contains nonsteroidal anti -inflammatory drugs, which can cause serious stomach bleeding. If you are uncomfortable in the stomach, it is wasted with food or milk.

Serious skin reaction:

Paracetamol is associated with several risks of rare serious skin reactions. The doctor needs to warn the patient about the signs of serious skin reactions. Such as Stevens Johnson (SJS) syndrome, toxic skin necrosis syndrome (Ten) or Lyell syndrome, and acute non -acne pustules syndrome (AGEP). When detecting signs of rash on the first skin or any other hypersensitive reactions, patients need to stop using the drug.

Liver warning:

Paracetamol -containing drugs. Severe liver damage may occur if:

Take more than 4g paracetamol for 24 hours, this is the maximum daily dose.

Take with other drugs containing paracetamol (or acetaminophen).

Take 3 cups of alcohol or more every day while taking this medicine.

Do not use with other drugs containing paracetamol (prescription or prescription drugs).

Do not take this drug:

right before or after heart surgery.

If the patient has a history of stroke, heart attack, uncontrolled high blood pressure, congestion.

If patients have angioedema, nasal polyps or allergic reactions when taking aspirin or other nonsteroidal anti -inflammatory drugs.

If the patient has bleeding disorders.

Avoid long -term medication in patients with anemia.

The ability to drive and operate machinery

Unwanted effects such as dizziness, fatigue, drowsiness and visual disorders that can occur when taking nonsteroidal anti -inflammatory drugs. If affected, patients should not drive or operate machinery.

Pregnancy

If the patient is pregnant, consult a doctor before taking the medication. Especially, Ibuprofen is not used in the last three months of pregnancy.

Lactation period

If the patient is breastfeeding, consult a doctor before use.

Drug interaction

Aspirin reduces the amount of ibuprofen in the blood, while phenylbutazone, indomethacine, salicylate ... increase the risk of gastric bleeding in patients using iburofen.

ibuprofen increases the amount of lithium in the blood may be due to lithium secretion.

ibuprofen can reduce acute kidney energy and reduce blood pressure response to enzyme inhibitors.

ibuprofen can reduce the effectiveness of diuretics such as Furosemid and Thiazide.

When used with anticoagulants, or medications that soluble thrombosis, ibuprofen can cause stomach bleeding.

paracetamol increases anticoagulant effects of warfarin.

Paracetamol metabolic stimulants are responsible for triggling, such as convulsions that can increase harmful effects on the liver.

Storage

Store at a temperature not exceeding 30ºC.

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