Alphagan P Allergan eye drops for glaucoma (5ml)

Dosage form Bottle x 5ml
Specifications Brimonidin tartrat
Ingredient Gleloms are closed, glaucoma, glaucoma, glaucoma

Ingredient

Thành phần cho 5ml

Composition information	Content
Brimonidin tartrat	7.5mg

Uses

indications

Alphagan drugs are indicated in the following cases:

Pressure hypertrophy or lower glaucoma in patients with open angle glaucoma.

Pharmacokic

Alphagan is the agent at Alpha Adrenergic receptor. Two hours after the eye, the drug is achieved maximum opaque effect. Researched with fluorescent measurements on animals and on humans shows that Brimonidin Tartrat has a double mechanism of effect: both reducing the secretion of aquaculture, and increasing the drainage in the canal - Ivani.

Dynamic pharmacokinetics

After a small amount of 0.1% or 0.2% solution into the eyes, will reach the peak concentration of plasma within 0.5 - 2.5 hours and decrease, the half -body sale time is about 2 hours. In humans, brimonidin metabolizes the whole body, mainly in the liver. Eliminate the main urine, in the form of initial drugs and metabolites. About 87% of the oral dosage of Brimonidin marked was discharged for 120 hours, of which 74% found in the urine.

Before taking Alphagan P Allergan eye drops for glaucoma (5ml)

How to use

Alphagan is used in small eyes.

Dosage

recommended dose is a drop of Alphagan (Brimonidin Tartrat eye solution 0.15% small into the eye 3 times a day, 8 hours apart). If more than one eye drops, the drugs must be spaced at least 5 minutes apart.

Note: The above dose is for reference only. Specific dosage depends on the condition and level of progression of the disease. For a suitable dose, you need to consult a doctor or medical specialist.

What to do when overdose?

Overdose of the whole body due to accidentally swallowing: There is very little information related to accidentally swallowing in adults. The only side effect reported is hypotension. Oral overdose treatment includes symptomatic treatment and supportive treatment. Need to keep the airways.

Brimonidine overdose symptoms such as apnea, slow heartbeat, coma, hypotension, lower body heat, reduced tone, sleeping, pale, respiratory failure and drowsiness have been reported in infants, young children and children treated with congenital glaucoma with alphagan or due to accidental drink.

What to do when you forget a dose? However, if close to the next dose, skip the forgotten dose and take the next dose at the time as planned. Do not drink twice as prescribed.

Side Effects

When using Alphagan, you may experience unwanted effects (ADR).

Common, ADR> 1/100

Eyes: allergic conjunctivitis, conjunctiva and itchy eye, burning sensation in the eyes, hyperpladier conjunctiva, dyeing / corneal corrosion, visual disorders, lash inflammation, eyelash inflammation, blurred vision, pale cataract, conjunctiva, conjunctiva, conjunctivitis, conjunctivitis, conjunctivitis, eye -catching, eye -catching, eye -catching, eye -catching, eye -catching, eye -eyed, eye -catching Eyes, eyelid edema, erythema in the eyelids, cystic conjunctivitis, feeling of exoticity in the eyes, corneal inflammation, eyelid disorders, stinging sensation in the eyes, fear of light, eye pity, shallow corneal disease, watery eyes, market damage, glass fluid, glass disorders, flying phenomena, vision loss.

digestive: dry mouth, digestive disorders .

Respiratory: bronchitis, cough, shortness of breath, influenza syndrome, infection (mainly cold and respiratory infections), rhinitis, sinusitis, sinusitis , sore throat.

nerve: Dizziness, headache , insomnia, drowsiness, fatigue.

Other: hypertension, allergic reactions, difficulty urinating, hypertension of blood, hypotension, rash.

Unknown frequency

Eyes: corneal corrosion

Other: insomnia, dry nose, drowsiness, deviation of taste.

Instructions on how to handle ADR

When experiencing side effects of the drug, it is necessary to stop using and notify the doctor or go to the nearest medical facility for timely treatment.

Warnings

Before using the drug you need to read the instructions carefully and refer to the information below.

contraindicated

Alphagan drugs contraindicated in the following cases:

Patients with hypersensitivity to Brimonidin Tartrat or other ingredients of the drug.

Patients who are using Mao inhibitors.

Infants and young children (under 2 years old).

Be cautious when using

children from 2 years and older, especially when weighing ≤ 20 kg, should be treated carefully and closely monitored due to the high incidence and the severity of drowsiness.

Although 0.15% Brimonidin Tartrat eye solution has very little effect on patients with clinical studies and heart rate in clinical studies, should be cautious when using alphagan in patients with serious vascular injections. There is no research on the influence of alphagan in patients with liver or kidney failure, so it is necessary to be cautious when used in these objects.

Be careful to use alphagan in depression patients, cerebral failure, coronary failure, raynaud phenomenon, hypotension with vertical posture, or inflammation of blood vessels.

Patients are indicated to use glaucoma drugs that need to be monitored for regular glaucoma.

The ability to drive and operate machinery

Alphagan can cause fatigue and/or drowsiness in some patients. For patients who are doing dangerous activities, they need to be cautious due to their ability to reduce mental alertness. Alphagan can also cause blurring or visual disorders in some patients. Patients should wait until these symptoms pass before driving or operating machinery.

Pregnancy

The teratogenic effect: Group b.

Brimonidin Tartrat does not cause teratogenicity when taking orally during pregnancy from Friday to the 15th day in the mouse and from the 6th to the 18th day in the rabbit. The highest dose of Brimonidin Tartrat used on rats (2.5 mg/kg/day) and on rabbits (5.0 mg/kg/day) gives AUC value achieved respectively 260 and 15 times this value in humans after dripping 1 drop of alphagan 0.15% at both eyes, 3 times/day.

There is no complete research and good control in pregnant women. In animal studies, Brimonidin passes the placenta and partially during the pregnancy. Alphagan should only be used for pregnant women when the mother's benefits are more than the risk of pregnancy.

The period of breastfeeding

It is unclear whether this drug can go through breast milk or not, although animal research shows that Brimonidin Tartrat is excreted through animal milk. Depending on the importance of this medication, it is advisable to consider for children to stop feeding or mothers stop taking the drug.

Drug interaction

Although studies on specific drug interactions with AlphaGan have not been conducted, it is necessary to consider the possibility of auxiliary effects or strengthen central neurological inhibitors (alcohol, barbiturates, opium, sedative or anesthetic). Alphagan is a substance that the alpha is a substance that can reduce vessels and blood pressure. Be careful when used simultaneously with drugs such as beta blockers (eye or whole body), anti -hypertension drugs and /or heart glycosides.

It is unclear whether the use of three -round antidepressants with Alphagan may interact with the effect of lowering pressure or not.

Storage

Store at a temperature not exceeding 30 degrees C.

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