Alfokid Syrup Kolmar medicine for reducing cough caused by chronic bronchitis, respiratory infections (20 bags)

Dosage form Syrup
Specifications Box of 20 bags
Ingredient The ivy leaf extract

Ingredient

Thành phần cho 5ml

Composition information	Content
The ivy leaf extract	0.1g

Uses

Indications

syrup alfokid helps improve symptoms of chronic bronchitis, reduces cough due to acute inflammation of respiratory organs.

Pharmacokic

The saponins in the ivy leaf extract (hederacosid C, α-hederin) have anti-spasms and stimulate sputum secretion. According to recent research results, the mechanism of impact of saponins is due to the indirect impact of α-hederin on β2-adrenergic. In theory, these substances inhibit the import of β2 receptor in the lungs. Therefore, the β2 receptor is retained in the lipid patches of the cell membrane and continues to be activated by adrenalin. Countless reaction reactions include the production of surfactants in lung epithelium. Especially, the surface activity of protein B (SP-B) reduces surface tension, whereby mucus is reduced and they are convenient. The anti-spasm effect of saponin is due to increased reception of β2-adrenergic, leading to bronchial smooth muscle relaxation.

Dynamic pharmacokinetics

Can not find hederacosid c in the blood caused by hederacosid C has transformed into α-hederin in the stomach. The pharmacokinetics of α-hederin for the only dose have been tested on the Wistar male mouse. Triti radio isotope is used as a marked radioactive material. α-Hederin has its own radioactivity of 1,398 µci/mg. The results of the study showed the absorption in the blood and continued to enter the liver and lungs. A main study was conducted over 336 hours. 335 mg/kg α-hederin (corresponding to a dose for a person is 23.4mg in a patient 70 kg) is used in the only dose for the Wistar male mouse.

From the main studies displayed, the maximum level of radiation in the blood can be discovered at 24 hours (TMAX). At 24 hours, the highest concentration of about 5% of the total number of radioactive is detected in the blood. The total body absorption at 24 hours is estimated to have at least 30% of the total radioactive amount. Absorb and eliminate α-Hederin is completed in 336 hours. The radiation of 1 g of lung tissue is recorded 5.55 + 05 dpm (α-hederin group) and 5.76 + 05 dpm (in α-hederin + ivy extract).

The radioactive at 24 hours of the lungs is recorded as 0.02 µci/g of tissue (in the α-hederin group) and 0.025 µci/g of tissue (in α-hederin + ivy extract). α-Hederin has its own radioactive 1,398 µci/mg.

Before taking Alfokid Syrup Kolmar medicine for reducing cough caused by chronic bronchitis, respiratory infections (20 bags)

How to use

Syrup Alfokid uses oral.

Dosage

recommended dose:

Age ≥ 15 years: 1 bag (5 ml)/time, 3 times/day. Specific dosage depends on the condition and level of progression of the disease. For a suitable dose, you need to consult a doctor or medical specialist.What to do when using overdose?

What to do when you forget 1 dose? However, if the time to relax with the next dose is too short, skip the dose and continue the calendar of the drug. Do not use double dose to compensate for missed dose.

Side Effects

The frequency of abnormal symptoms is divided into: rarely ≥ 0.01%and

The appearance of the following symptoms:

The digestive system: rarely diarrhea, vomiting or nausea. (PMS) performed in 651 patients in 6 years in Korea on the re -evaluation of the drug, the appearance of abnormal symptoms is 0.46% (3 cases/651 cases), 2 cases of abdominal pain, 1 case of obstacles, nausea, vomiting, nausea have been reported.

From the market monitoring (PMS) performed in 9657 patients abroad, combined with ivy leaves and antibiotics/chemotherapy, the frequency of abnormal symptoms is 26% and when combining antibiotic drugs, frequency of abnormal symptoms increases more when only use only ivy, it is reported that the frequency of abnormal symptoms has increased relatively. According to PMS report, abnormal symptoms are for mild and temporary digestive systems. Abnormal symptoms, 46 patients have stopped in doses and symptoms are usually in the digestive system (18 patients with diarrhea).

Do not improve the symptoms after use for a week.

Instructions on how to handle ADR:

Notify the physician the unwanted effects when using the drug.

Warnings

Before using the drug you need to read the instructions carefully and refer to the information below.

Contraindicated

Alfokid Syrup is contraindicated in the following cases:

Patients with a history of hypersensitivity to the ingredients of the drug. Minh).

Be cautious when using

Patients listed below should consult a doctor or pharmacist before use:

Patients with gastritis or stomach ulcers. Road.

The effect of the drug on driving and operating machinery

does not affect the ability to drive and operate machinery.

Use drugs for women during pregnancy and lactation

Not for pregnant and lactating women.

Drug interaction

so far, no drug interaction has been reported.

Storage

Leave a cool place, avoid light, temperature below 30⁰C.

Other drugs

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