Alenta 70mg Getz medicine for osteoporosis (1 blister x 4 tablets)

Dosage form Box of 1 blister x 4 tablets
Specifications Alendronic Acid
Ingredient Osteoporosis, osteoporosis in South, Paget bone

Ingredient

Composition information	Content
Alendronic Acid	70mg

Uses

indications

Alenta 70mg drug is indicated in the following cases:

Treat osteoporosis in postmenopausal women. Alendronic acid reduces the risk of spinal and hip fractures. Reducing the incidence of the spine, but not the broken vertebra of the living body has been proven. Date).

Pharmacokic

Sodium Alendronate is a bisphosphonate that is similar to pyrophosphate associated with hydroxyapatite in the bone.

The drug has a strong inhibition effect and localized to the absorption position of the bone, especially right below the cell canvel. The cell canceling the bone surface of the bone but often lacks the rugged sticky rice that indicates the cancellation activity.

Alendronate does not interfere with the attraction or adhesion of the cell canvel but it inhibits the activity of the cell cancel. When entering the bone block, Alendronate has no pharmacological effect. Therefore, Alendronate should be continuously used to inhibit the cancellation of the cells at the newly formed surfaces.

Pharmacokinetics

absorption

The drug is absorbed in a small amount after taken. Absorption decreased by food, especially foods that contain calcium or other valence ions. Born is about 0.4% when taking the drug again before eating, decreasing from 0.7% at fast meals, absorbing negligible when taking the drug 2 hours after meals.

Distribution

The volume of distribution in a stable state, including the bone with least 28L. Drugs connected about 78% of plasma proteins.

Metabolism

There is no evidence that alendronate (alendronic acid) is metabolized in animals or humans.

Elimination

About half of the absorption is excreted through urine. The rest is accumulated in the bone. The sale time of the drug is estimated at 10 years.

Before taking Alenta 70mg Getz medicine for osteoporosis (1 blister x 4 tablets)

How to use

Take oral use.

Patients should drink when hungry when waking up in the morning, drink with water (not less than 200ml), at least 30 minutes before eating, taking or taking other drugs during the day.

Should be supplemented with calcium and vitamin D if the diet is incomplete.

The pill should not chew, suck or dissolve in the mouth because of the risk of mouth ulcers.

Patients should not lie down until the first meal of the day, at least 30 minutes after taking the drug.

Do not lie down for 30 minutes after taking the medication.

Dosage

Optimized bisphosphonate treatment for osteoporosis has not been set. The need to continue treatment should be periodically assessed based on the benefits and potential risks in each patient, especially after use for 5 years or more.

Treatment of postmenopausal osteoporosis: Dosage recommended every 10mg once a day.

Treatment of osteoporosis in men: The recommended dose is 10mg once a day.

The oral dose depends on the age and condition of each object, recommended 70mg per week.

No need to adjust the dose for older patients.

No dose adjustment in patients with glomerular filtration GFR> 35 ml/min.

Use for patients with liver failure: No dose adjustment.

Children under 18 years of age are not recommended to use Alenta 70mg.

Note: The above dose is for reference only. Specific dosage depends on the condition and level of progression of the disease. For a suitable dose, you need to consult a doctor or medical specialist.What to do when overdose?

Needed for patients to drink milk or antacids to combine alendronate. Due to the risk of esophageal irritation, do not cause vomiting and patients need to be completely vertical.

What to do when you forget 1 dose? Patients should not use 2 capsules on the same day but should return to use 1 tablet/week as the original plan on the selected day.

Side Effects

When using Alenta 70mg, you may experience unwanted effects (ADR).

Common, ADR> 1/100

Nervous system: headache, dizziness, dizziness.

Digestive system: abdominal pain, indigestion, constipation, diarrhea, flatulence, esophageal ulcer, difficulty swallowing, bloating, heartburn.

Skin and subcutaneous tissue: Hair loss, itching.

Osteoarthritis, connective tissue and bone: musculoskeletal pain (bone, muscle or joint) is sometimes very serious.

Other: weakness, peripheral edema.

Uncommon, 1/1000

Nervous system: taste disorders.

Eyes: Eye infections (grape veins, concentration or inflammation on the contents).

Digestive system: Nausea, vomiting, gastritis, esophagitis, esophageal erosion, black stools.

Skin and subcutaneous tissue: rash, erythema.

Other: Symptoms such as acute reactions (muscle pain, weakness and rare fever), when starting treatment.

Instructions on how to handle ADR

When having minor adverse adverse reactions, it is necessary to stop using. In case of heavy sensitivity, it is necessary to notify the doctor and quickly go to the nearest medical facility for timely handling.

Warnings

Before using the drug you need to read the instructions carefully and refer to the information below.

contraindicated

Alenta 70mg contraindications in the following cases:

Hypersensitivity to any ingredients of the drug.

Caution when using

Caution

It is necessary to consider the causes of osteoporosis other than the causes of estrogen deficiency, age and use of glucocorticoid.

Adjust the condition of hypocalcaemia before starting treatment with sodium alendronate.

Other disorders that affect mineral metabolism (such as vitamin D deficiency) should also be treated. Need to monitor blood calcium concentration and symptoms of lowering calcium in these patients, ensuring adequate amount of calcium collected and the amount of vitamin D melon into the body is especially important for patients with bone paget disease and patients who are using glucocorticoids because of the mitigation of calcium and server phosphate without the accompanying symptoms that can occur when treated with sodium alendronat.

Precautions on the digestive system

Patients should stop treating if the symptoms may occur reaction in the esophagus including combination disorders, swallowing pain, pain behind the breastbone, new heartburn or worsening.

Be cautious when using drugs for patients with progressive digestive disorders.

local jaw bone necrosis (ONJ)

The condition is often associated with tooth extraction and/or local infections (including bone inflammation) recorded in patients who dilute the workshop using alendronate.

Risk factors can develop local jaw bone necrosis:

Effect of bisphosphonate (the highest is zoledronic acid), sugar and accumulated dose.

Patients with cancer, chemotherapy, radiation, corticosteroid, smoking.

There is a history of dental disease, poor oral hygiene, periodontal disease, invasive dental procedure and poor quality dentures.

It is necessary to consider dental examination to take appropriate preventive measures before starting treatment with oral bisphosphonate in patients with bad teeth. During treatment, all patients need to be encouraged to maintain good oral hygiene, regular dental examination.

muscle, bone and joint pain

Symptoms of muscle pain, bones and joints are rarely serious, which loses the ability to exercise. At the beginning of a day to appear from 1 day to several months after the beginning of treatment. Patients will mitigate symptoms after stopping the drug.

Bades on the thigh bone are not typical

Most occurs in patients treating prolonged osteoporosis. During treatment, patients should report any symptoms of thigh pain, hips or cave pain for the condition.

Skin reaction

Rarely appear serious skin reactions such as Stevens Johnson syndrome and epidermal necrosis due to poisoning.

Do not use sodium alendronate for patients with severe coal failure (GFR

Chemical trip

Monitor blood calcium levels and symptoms of calcium lower during the use of the drug. It is necessary to ensure adequate supply of calcium and vitamin D is especially important in patients using glucocorticoids.

Glucocorticoid osteoporosis

Patients need to evaluate the density of minerals in the bone before using sodium alendronate combination therapy with glucocorticoid and repeat after 6 - 12 months.

Alenta contains lactose so patients have rare genetic problems galactose, lactase deficiency or glucose-galactose should not use this drug.

The ability to drive and operate machinery

There is no study conducted on the effect of drugs on driving and operating machinery. However, unwanted effects know when using the drug can affect some patients.

Pregnancy

should only use sodium alendronate during pregnancy if the benefits of treatment are higher than the risk of the mother and the fetus.

The period of breastfeeding

It is unknown whether sodium alendronate is excreted in breast milk or not. Therefore, it is necessary to be cautious when used for breastfeeding women.

Drug interaction

estrogen : Increases bone mass and reduces more bone metabolism. gut.

Storage

Store in a dry place, avoid light and humidity, temperature below 30 ºC.

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