Albendazole Stada 200mg Treatment of one or more intestinal parasites (1 blister x 2 tablets)

Dosage form Box of 1 blister x 2 tablets
Specifications Albendazole
Ingredient Infection with liver fluke, parasites

Ingredient

Composition information	Content
Albendazole	200mg

Uses

indications

Albendazol 200 mg drugs are indicated in the following cases:

Taenia Solium larvae (Taenia solium) in the nervous system (inside or outside the nerve parenchyma). (Ancylostoma Duodenal and Necator Americanus), Hairworm (Trichuris Trichiura), SEL Worms (Strongyloides Stercoralis), Needworms (Enferobius Vermicularis) and thread worms (Mansonella Perstants, Wucheria Bancrofti). Canis or T. Cati.

The disease caused by Giardia. The drug is used to treat tapeworm larvae caused by Cysficercus cellulosae in nerve parenchyma and tapeworm caused by echinococcus granulosus. The drug has a broad -active spectrum on intestinal worms such as roundworms (Ascaris lumbricoides), hookworms (Ancylostoma duodenal and Necator Americanus), Hairworm (Trichuris Trichiura), eel worm (Strongyloides stercoralis), needle worms (Enferobius vermicularis), Capillaria (Capillaria (Capillaria Bun Philippinensis) and twisted worms (Trichinella Spiralis). Albendazole also works for migration larvae in the skin.

The mechanism of action of albendazol has not been fully known. The drug has a strong, specific affinity attached to Beta - Tubulin (a free protein) in the cells of the parasite, thereby inhibiting the coincidence into the minor microorganisms of the cells that are essential for normal activity of parasitic cells, while inhibiting the absorption of glucose of parasites at larvae and adult larvae, leading to exhaustion of Glycogen and deadly parasites. Albendazole has the effect of killing the larvae of Necator Americanus hookworms and cosaic eggs, hookworms, hairworms.

Pharmacokinetics

absorption

Albendazole is very poorly absorbed through the digestive tract, but the absorption will increase significantly when used with fat foods.

Distribution

The drug is widely distributed in the body's fluid, into cerebrospinal fluid, tapeworm, liver, serum, urine. Links to high plasma proteins (70%).

Metabolism and elimination

Fast and strong metabolism through the liver step one to form the active metabolic substance, Albendazol Sulfoxid, which has a sufficient concentration to detect in plasma. Albendazole is also converted into 6 - hydroxy sulfoxid and sulfon, but the concentration is not enough to detect in plasma.

After taking a single dose of 400 mg of albendazol, the peak concentration of the active metabolites is Albendazol Sulfoxid achieved in plasma about 0.46 - 1.58 micrograms/ml after 2 to 5 hours, the sale time is 8 - 12 hours. Similarly, if one dose is 15 mg/kg, the peak concentration of Albendazol Sulfoxid in plasma is about 0.45 - 2.96 micrograms/ml after 4 hours, the sale time is 10 - 15 hours. A negligible amount of sulfoxid metabolism is excreted through bile.

Before taking Albendazole Stada 200mg Treatment of one or more intestinal parasites (1 blister x 2 tablets)

How to use

Albendazol 200 mg can chew, swallow or grind and mix with food. No need to fast or eraser.

Dosage

Cysticercus cellulosae tapeworm disease in the nerve tissue

Adults and children over 6 years old, weighing> 60 kg: 400 mg/time x 2 times/day with food for 8 - 30 days.

For people weighing

No dose for children under 6 years old.

Echinococcus granulosus (surgical treatment)

The dose as above, but a 28 -day treatment, repeated after 14 days off, so on the treatment of 3 consecutive times.

Adults and children over 2 years old: 400 mg oral 1 doses in 1 day. Can repeat after 3 weeks.

Children until 6 years old: 200 mg 1 single dose for 1 day. Can repeat after 3 weeks.

Children until 6 years of age: Unmetved dosage.

Strongyloides

Adults and children over 2 years: 400 mg/time/day, drink for 3 days. Can repeat after 3 weeks.

Children until 2 years: 200 mg/time/day, drink for 3 days. Can repeat after 3 weeks.

Capillaria worms

Adults and children: 200 mg/time x 2 times/day for 10 days.

Adults: 400 mg/time/day, drink for 3 days. May be increased to 5-7 days without adding unwanted effects.

Children: 5 mg/kg/day, drink for 3 days.

Giardia disease

400 mg/day/day, drink for 5 days.

Children and adults: 10 mg/kg/day, drink for 7 days.

Lymphatic worm disease (Wuchereria Bancrofti, Brugia Melafi), Potential thread (Eosin leukemia tropical lung disease)

diethylcarbamazin is a drug chosen to kill worms indicating larvae and adults. In areas where worms are only circulated, every year for a single dose of Albendazol 400 mg with diethylcabamazn 6 mg/kg or iVeMectin (200 micrograms/kg) has the effect of preventing the transmission disease. Such treatment continues for at least 5 years.

Toxocara infection (visceral larvae)

Adults or children: Same dose 400 mg/time x 2 times/day for 5 days.

Note: The above dose is for reference only. Specific dosage depends on the condition and level of progression of the disease. For a suitable dose, you need to consult a doctor or medical specialist.

What to do when using overdose?

What to do when you forget a dose? However, if close to the next dose, skip the forgotten dose and take the next dose at the time as planned. Note that it should not be used double the prescribed dose.

Side Effects

When using Albendazol 200 mg you may experience unwanted effects (ADR).

Common, ADR> 1/100

Systemic: Fever.

Central nerve: headache, dizziness, increased pressure in the brain.

Liver: Ordinary liver function.

Stomach - intestines: abdominal pain, nausea, vomiting.

Skin: Hair loss (recovery).

Uncommon, 1/1000

Systemic: Allergic reaction.

Blood: leukopenia.

Skin: skin, urticaria.

Kidney: Acute renal failure.

Rare, ADR

Blood: A decrease in granulocytes, reduced all bloody blood, granulocytes, platelets.

Instructions on how to handle ADR

When experiencing side effects of the drug, it is necessary to stop using and notify the doctor or go to the nearest medical facility for timely treatment.

Warnings

Before using the drug you need to read the instructions carefully and refer to the information below.

contraindicated

Albendazol 200 mg contraindicated in the following cases:

There is a history of hypersensitivity to benzimidazol compounds or some ingredients of the drug.

Pregnant women.

Be cautious when used

Before the treatment of tapeworm larvae in the nerve tissue, patients need to be carefully examined eye to eliminate retinal damage. It is necessary to be very careful when using any tapeworm larvae (albendazole), even after using corticosteroids can cause non -recovery damage when treating cysts in the eye or spinal cord.

Therefore, eye exams are needed to eliminate cysts in the retina before the treatment of nerve tapeworm larvae. Albendazole metabolizes strongly in the liver, so when cirrhosis, the speed of clearing drugs through the liver will decrease, thereby increasing the accumulation of drugs and increasing the unwanted effects of albendazol.

Therefore, be careful when using albendazol for people with liver dysfunction. It is necessary to carefully monitor liver function and count hemorrhoids 2 times in each treatment cycle, when treated with high and long -term doses in tapeworm larvae or Echinoccus tapeworm disease.

Eliminate pregnancy 1 month before starting high and long doses (by contraception without hormonal drugs during and after 1 month after taking the drug).

The ability to drive and operate machinery

no.

During pregnancy

Although it has not been studied in albendazols, it is not recommended for pregnant women due to animal tests that see the teratogenic ability of albendazol.

For women of childbearing age, albendazol should be used for the first 7 days of the menstrual cycle. When treated with albendazol, it is necessary to use the necessary contraceptive measures during and after 1 month.

The period of breastfeeding

is unknown how much the medicine is in the milk. Therefore, it is necessary to be very careful when using albendazol for nursing women.

Drug interaction

dexamethason: The concentration of substances with albendazol sulfoxid activity in plasma increases by about 50% when used in combination with dexamethasone.

Prazancelel: Praziquantel (40 mg/kg) increases the average concentration in plasma and area under the curve of Albendazol Sulfoxyd about 50% compared to using Albendazol alone (400 mg).

cimetidine: Albendazol sulfoxyd concentration in bile and in fluka cysts increased by about twice in people with cysts when used in combination with cimetidine (10 mg/kg/day) compared to using single albendazol (20 mg/kg/day).

Theophylin: The pharmacokinetics of theophylin does not change after taking 1 dose of Albendazol 400 mg.

Storage

In closed packaging, dry place, avoiding light. The temperature does not exceed 30 ° C.

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