Albutein intravenous infusion 25% grifols shock treatment for volume reduction (50ml)

Dosage form Box X 50ml
Specifications Albumin
Ingredient Alpha

Ingredient

Composition information	Content
Albumin	12.5g

Uses

indications

25% albutein drug is indicated in the following cases:

Treatment of volume shock.

is an auxiliary medicine in the hemorrhage for patients to be subject to long -term separation or patients overloaded and unable to tolerate a large amount of salt solution in the treatment of fever or lower blood pressure.

In surgery to connect the heart circulation of the heart, heart lung; However, the optimal treatment by infusion has not been established.

Cases of 25% albutein can be specified:

Acute respiratory failure syndrome (ARDS).

Severe injury or surgery causes an increase in albumin loss or incomplete synthesis.

Acute damaged kidneys responding to cyclophosphamide or steroid treatment. Steroid therapy can increase edema that can respond to the combination of albumin and diuretics.

Acute or ascites, the treatment is adjusted depending on the patient. Unless pathological condition causes reduction of blood albumin, albumin transmission only loses symptoms. There is no reasonable reason to use albumin as intravenous nutrients.

Used in children albumin 25% is indicated for blood transmission in medical treatment for hypernemenium bilirubin. The use of 25% albutein in children has not been clinically evaluated. Therefore, the doctor should consider the risk and benefits of the use of 25% albutein for children.

Pharmacology

albumin is a spherical protein, highly soluble (molecular weight 66,500), creating 70-80% of the glue pressure of plasma. Therefore, it is important in regulating the pressure of plasma. The 25% Albutein provides approximately 5 times the amount of glue with the same volume. It increases the volume of circulating plasma approximately 3.5 times the volume of fluid in 15 minutes, if the person is transmitted to be provided with adequate water, this additional fluid reduces blood concentration and blood viscosity. The level and time of increasing volume depending on the initial blood volume.

When treating patients with a decrease in blood volume, the albumin effect can exist for hours. Blood thinning lasts shorter when albumin is transmitted to patients with normal blood volume.

Albumin is also a natural shipping and cohesion protein with existing substances, drugs or toxins circulating in the circulation.

Albumin is distributed throughout the extracellular fluid and more than 60% of the albumin lake in the external area. The total number of albumin in the body of a 70 kg man is approximately 320 g, with a cycle of 15-20 days, synthesizing and regressing approximately 15 g/day.

Dynamic pharmacokinetics

Under normal conditions, the total amount of albumin can be exchanged is 4 - 5 g/kg body weight, of which 40 - 45% are present in the circuit and 55 - 60% inside the circuit. Increasing the permeability of capillaries will change albumin kinetics and abnormal distribution may occur in conditions such as severe burns or infections.

Under normal conditions, the average selling time for albumin is about 19 days. The balance between synthesis and decomposition is usually achieved by the feedback regulations. The elimination is mainly intracellular and by protease lysosome.

In healthy people, less than 10% of albumin is transmitted from the internal compartment in the first 2 hours after transmission. There is a significant change in individuals in affecting plasma volume. In some patients, plasma volume may still increase in several hours. However, in patients with serious illness, albumin may leak out of the vascular space at a significant amount at an unpredictable speed.

Before taking Albutein intravenous infusion 25% grifols shock treatment for volume reduction (50ml)

How to use

Use intravenous infusion.

Instructions for use

Remove the plastic lid on the top of the jar, peel off the rubber lid. Disinfect rubber lid with appropriate disinfection solution, not alcohol. Follow sterile techniques and prepare aseptic injection device as follows.

Close the lines lock.

Turn the bottle upside down, squeeze the drip chamber, poking the needle straight into the middle of the lid. No tilting or turning.

Immediately turn the bottle, relax the drip chamber to automatically create the appropriate fluid in the drip chamber (half full).

Install the needle in the line, unlock and chase the air out of the needle and the line, then close the lock.

Intravenous and drop adjustment.

Remove all the infusion tool after use. Remove all excess medicine.

When the infusion kit is not used.

Remove the plastic lid on the top of the jar, peel off the rubber lid. Disinfect rubber lid with appropriate disinfection solution, not alcohol. Follow aseptic technique and prepare aseptic injection device as follows:

Use aseptic technique, install filter needles in a single -time sterile plastic syringe.

Pipe the filter needle into the 25%albutein solution.

Draw a 25% albutein solution from the bottle to the syringe.

withdraw and throw the needle from the syringe.

Install the desired size needle in the syringe.

Remove all the infusion tool after use. Remove all excess medicine.

Dosage

Total dose changes for individuals.

In adults, the first infusion dose is 100 ml proposed. Additional dose depends on clinical indications. When treating patients with shock with a great decrease in blood, 25% albutein can be transmitted faster if necessary to improve clinical condition and restore blood volume. This dose can be repeated for 15 - 30 minutes if the first dose is not enough.

In patients with normal blood volume or slight decrease, normal transmission speed or slight decrease, the communication speed is usually 1 ml/min.

If the 25% albutein dilution is clinically required, the compatible dilution solution includes 0.9% sterile sodium chloride solution or 5% sterile dextrose in water.

Use in children: Using 25% albutein in children, not clinically evaluated. The dosage varies depending on the clinical and weight condition. Typically, the dose ¼ to ½ of the large dose can be infected, or the dose can be calculated on the basis of 0.6 to 1 g/kg weight (2.4 to 4 ml of 25%albutein). For children with jaundice due to neonatal hemolysis, the appropriate dose to reduce free serum bilirubin is 1 g/kg of weight during the process. Transmission speed in children is ¼ of adult speed.

Injecting products should be tested by eye to detect sediment and discoloration before use, whenever the solution and bottle allow.

Note: The above dose is for reference only. Specific dosage depends on the condition and level of progression of the disease. For a suitable dose, you need to consult a doctor or medical specialist.What to do when overdose?

Overdose

Hyperbonemia may occur if the dosage and transmission speed are too high. When the first clinical sign of cardiovascular overload (headache, shortness of breath, intravenous obstruction), or hypertension, increased central vein pressure and pulmonary edema.

How to handle

Should stop transmission immediately and carefully monitor the patient's hemodynamic parameters.

What to do when you forget 1 dose?

There is no information.

Side Effects

When using 25%albutein, you may experience unwanted effects (ADR).

The most common side effects include fever and chills; Rashes, nausea, vomiting, fast heartbeat and hypotension have also been reported. If the reaction occurs slowly and stop transmitting in a short time may cause loss of symptoms. If the transmission is stopped and the patient requires 25% albutein transmission should use the product of another batch.

Albutein 25% especially if transmitted quickly, can cause overload leading to pulmonary edema.

Warnings

Before using the drug you need to read the instructions carefully and refer to the information below.

Contraindicated

Albutein drug 25% contraindicated in the following cases:

Patients with severe anemia or heart failure with normal or increased intravascular blood volume.

Patients with a history of allergic reactions to this product.

Caution when using

after the reports that there is a risk of existence of the potential dark blood and acute kidney failure due to the improper use of aseptic phase water as a substance using albumin dilution (Human), if the dilution is required, the acceptable diluted solution is the 0.9% sodium chloride or 5% in the water.

Albutein 25% is produced from human plasma lakes. Based on the purification of people with effective plasma and product production processes, it has an extremely distant risk of virus transmission, including the theory of Creutzfeldt - Jakob (CJD) theory. Although there is no viral or CJD transmission case that is recognized by albumin, the risk of infectious agents cannot be excluded. Doctors should consider the risks and benefits of using this product and should discuss this to the patient.

25% albutein solution should not be used if you see chisel, sediment in vials. Do not use after opening more than 4 hours. Throw away the unused part.

Albutein 25% should be carefully transmitted in patients with low heart reserves.

Quick transmission can be overloaded leading to pulmonary edema. Patients should be closely monitored by signs of increased venous pressure.

Rhearse blood pressure after compulsory monitoring carefully for patients with trauma or postoperative surgery to detect and treat serious blood vessel disease without bleeding at lower pressure.

Patients with significant dehydration require additional infusion, 25% albutein can be transmitted with normal dextrose and salin intravenous fluids. However, which solution contains hydrolyzed or alcoholic proteins not combined with a line of lines with 25% albutein because it can cause protein precipitate.

The ability to drive and operate machinery

does not affect.

Pregnancy

Albutein 25% belongs to c.

Studies on the reproduction of animals have not been conducted with 25%albutein. It is also unclear whether albutein is whether or not damage the fetus when used for pregnant women or affect fertility. 25% Albutein is only for pregnant women when really necessary.

The period of breastfeeding

There is no study on the use of 25% albutein on humans as well as animals in the breastfeeding period. Only use when really necessary.

Drug interaction

Prkallikrein in some preparations that can stimulate the change of kininogen in human blood into kinin causing hypotension. Albumin -contaminated albumin solution can be toxic to those who have been transmitted a large amount of albumin, leading to bone and brain diseases.

Storage

Albutein 25% stabilizes in 3 years if stored at a temperature not exceeding 30 ° C. Do not stop the ice.

When opened only within 4 hours and throw away the rest.

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