Aldoric Fort 200mg S.P.M is treated with osteoarthritis, arthritis (3 blisters x 10 tablets)

Dosage form Box of 3 blisters x 10 tablets
Specifications Celecoxibum
Ingredient The company tried to S.P.M part

Ingredient

Composition information	Content
Celecoxibum	200mg

Uses

indications

Aldoric Fort drug indicated in the following cases:

Treatment of symptoms of osteoarthritis in adults. Reduce the number of family gland polyps in the colon. Pain, fever. The mechanism of action of Celecoxib is considered to inhibit prostaglandin synthesis, mainly through the inhibition of isenzyme cyclooxygenase-2 (COX-2), resulting in a reduction in the formation of prostaglandin. Unlike the majority of previous nonsteroidal anti-inflammatory drugs, Celecoxib does not inhibit isenzyme cyclooxygenase-1 (COX-1) with human treatment concentrations. Cox-1 is a structural enzyme found in almost all tissues, large and platelet leukocytes. Cox-1 participates in thrombosis (such as thrombocytopenia to stop training) to maintain the protective mucosa fence of the stomach and kidney function (such as maintaining kidney perfusion). Due to the non-inhibition of COX-1, Celecoxib is less likely to cause unwanted effects (for example, platelets, stomach mucosa), but can cause unwanted effects in the kidneys similar to non-selective non-steroid anti-inflammatory drugs.

Dynamic pharmacokinetics

Absorption: After taking about 3 hours, will reach the peak content of Celecoxib in plasma. With a dose of 100 - 200 mg used in clinically, the peak content in plasma and the area under the curve (AUC) of Celecoxib is proportional to the dose.

Distribution: In healthy people, Celecoxib is strongly attached to protein - plasma when used for treatment.

Metabolism: Celecoxib metabolism mainly via cytochrom P450 2C9 in the liver. Found in people with 3 metabolites: The first alcohol, the corresponding carboxylic acid and glucuro - complex, these metabolites are all inhibited inhibitors, or COX2.

Elimination: Celecoxib excreted mainly through metabolism in the liver. In feces and urine there are very few mother quality.

Before taking Aldoric Fort 200mg S.P.M is treated with osteoarthritis, arthritis (3 blisters x 10 tablets)

How to use

oral medication 01 times or divided into 2 times equally, all have the same effect in the treatment of bone - joint degeneration. For rheumatoid arthritis, the dose should be divided equally into 2 times. The dose is up to 200mg/time, drink 2 times a day, can drink without paying attention to the meal; Higher doses (ie 400mg/time, 2 times a day) must be taken at meals (with food) to improve absorption.

Dosage

Bone degeneration - joints: To treat bone - joint degeneration, the dose must be adjusted according to the needs and response of each patient, finding the lowest dose effectively. The usual dose of 200mg/day orally or divided into 2 equal doses. The dose is higher than 200mg/day (such as 200mg/1 dose, 2 times a day) is not more effective.

Rheumatoid arthritis in adults: Normal doses of 100 - 200mg/time, taken 2 times a day, higher doses (400mg/1 time, 2 times a day) does not work better.

POLY POLLY IN THE GRADE: DOSIS 400mg/Time, Take 2 times a day.

Pain in general and menstruation: Usually in adults: 400mg oral 1 time, followed by 200mg if necessary, on the first day. To continue analgesic, can give 200mg of oral dose twice a day, if necessary.

Elderly (over 65 years): No dose adjustment, although the drug concentration in plasma increases. However, for the elderly with a body weight of less than 50 kg, the lowest recommended dose must be used at the beginning of treatment.

Children: Not yet studied and not recommended for children.

Renal failure: Unsurprised and not recommended for people with severe kidney failure. If it is necessary to use Celecoxib for people with renal failure, careful supervision. kidney function.

Hepatic failure: Not yet studied. Do not be used for people with severe liver failure. For moderate liver failure, recommendations should be reduced by 50%.

Note: The above dose is for reference only. Specific dosage depends on the condition and level of progression of the disease. For a suitable dose, you need to consult a doctor or medical specialist.What do

do when using overdose? The gastrointestinal bleeding may be encountered.

If NSAID overdose, symptomatic treatment and support treatment. There is no specific antidote.

If the poisoning is new within 4 hours and there are overdose symptoms, which can be indicated to cause vomiting and/or drinking activated carbon and/or oral bleaching.

Notice immediately to the doctor the unwanted effects when using the drug overdose.

What to do when you forget 1 dose? However, if the time to relax with the next dose is too short, skip the dose and continue the calendar of the drug. Do not use double dose to compensate for missed dose.

Side Effects

When using Aldoric Fort, unwanted effects (ADR) such as:

The unwanted effect of Celecoxib at the common dose is generally light and is mainly related to the digestive tract.

Digestive: abdominal pain, diarrhea, indigestion, flatulence, nausea. Rare intestinal obstruction, intestinal perforation, gastrointestinal bleeding. Peeling dermatitis, Stevens-Johnson syndrome.

Warnings

Before using the drug you need to read the instructions carefully and refer to the information below.

contraindicated

Aldoric Fort is contraindicated in the following cases:

Not used in people who are hypersensitively to caught any ingredients of the drug, with sulphonamid. Severe heart failure; severe liver failure; Severe renal failure (Creatinine clearance ratio

Be cautious when using

do not use Celecoxib to replace corticosteroids or to treat corticosteroids. Sudden corticosteroid stops can cause a drama that responds to corticosteroids.

Gastrointestinal tract: Sometimes the risk of ulcers, bleeding and puncture of the gastrointestinal tract, serious toxicity of the gastrointestinal tract such as bleeding, ulcers and perforation of the stomach, small intestine and large intestine.

Be careful to use Celecoxib for the elderly, weakened because it is easy to cause gastrointestinal bleeding and often the renal function is impaired due to age.

Celecoxib can be toxic to the kidneys, especially when maintaining the blood flow through the kidneys, it requires the support of the kidney prostaglandin. People with high risk include people with kidney failure, heart failure or liver failure. It is necessary to be very careful to use Celecoxib for these patients.

The effect of drugs on driving and operating machinery

does not affect the ability to drive and operate machinery.

Using drugs for women during pregnancy and lactation

There are no complete studies on Celecoxib in pregnant women. Celecoxib should only be used for pregnant women when the benefits are higher than the risk that may occur for the fetus. Do not take the drug in the last 3 months of pregnancy, as Prostaglandin synthesis inhibitors may have a bad effect on the cardiovascular system of the fetus.

Celecoxib excreted through Cai mouse milk with equivalent concentration in plasma. It is not clear whether Celecoxib whether or not breast milk. Because there are many drugs through breast milk and because of the serious reaction of celecoxib breastfeeding, it is necessary to decide or the mother stops the drug or stops breastfeeding, taking into account the importance of Celecoxib to treat the mother.

Drug interaction

General interaction: Celecoxib specializes in cytochrom P450 2C9 in the liver; Therefore, it is necessary to be careful when coordinating Celecoxib with P450 2C9 inhibitors.

Angiotensin (ACE): NSAIDs reduces the anti -hypertension effect of ACE inhibitors.

Furosemid: In some patients, NSAIDs have a reduced effect on na+/urinary effects of Furosemid.

Aspirin: ASPIRIN combination with Celecoxib may increase the speed of gastrointestinal ulcers or other complications.

fluconazole: in combination with Fluconazole 200 mg doubles plasma Celecoxib levels.

Storage

Leave a cool place, avoid light, temperatures below 30⁰C.

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