Albendazol Stella 400mg medicine for one or more intestinal parasites (1 blister x 1 tablet)

Dosage form Box of 1 blister x 1 tablet
Specifications Albendazole
Ingredient Liver fluke infection, roundworm infection, needle wormworm, squeeze infection, hairworm infection, hookworm infection

Ingredient

Composition information	Content
Albendazole	400mg

Uses

indications

Albendazole Stella 400 mg is indicated in the following cases:

Treatment of an infection or many types of intestinal parasites such as roundworms (Ascaris lumbricoides), needleworms (enterobius vermicularis), hookworm (Ancylostoma duodenale), Mine worms (Necator Americanus), Hairworm (Trichuris Trichuriurura), Eelworm (Strongyloides stercoral) (Hypenolepis Nana), Ta Pork (Taenia Solium), T. Saginata), Opisthorchis vietrini and O. Sinensis.

Albendazole is also effective on immigrant larvae.

The drug also works for tapeworm larvae with brain damage.

Treatment of cases of non -surgical cysts, but the long -term benefit of this treatment must be further evaluated.

Pharmacokology

Pharmacological group: Round worm treatment, benzimidazol.

Code ATC: P02CA03

Albendazole is a derivative of benzimidazol carbamat, in terms of structure related to Mebendazol. The drug has a broad -active spectrum on intestinal worms such as hookworms (Ancylostoma duodenale), mine worms (Necator Americanus), roundworm (Ascaris lumbricoides), needle worms (Enterobius vermicularis), eelworm (Strongyloides stercoralis),

hairworm Albendazole is active in both adult and larvae stage of intestinal worms and eliminates the eggs of roundworms and hair worms. The main metabolic form of Albendazole is Albendazole Sulfoxyd still works and holds an important position in terms of pharmacological effects of the drug.

The mechanism of action of albendazole is similar to other benzimidazols. The drug is associated with the sub -parasite's sub -parasites, thereby inhibiting the coincidence of the sub -sub -trailers into the minor microorganisms of the cytoplasmic cells that are essential for the normal activity of the parasitic cell.

Dynamic pharmacokinetics

In humans, after drinking, Albendazole is very poorly absorbed (

Due to a very strong step metabolism, the albendazole is not seen or only seen in the form of plasma traces. After taking a single dose of 400 mg of albendazole, the peak concentration of the sulfoxyd metabolites achieved in plasma is about 0.04 - 0.55 micrograms/ ml after 1 to 4 hours. When taking the drug with fat foods, plasma concentrations increased to 2-4 times. There is a great difference between individual concentrations of albendazole sulfoxyd in plasma. It may be due to erratic absorption and due to the difference in the speed of drug metabolism.

Albendazole sulfoxyd binds to protein in plasma up to 70%. When used for long -term use in the treatment of tapeworms, the concentration of albendazole sulfoxyd in tapeworms can reach about 20% of plasma concentrations. Albendazole sulfoxyd through the brain blood barrier and concentration in brain - marrow is about 1/3 of plasma concentrations.

Albendazole is rapidly oxidized and completely into a metabolic substance that still works, Albendazole Sulfoxyd, then converted into a compound that no longer works as Albendazole Sulfon.

Albendazole Sulfoxyd has a half -life from plasma for about 9 hours. Sulfoxyd metabolites are eliminated through the kidneys along with sulfon metabolites and other metabolites. A negligible amount of sulfoxyd metabolites excreted through bile.

Before taking Albendazol Stella 400mg medicine for one or more intestinal parasites (1 blister x 1 tablet)

How to use

chew tablets and drink with a glass of water, or crush pellets and mix with food. No need to fast or last.

Dosage

roundworm, needle worm, hookworm or hair worm:

Adults and children over 2 years: The same dose: 400 mg orally 1 doses in 1 day. Can be treated after 3 weeks.

Children until 2 years old: 200 mg 1 single dose for 1 day. Can be treated after 3 weeks.

Larvae in the skin:

Adults: Take 400 mg, take 1 time, take 3 days.

Children: Take 5 mg/ kg/ day, take 3 days.

Folliculi:

Adults: Take 800 mg per day, divided into 2 times, for 28 days. Treatment can be repeated after 2-3 weeks if necessary, sometimes up to 2 or 3 treatments. If the tapeworm does not surgery, can be up to 5 times.

Children 6 years and older: Take 10 -15 mg/ kg/ day, for 28 days. Treatment can be repeated if necessary.

Children until 6 years of age: The dosage has not been identified.

Tapeworm larvae in the brain:

Adults: 15 mg/ kg/ day for 30 days. Treatment can be repeated after 3 weeks.

Children: See adult dose.

tapeworms, melon seeds, eelworms:

Adults: Take 400 mg/ day/ time, for 3 days. Treatment can be repeated after 3 weeks.

Children 2 years and older: The dose of adults.

Children until 2 years old: take 200 mg/ kg/ day, for 3 consecutive days. Treatment can be repeated after 3 weeks.

Note: The above dose is for reference only. Specific dosage depends on the condition and level of progression of the disease. For a suitable dose, you need to consult a doctor or medical specialist.

What to do when using overdose?

What to do when you forget a dose? However, if close to the next dose, skip the forgotten dose and take the next dose at the time as planned. Do not drink twice as prescribed.

Side Effects

When using Albendazole Stella 400 mg, you may experience unwanted effects (ADR).

When treating for a short time (no more than 3 days), some cases are uncomfortable in the gastrointestinal tract (epigastric pain, diarrhea) and headache.

In the treatment of tapeworm or tapeworm larvae with brain damage are cases of high and long -term doses, harmful effects are more common and worse.

Usually unwanted effects are not severe and recover without treatment. Only stop treatment when leukocyte or liver abnormalities.

Common (1/100 ≤ ADR

Systemic: Fever;

Central nervous system: headache , dizziness, brain manifestation, increased pressure in the brain; liver: abnormal liver function; stomach - intestines: abdominal pain, nausea, vomiting;

Skin: Hair loss (recovery).

Uncommon (1/1,000 ≤ ADR

Systemic: allergic reactions;

blood: leukopenia; DA: Ban Da, urticaria ; kidney: Acute renal failure.

Rare (1/10,000 ≤ ADR

Blood: Autics of granulocytes, all bloody hemolysis, grain leukemia, thrombocytopenia.

Instructions on how to handle ADR:

When experiencing side effects of the drug, it is necessary to stop using and notify the doctor or go to the nearest medical facility for timely treatment.

Warnings

Before using the drug you need to read the instructions carefully and refer to the information below.

Contraindicated:

Albendazole Stella 400 mg contraindicated in the following cases:

Patients with a psychic of the benzimidazol group or any ingredients of the drug (excipients: lactose monohydrate, corn starch, microcrystallin cellulose, sodium lakyl sulfate, Povidon K3O, sodium Glycolat, Aspartam, Magnesi Stearate, Fruit Powder, Hypromellol, MacRomellolol, MacRomellololose 6000, Talc, Titan dioxyd.).

Patients with a history of bone marrow poisoning.

Pregnant women.

Be cautious when using

patients with abnormal liver function before starting treatment with albendazole need to consider carefully because the drug is metabolized in the liver and has seen a few people with liver poisoning. Also be cautious for people with blood.

Albendazole Stella 400 mg contains lactose. This drug should not be used for patients with rare genetic problems galactose intolerance, total lactase enzyme deficiency or glucose - galactose.

Albendazole Stella 400 mg contains aspartam. Aspartam is a source of phenylalanin, which can be harmful to patients with phenylketonuria (PKU), a rare genetic disorder causing phenylalanin accumulation because the body cannot be appropriately eliminated.

The ability to drive and operate machinery

unknown.

Pregnancy

should not use albendazole for pregnant women except for cases of mandatory use without any other way. Patients must not be pregnant for at least one month after using albendazole. If the patient is taking the drug and if he is pregnant, he/she must stop the drug immediately and must understand that the drug can cause serious danger to the fetus.

The period of breastfeeding

is unknown how much the medicine is in the milk. Therefore, it is necessary to be very careful when using albendazole for nursing women.

Drug interaction

dexamethason: The lowest stable concentration in the plasma of Albendazole Sulfoxyd is about 50% higher when used in combination with 8 mg of dexamethasone with each dose of Albendazole (15 mg/ kg/ day).

Prazancelel : Prazancelel (40 mg/kg) increases the average concentration in plasma and area under the curve of Albendazole Sulfoxyd about 50% compared to using Albendazole alone (400 mg).

cimetidin: Albendazole sulfoxyd concentration in bile and in fluid fluid increased by about twice in people with folliculum when used in combination with cimetidine (10 mg/ kg/ day) compared to using albendazole lone (20 mg/ kg/ day).

Theophylin : The pharmacokinetics of theophylin (transmitted for 20 minutes aminophyllin 5.8 mg/kg) unchanged after taking 1 dose of Albendazole (400 mg).

Cavalry of the drug: Due to no studies on the correspondence of the drug, not mixing this drug with other drugs.

Storage

Store in closed packaging, dry place, avoid light. The temperature does not exceed 30 ° C.

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