Aluantine Tablet April treatment treatment of gastritis, increased secretion of stomach acid (10 blisters x 10 tablets)

Dosage form Box of 10 blisters x 10 tablets
Specifications Almagate
Ingredient Peptic ulcer, stomach reflux, heartburn

Ingredient

Composition information	Content
Almagate	500mg

Uses

indications

Aluantine Tablet is indicated for cases: gastritis, increased gastric acid secretion, support in the treatment of stomach - duodenal ulcer, reflux esophagitis.

Pharmacology

Almagat (AI2mg6 (OH) 14 (CO3) 2.4H2O, Aluminum - Magnesi Hydroxycarbonate) is an acid -resistant compound, capable of neutralizing hydrochloric acid and inhibiting the activity of pepsin.

Almagat has a strong acid -resistant effect. The amount of 1 g of neutralized almagat is 28 mmol HCI and 1.5 g of neutral almagat is 42-45 mmol HCI (by USP method). Testing on gastrointestinal fluid in healthy volunteers shows that almagat has the ability to neutralize hydrochloric acid in the stomach before and after stimulation with pentagastrin, and stop working of pepsin.

Compared to aluminum hydroxid, almagat increases pH more effectively, while reducing the total acidity of gastric juice faster without affecting the volume of secretion as well as no side effects causing constipation. Almagat also significantly inhibits pepsin's activity in gastric juice even after adjustment to pH equal to 2 is the optimal pH of pepsin. This ability is not seen in aluminum hydroxid.

In addition, Almagat also has the ability to cover evenly to create a protective film on the esophagus and stomach lining.

Dynamic pharmacokinetics

Almagat is not absorbed at the general circulation; Therefore, there is no need to identify standard pharmacokinetic parameters. After neutralizing hydrochloric acid in the stomach, almagat is excreted from the feces.

Magnesi

The drug starts to work as soon as hungry, the drug lasts for about 30 ± 10 minutes. If drinking at meals, or within 1 hour after eating, the effect lasts for about 1-3 hours. About 30% Magnesi is absorbed. Magnesi is less soluble in water, poorly absorbed compared to sodium bicarbonate so it does not cause alkaline infection. In people with renal failure, it is necessary to be cautious due to the ability to increase blood magnesium.

Due to changing gastric and urine pH, Magnesi anti -acid drugs change the speed of solubility and absorption, bioavailability and renal elimination of some drugs. Magnesi salt also tends to adsorb drugs and create an insoluble complex so it is not absorbed into the body. Magnesi eliminates the kidneys when normal kidney function. The part is not absorbed through feces.

aluminum

When taken, aluminum oxyd is slowly reacting with stomach hydrochloric acid to form soluble aluminum chloride. A small amount is absorbed into the body. Take the medicine at full to extend the reaction time of aluminum oxyd with stomach hydrochloric acid and increase the amount of aluminum chloride. About 17 - 30 % of aluminum chloride forms absorbed and eliminated very quickly through the kidneys in people with normal kidney function. In the small intestine, aluminum chloride is quickly converted into insoluble aluminum salts, malabsorption, can be a mixture of aluminum hydroxyd, oxyaluminum hydroxyd, alkaline aluminum carbonate and aluminum soap. Absorbed aluminum is excreted through urine. Therefore, patients with renal failure have many risks of accumulation of aluminum (especially in bones, central nervous systems) and aluminum poisoning. Aluminum absorbing will be attached to serum protein (such as albumin, transferrin) and therefore difficult to be removed by fertilizer.

Before taking Aluantine Tablet April treatment treatment of gastritis, increased secretion of stomach acid (10 blisters x 10 tablets)

How to use

oral medication.

Dosage

Adults

1 - 2 capsules 3 times/day, should be used after meals 30 minutes to 1 hour. In some cases, one more dose may be used before going to bed but should not exceed 8g/day.

Children (6 - 12 years)

1/2 adult dose.

Note: The above dose is for reference only. Specific dosage depends on the condition and level of progression of the disease. For a suitable dose, you need to consult a doctor or medical specialist.What to do when overdose?

Almagat is not absorbed into the blood. No toxicity has not been detected.

What to do when you forget a dose? However, if close to the next dose, skip the forgotten dose and take the next dose at the time as planned. Note that it should not be used double the prescribed dose.

Side Effects

When using Aluantine Tablet, you may experience unwanted effects (ADR).

constipation or diarrhea. This effect is usually mild and transient, disappearing after stopping treatment.

Instructions on how to handle ADR

When experiencing side effects of the drug, it is necessary to stop using and notify the doctor or go to the nearest medical facility for timely treatment.

Warnings

Before using the drug you need to read the instructions carefully and refer to the information below.

Contraindicated

Aluantine Tablet is contraindicated in the following cases:

Too hypersensitivity to almagat or any ingredient of the drug.

Do not take medication during pregnancy or lactation.

Caution when using

Patients with renal failure

Due to the lack of data on the use of preparations in patients with renal impairment, it is cautious when using this drug in patients with severe renal impairment, which has the risk of long -term accumulation of Magnesi and aluminum in the body.

Be cautious when used for patients with a diet with low phosphorus, patients with diarrhea, patients with poorly absorbed or depressed syndrome. Because aluminum tends to create phosphate salt difficult to dissolve in the intestine, leading to reducing the absorption of phosphate into the bloodstream.

In these patients, especially when prolonged treatment can cause a decrease in blood phosphate (anorexia, muscle weakness, discomfort ...) bone puree. Immediately notify doctors if there is any symptoms of gastrointestinal bleeding such as vomiting or bloody stools.

Precautions related to cancer, mutations and teratogen

When considering the possibility of ions absorbed into the blood when using almagat, the result of an animal study with a dose of up to 4 g/kg almagat does not show significantly increased serum concentration of aluminum and magnesium.

Although animal studies do not show evidence of the monster effect, this drug should not be used for pregnant women.

The ability to drive and operate machinery

does not have enough safety evidence when using almagat with drivers and operating machinery. Therefore, this drug should not be used for drivers and machinery.

Pregnancy

There is not enough safety evidence when using almagat with pregnant women. Therefore, this drug should not be used for pregnant women.

Breastfeeding period

does not have enough safety evidence when using almagat with nursing women. Therefore, this medication should not be used for breastfeeding women.

Drug interaction

should not use this drug with preparations containing tetracyclin, phenothiazin, digoxin, corticosteroids, isoniazid and iron salts because the drug can inhibit the absorption or change of the common use of shared drugs. This medication should be taken at least 1 hour after taking the above drugs. Increasing the gastrointestinal pH and body fluid can affect the absorption and excretion of the shared drug, so be cautious when used with other drugs.

Storage

Storage in closed packaging, avoid light and moisture, temperature below 30 ° C.

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