Allerphast 180mg Mebiphar medicine for seasonal allergic rhinitis, indefinite urticaria (1 blister x 10 tablets)

Dosage form Film bag tablets
Specifications Box of 1 blister x 10 tablets
Ingredient Fexofenadin hydrochlorid

Ingredient

Composition information	Content
Fexofenadin hydrochlorid	180mg

Uses

Indications

allerphast is indicated in case:

Treatment of symptoms in seasonal allergic rhinitis, malefinity chronic urticaria in adults and children over 6 years old.

The drug is a metabolic substance of terfenadin, also competing with histamine at H1 receptors in the digestive tract, blood vessels and respiratory tract, but no toxicity for the heart due to not inhibiting potassium channels associated with myocardial cycle.

Fexofenadin has no significant effect on acetylcholin antagonism, dopamine antagonism and has no effect on receptor inhibiting Alpha1 or Beta - Adrenergic.

In the treatment dose, the drug does not cause sleep or affects the central nervous system. The drug has a fast and prolonged effect due to slow -attached drugs into H1 receptors, forming a sustainable complex and slowly separated.

Pharmacokinetics

absorption

Good absorption drug when taken oral and start to work after drinking 60 minutes. The peak concentration in the blood is achieved after 2-3 hours. Fat -rich foods reduce the peak concentration in plasma by about 17% and extend the time to reach the peak concentration of the drug (until about 4 hours). Anti -antihistamine effect lasts more than 12 hours.

Distribution

The ratio of the plasma protein of the drug is 60 - 70%, mainly with albumin and alpha1 - Glycoprotein acid. It is unclear whether the drug will be through the placenta or excreted into breast milk. Fexofenadin does not pass the blood - brain barrier.

Metabolism

Fexofenadin is very little metabolized.

Elimination

FEXOFENADIN SELLING Time is about 14.4 hours, longer (31 - 72%) in kidney failure people. The drug excreted mainly in feces (approximately 80%) and urine (11 - 12%) in constant form.

Before taking Allerphast 180mg Mebiphar medicine for seasonal allergic rhinitis, indefinite urticaria (1 blister x 10 tablets)

How to use

oral medication.

Dosage

Allergic rhinitis

Adults and children over 12 years: take 1 tablet (180 mg) x 1 time/day. Increase the dose to 2 capsules 2 times/day, but do not increase the effect of treatment.

Children from 6 - 12 years: 30 mg x 2 times/day, should be used with lower content to match this dose.

Standing chronic urticaria

Adults and children over 12 years: take 1 tablet (180 mg) x 1 time/day.

Children from 6 - 12 years old: 30 mg x 2 times/day, should be used in the form of a lower content to match this dose.

People with kidney failure

Adults and children over 12 years of age with kidney failure or hemolysis: 1/2 tablet (60 mg) x 1 time/day.

Children from 6 - 12 years old with renal failure: 30 mg x 1 time/day, should use a lower -prone form to fit this dose.

Hepatic impairments

No dose adjustment.

Note: The above dose is for reference only. Specific dosage depends on the condition and level of progression of the disease. For a suitable dose, you need to consult a doctor or medical specialist.

What to do when overdose? However, drowsiness, dizziness, dry mouth have been reported.

Handling: Using conventional measures to remove the drug that has not been absorbed in the digestive tract. Support support and symptomatic treatment. Hemolysis is negligible in blood concentration (1.7%). There is no specific antidote.

In an emergency, call the 115 emergency center immediately or go to the nearest local health station.

What to do when you forget a dose? However, if close to the next dose, skip the forgotten dose and take the next dose at the time as planned. Do not use double the prescribed dose.

Side Effects

When using Allerphast 180 mg often has unwanted effects (ADR).

Common, ADR> 1/100

Neurological: Drowsy, tired, headache, insomnia, dizziness.

digestive: nausea, indigestion.

Uncommon, 1/1000

Neurological: Fear, sleep disorders, nightmares; Dry mouth.

digestive: abdominal pain.

Rare, ADR

Skin: skin, urticaria, itching.

Systemic body: Fengbo, chest tightness, shortness of breath, redness, anaphylaxis.

Instructions on how to handle ADR

When experiencing side effects of the drug, it is necessary to stop using and notify the doctor or go to the nearest medical facility for timely treatment.

Warnings

contraindicated

Allerphast is contraindicated in the following cases:

Hypersensitivity to fexofenadin or other ingredients of the drug.

Be cautious when using

Although there is no toxicity on the heart like Terfenadin, but still be cautious when taking drugs for people who are at risk of cardiovascular or have a long -lasting QT range.

Caution and use of appropriate doses for patients with impaired renal function due to increased plasma drug concentration due to prolonged sale time.

Patients should not use other antihistamine drugs while using fexofenadin.

Safety and effectiveness of drugs for children under 6 years old have not been determined.

It is necessary to stop using fexofenadin at least 24 - 48 hours before conducting skin injection tests.

The ability to drive and operate machinery

The drug is less likely to affect the ability to drive and operate machinery. However, it is necessary to check the personal reaction before driving or perform complex tasks to detect people who are sensitive to the drug.

Pregnancy

There is no full research on pregnant people, so only use fexofenadin for pregnant women when the maternal benefits are superior to the risk for the fetus.

The period of breastfeeding

has not clearly defined whether the drug is excreted through breast milk or not, so it is necessary to be cautious when taking the drug for breastfeeding women.

Drug interaction

erythromycin and ketoconazole increases the concentration and time of fexofenadin in the blood, but this interaction has no clinical significance.

Antacuric antacids containing aluminum and magnesi if used simultaneously with fexofenadin will reduce the absorption of the drug, so they must use these drugs about 2 hours apart.

Storage

Avoid light and moist, temperatures below 30 ° C.

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