Alzental 400mg Shinpoong Daewoo treats one or more intestinal parasites (1 blister x 1 tablet)

Dosage form Film bag tablets
Specifications Box of 1 blister x 1 tablet
Ingredient Albendazol
Indication Casyworm infection, needle worm infection, eel worm infection, hairworm infection, hookworm infection
Contraindication Bone marrow poisoning, liver poisoning

Ingredient

Composition information	Content
Albendazol	400mg

Uses

indications

Alzental drugs are indicated in the following cases:

Treated an infection of one or many types of intestinal parasites such as roundworms, needle worms, hookworms, mine worms, wormworms, eelworms. Related to Mebendazol. The drug has a broad -active spectrum on intestinal worms such as hookworms (Ancylostoma duodenale), mine worms (Necator Americanus), roundworm (Ascaris lumbricoides), needle worms (enterobius vericularis), eelworm (Strongyloides stercoralis), Hairworm (Trichuris Trichurail) (Capillaria phippinensis); Curly worms (Trichinella Spiralis) and migration larvae in muscle and skin.

Albendazole is active in both adulthood and larval stage of intestinal worms and killing eggs of roundworms and hairworms. The main metabolic form of albendazol is Albendazol Sulfoxid still works and holds an important position of the pharmacological effect of the drug.

The mechanism of action of albendazole is similar to other benzimidazols. The drug is associated with the sub -parasites, thereby inhibiting the coincidence of the sub -sub -trailers into the minor minor microorganisms of the cytoplasm, which are essential for the normal activity of the parasite protection.

Dynamic pharmacokinetics

In humans, after drinking, Albendazol is very absorbed very poorly (5%). Most anti -helminth effects occur in the intestine. To have the effect of tissue, high and long -term doses must be used.

Due to a very strong step metabolism, albendazol does not see or only seen in the form of plasma streaks. After taking a single dose of 400 mg of albendazole, the peak concentration of sulfoxid metabolites is achieved in plasma about 0.04 - 0.55 micrograms/ml after 1 to 4 hours. When taking medicine with fat foods, plasma concentrations increase to 2-4 times. There is a great difference between individuals in albendazol sulfoxid levels in plasma. It may be due to erratic absorption and due to the difference in the speed of drug metabolism.

Albendazol Sulfoxid binds to protein in plasma up to 70%. When used for long -term use in the treatment of tapeworms, the concentration of albendazol sulfoxid in tapeworm fluid can reach about 20% of plasma concentrations. Albendazole sulfoxid through brain blood barrier and concentration in brain - marrow is about 1/3 of plasma concentrations.

Albendazole is rapid and completely oxidized, into a metabolic substance that still has the effect of Albendazol Sulfoxid, then converted into a compound no longer acting, Albendazol Sulfon.

Albendazole has half -life eliminated from plasma for about 9 hours. Sulfoxid metabolites are eliminated through the kidneys along with sulfon metabolites and other metabolites. A negligible amount of sulfoxid metabolism is excreted through bile.

Before taking Alzental 400mg Shinpoong Daewoo treats one or more intestinal parasites (1 blister x 1 tablet)

How to use

Take oral use.

Dosage

roundworm, needle worm, hookworm or hairworm

Adults and children> 2 years old: 400 mg/day.

Children

Take 1 single dose in 1 day. Can be treated after 3 weeks.

Larvae in da

Adults: Take 400 mg, 1 time, uong 3 days.

Children: Take 5 mg/kg/day, take 3 days.

strongyloides (worms)

Adults, children> 2 years: Take 400 mg/day/time for 3 days.

Children

Treatment can be repeated after 3 weeks.

Note: The above dose is for reference only. Specific dosage depends on the condition and level of progression of the disease. For a suitable dose, you need to consult a doctor or medical specialist.

What to do when using overdose?

What to do when you forget a dose? However, if close to the next dose, skip the forgotten dose and take the next dose at the time as planned. Note that it should not be used double the prescribed dose.

Side Effects

When using Alzental, you may experience unwanted effects (ADR).

When treating for a short time (

Usually unwanted effects are not severe and recover without treatment. Only stop treatment when leukocyte or liver abnormalities.

Common side effects, ADR> 1/100

Fever, headache, dizziness, brain manifestation, increased pressure in the brain, abnormal liver function, abdominal pain, nausea, vomiting, hair loss (recovery).

Side side effects, 1/1000

allergic reactions, leukopenia, skin rash, urticaria, acute renal failure.

Rare side effects, ADR

Granulocytosis, general hemorrhage, grain leukemia, thrombocytopenia.

Instructions on how to handle ADR

When experiencing side effects of the drug, it is necessary to stop using and notify the doctor or go to the nearest medical facility for timely treatment.

Warnings

Before using the drug you need to read the instructions carefully and refer to the information below.

Contraindicated

Alzental drugs contraindicated in the following cases:

There is a history of hypersensitivity to benzimidazol compounds or some of the drug ingredients.

Patients with a history of bone marrow poisoning.

Pregnant women.

Be cautious when using

Patients with abnormal liver function before starting treatment with albendazole need to consider needing kidney because the drug is metabolized in the liver and has seen a few people with liver poisoning. Also be cautious with people with blood.

The ability to drive and operate machinery

Side effects such as dizziness, headache may occur. If occurred, patients should not drive or operate machinery.

Pregnancy

should not use albendazol for pregnant women except for cases of mandatory use without any other way. The patient must not be pregnant for at least a month after using albendazol. If the patient is taking the drug and if he is pregnant, he / she must stop the drug immediately and must understand that the drug can cause serious danger to the fetus.

The period of breastfeeding

It is unknown how much the medicine is in breast milk. Therefore, it is necessary to be very careful when using albendazol for nursing women.

Drug interaction

dexamethason: The lowest stable concentration in the plasma of Albendazol Sulfoxid is about 50% higher when used in combination with 8 mg of dexamethasone with each dose of albendazol (15 mg/kg/day).

Praziquantel: Praziquantel (40 mg/kg) increases the average concentration in plasma and area under the curve of Albendazol Sulfoxid about 50% compared to the single albendazole (400 mg).

cimetidine: Albendazol sulfoxid concentration in bile and in fluka fluid increased by about twice in people with cysts when used in combination with cimetidine (10 mg/kg/day) compared to using single albendazole (20 mg/kg/day).

Theophylin: The pharmacokinetics of theophylin (transmitted for 20 minutes theophylin 5.8 mg/mg) does not change after taking 1 albendazol (400 mg).

Storage

Store in closed packaging, avoid light, in a dry place temperatures below 30 ° C.

Other drugs

Disclaimer

Every effort has been made to ensure that the information provided by Drugslib.com is accurate, up-to-date, and complete, but no guarantee is made to that effect. Drug information contained herein may be time sensitive. Drugslib.com information has been compiled for use by healthcare practitioners and consumers in the United States and therefore Drugslib.com does not warrant that uses outside of the United States are appropriate, unless specifically indicated otherwise. Drugslib.com's drug information does not endorse drugs, diagnose patients or recommend therapy. Drugslib.com's drug information is an informational resource designed to assist licensed healthcare practitioners in caring for their patients and/or to serve consumers viewing this service as a supplement to, and not a substitute for, the expertise, skill, knowledge and judgment of healthcare practitioners.

The absence of a warning for a given drug or drug combination in no way should be construed to indicate that the drug or drug combination is safe, effective or appropriate for any given patient. Drugslib.com does not assume any responsibility for any aspect of healthcare administered with the aid of information Drugslib.com provides. The information contained herein is not intended to cover all possible uses, directions, precautions, warnings, drug interactions, allergic reactions, or adverse effects. If you have questions about the drugs you are taking, check with your doctor, nurse or pharmacist.