Aldan Tablets 5mg Polfarmex treatment for hypertension (3 blisters x 10 tablets)

Amlodipine has anti -hypertension effects by directly relaxing smooth muscles around the peripheral artery and has less effect on myocardial calcium channel. Therefore, the drug does not conduct the atrial - ventricular in the heart and does not adversely affect the muscle tone.

Amlodipine also works well, which reduces the impact of kidney blood vessels, thus increasing blood flow in the kidneys and improving kidney function.

Dynamic pharmacokinetics

Birth of amlodipine when drinking about 60 - 80% and not affected by food. The peak concentration of plasma is achieved after taking the recommended dose for 6-12 hours. Selling time for plasma is from 30 - 40 hours. Stable concentration in plasma reaches 7-8 days after taking the drug once a day. The drug is mainly metabolized through the liver.

Caution when using

increased angina, myocardial infarction

Especially in people with serious coronary artery disease. It is possible to increase the frequency, time, severity of spasms or acute myocardial infarction when starting to use calcium inhibitors or at times of dosage increase. However, this case is rare.

Caution: Because Amlodipine vasodilation is sequentially at the beginning of use, it rarely causes hypotension when taking amlodipine. However, it is necessary to be cautious when taking this drug as the same as when using other peripheral vasodilators, especially for serious aortic stenosis patients.

In patients with congestive heart failure

Studies on hemodynamics and control tests of NYHA with group II - III heart failure shows that Amlodipine does not seriously cause clinical heart failure after measurement of tolerance through exercise, blood emulsion rate of left ventricle (EF) and clinical symptoms. However, studies have not mentioned patients with NYHA's heart failure IV. In general, all calcium inhibitors need to be used carefully in heart failure patients.

Amlodipine is reported related to an increase in pulmonary edema in patients with non -heart failure due to anemia at level III - IV according to NYHA. However, there is no significant difference in the proportion of patients with severe heart failure compared to placebo.

Stop using β blockers

Amlodipine is not a β blocker and therefore, does not resist the risk of sudden stop use of β blockers. Therefore, whenever the drug is stopped, it must be slowly reduced by the dosage of β blockers.

Patients with liver failure

As well as all calcium antagonists, amlodipine's semi -canceling time is prolonged in patients with liver failure and has not been determined to do the recommended dose. Should take medicine carefully in these patients.

Patients with renal failure

Amlodipine is widely metabolized into non -active substances with 10% eliminated in a constant form in urine. Amlodipine plasma changes are not related to the level of renal failure. Amlodipine can be used for these patients in normal doses. Amlodipine cannot be appraised.

Elderly

Time reaches the maximum concentration in Amlodipine's plasma in the elderly is the same as young people. Amlodipine clearance tends to decrease, resulting in an increase in AUC and the semi -disposal time in the elderly. The increase in AUC and the sale time in patients with congestive heart failure is also suitable for forecasts in patients in the research group.

Amlodipine is used in the same dose for the elderly and young people due to the same good tolerance. Therefore, the usual dosage can also be used for the elderly.

Children

Not yet determined the effectiveness and safety of Amlodipine in children.

The ability to drive and operate machinery

If the patient uses this drug, be careful when driving or operating machinery. Amlodipine does not directly affect the ability to drive or operate machinery. However, some patients have dizzy side effects or drowsy due to lower blood pressure.

These unwanted effects often occur when starting to use amlodipine or after increasing the dose. If you know these unwanted effects, advise patients not to drive or avoid other activities that need alertness.

Pregnancy

Classification of pregnancy by FDA.

Calcium channel blockers can inhibit early uterine contractions. However, the drug has no adverse effects on the birth process. The risk of oxygen deficiency must be taken into account if causing hypotension in the mother, because there is a risk of reducing placental perfusion. This is a common risk when using hypertension medications, they can change the blood flow due to peripheral vasodilation.

In Vivo, a calcium channel blocker can cause teratogenic bone deformities. Therefore, avoid using amlodipine for pregnant women, especially in the first 3 months of pregnancy.

Breastfeeding period

There is no data to evaluate the accumulation of Amlodipin in breast milk.

Interactive drug

Notice to the doctor that the drugs are taking or have recently used, including non -prescribing drugs. Some drugs (including non -prescribed drugs, medicinal herbs or natural products) may interact with amlodipine.

Patients must notify the doctor if taking any of the following drugs:

Medicines reduce blood pressure (β blockers, ACE inhibitors, α1 blockers and diuretics). Amlodipine may increase the hypotension effect of these drugs.

Incaried with cardiovascular drugs (diltiazem), antifungal drugs (ketoconazole, otraconazole), HIV Protease inhibitors (antiviral drugs used for HIV treatment), depression treatment (nefazodon) can increase the effects of amlodipine.

Incaried with antibiotics (rifampicin, rifabutin), herbal medicine to treat depression, dexamethasone, anti -convulsions (phenobarbital, phenytoin, carbamazepine), antiviral drugs (nevirapin) can reduce the effect of amlodipine.

Anesthesia increases the anti -hypertension effect of amlodipine and can make blood pressure more sharply.

Non -steroid anti -inflammatory drugs, especially indomethacin, can reduce the anti -hypertension effect of amlodipine due to the synthesis of prostaglandin and/or hold sodium and fluid.