Alzole 40mg TV.Pharm Treatment of esophagitis, stomach ulcers, duodenum (3 blisters x 10 tablets)

Dosage form Box of 3 blisters x 10 tablets
Specifications Omeprazol
Ingredient Gastrointestinal ulcers, gastroesophageal reflux, Zollinger-Elison syndrome

Ingredient

Composition information	Content
Omeprazol	40mg

Uses

indications

Alzole drugs are indicated in the following cases:

Treatment of esophagitis due to gastroesophageal reflux - esophagus. and reduces gastric acid secretion.

Dynamic pharmacokinetics

Alzole is completely absorbed in the small intestine after drinking for 3-6 hours. Biological use is about 60%, food does not affect the absorption of the drug in the intestine. The absorption of the drug depends on the dose, the drug may increase its absorption and increase its biodiversity due to inhibition of acid secretion of the stomach, the drug is highly attached to plasma proteins (about 95%), and is distributed to tissues, especially in stomach border cells.

Biological use of the first oral dose is about 35% low, but will increase to 60% if taken by the next day, the sale time is 40 minutes, but the inhibitory effect is prolonged acid excretion, so it can be used once a day.

Alzole is completely transferred in the liver, quickly excreted through the urine (about 80%), the rest through the feces, the metabolites are not active, but interact with many other drugs due to inhibition of enzymes of the cytochrom P450 of liver cells.

The pharmacokinetics of the drug change does not make sense in the elderly or the impaired renal function, in the liver failure, the bioavailability of the increased drug and the clearance of the drug decreases, but there is no accumulation of drugs and metabolites.

Before taking Alzole 40mg TV.Pharm Treatment of esophagitis, stomach ulcers, duodenum (3 blisters x 10 tablets)

How to use

Take oral use.

Dosage

esophagitis due to gastroesophageal reflux - esophagus:

Take 20 - 40 mg/time/day, for 4 - 8 weeks.

duodenal ulcer:

Progressive duodenal ulcer: 20 - 40 mg/time/day, for 4 - 8 weeks.

Alzole is used in combination with clarithromycin or clarithromycin and amoxycilin to eliminate H. pylori.

Dosage recommended: 40 mg Alzole x 1 time/day + 500 mg Clarithromycin x 3 times/day, in 14 days, in patients with ulcers in the early stages of treatment, need to take Alzole 20 mg/time/day, for 14 days to heal ulcers.

When taking high doses, it is not allowed to stop the drug suddenly but must decrease.

Stomach ulcer:

oral 40 mg/time, 4 - 8 weeks.

Treatment of Zollinger-Elision syndrome:

Take 20-120 mg/time/day. If the dose is higher than 80 mg should be divided 2 times/day. Dosage and therapeutic time depending on clinical requirements. Do not stop the drug suddenly.

Note: The above dose is for reference only. Specific dosage depends on the condition and level of progression of the disease. For a suitable dose, you need to consult a doctor or medical specialist.

What to do when overdose?

When overdose, only symptomatic treatment, no specific treatment.

What to do when you forget a dose? However, if close to the next dose, skip the forgotten dose and take the next dose at the time as planned. Do not drink twice as prescribed.

Side Effects

When using Alzole, you may experience unwanted effects (ADR).

Common, ADR> 1/100

Mental: headache, drowsiness, dizziness.

digestive: Nausea, vomiting, abdominal pain, constipation, abdominal distention.

Uncommon, 1/1000

Mental: Insomnia, sensory disorders, dizziness, fatigue.

Body: urticaria, itching, rash, temporary increase of transaminase.

Metabolism: temporarily increased transaminase.

Rare, 1/10000

Body: sweating, peripheral edema, hypersensitivity including, angioedema, fever, anaphylaxis.

Hematology: leukopenia, thrombocytopenia, reducing all blood cells, foreign rash, loss of granulocytes. nerve: Confusion has recovery, agitation, depression, hallucinations in elderly patients, especially in serious patients, hearing disorders.

Endocrine: Big breasts in men.

digestive: gastritis, candidiasis infection, dry mouth. liver: jaundice or no jaundice, cerebral disease in people with liver failure. Respiratory: Bronchospasm.

Muscle muscle: joint pain, muscle pain.

Urine: interstitial nephritis.

Instructions on how to handle ADR

Notify the doctor the side effects encountered when using the drug.

Warnings

Before using the drug you need to read the instructions carefully and refer to the information below.

Contraindicated

Alzole drugs are contraindicated in cases of sensitivity to any ingredient of the drug.

Be cautious when using

Alzole can hide symptoms and slow down the diagnosis in patients with malignant damage in the stomach.

The ability to drive and operate machinery

The drug can cause dizziness, so it is cautious when used in drivers and operating machinery.

Pregnancy

There is no impact data for drugs on pregnant women. So avoid for pregnant women.

The period of breastfeeding

There is no impact data for drugs on nursing women. So avoid for women breastfeeding.

Drug interaction

Alzole increases blood ciclosporin levels.

Alzole increases the effects of antibiotics in h.pylori eradication.

Alzole inhibits the metabolic of drugs metabolized by the enzyme system in the liver's cytochrom P450 and can increase the concentration of diazepam, phenytoin, and warfarin in the blood. The metabolism of diazepam makes the effect of the drug longer. With a dose of 40 mg/day, Alzole inhibits the metabolism of phenytoin and increases the concentration of phenytoin in the blood. Alzole inhibits the metabolism of warfarin but rarely changes bleeding time.

Alzole increases Dicoumarol's anticoagulant effect.

Alzole reduces nifedipine metabolism at least 20% and can increase the effects of nifedipine.

Clarithromycin inhibits alzole metabolism and makes the alzole concentration doubled.

Storage

Store in a dry place, less than 300C, avoid light.

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