Amefu Day Time OPV drugs reduce symptoms of colds and flu (10 blisters x 10 tablets)

Dosage form Box of 10 blisters x 10 tablets
Specifications Acetaminophen, Guaifenesin, phenylephrine, dextromethorphan
Ingredient OPV

Ingredient

Thành phần cho 1 viên

Composition information	Content
Acetaminophen	500mg
Guiifenesin	200mg
Phenylephrine	10mg
Dextromethorphan	15mg

Uses

Indications

Amefu Day Time is indicated in the following cases: Reducing symptoms in colds and flu such as fever, cough, pain, sore throat, headache, nasal congestion (stuffy nose), dilute phlegm (mucus) and dilute bronchial fluid to make it easier to cough.

Pharmacokological

acetaminophen is a metabolic substance that has the activity of phenacetin, which helps to relieve pain by preventing peripheral pain pulse arising. The drug has an antipyretic effect by inhibiting the central thermostat in the hypothalamus.

Guaifenesin is a long -lasting drug, which promotes or easily eliminates the excreted substances from the respiratory tract.

Phenylephrine hydrochloride is a sympathetic neuropathy that works directly on the receptors of Alpha - 1 Adrenergic causing vasoconstriction, reducing nasal congestion and sinuses.

dextromethorphan hydrobromide is a cough, effect on cough center in the onion. The drug has no pain to relieve pain and sedative effects.

pharmacokinetics

Acetaminophen is quickly absorbed from the digestive tract with peak plasma concentrations reaching about 30-60 minutes after drinking. Acetaminophen is distributed in most body tissues. Acetaminophen through the placenta and present in breast milk. The drug associated with plasma protein is negligible at conventional treatment levels but the cohesion rate will increase as the concentration increases. The half -life of acetaminophen changes about 1–3 hours.

Acetaminophen is metabolized mainly in the liver and excreted in urine mainly in the form of glucuronide complex (60 - 80%) and sulfate complex (20 - 30%). Under 5% is excreted in the form of unchanged acetaminophen. A small part (less than 4%) is metabolized through the Cytochrome P450 system.

Guaifenesin is well absorbed through the gastrointestinal tract. The drug is metabolized and then eliminated through the urine.

Phenylephrine hydrochloride is abnormal absorbed through the gastrointestinal tract and undergoing the early stages metabolism in the intestine and liver thanks to the enzyme monoamine oxidase. Phenylephrine is excreted almost entirely through urine.

dextromethorphan hydrobromide is quickly absorbed through the digestive tract and works within 15 - 30 minutes after drinking, lasting about 6-8 hours. The drug is metabolized in the liver and the issue in the urine in the form of unchanged and the Demethyl metabolites include Dextrophan, which also reduces cough.

Before taking Amefu Day Time OPV drugs reduce symptoms of colds and flu (10 blisters x 10 tablets)

How to use

Oral drugs.

Dosage

Adults and children 12 years and older: Take 1 capsule, every 6 hours. Do not use more than 6 tablets/24 hours.

Children 6 - 11 years old: Take 1/2 tablets every 6 hours. Do not use more than 3 tablets/24 hours.

Note: The above dose is for reference only. Dosage to treat the flu with Ameflu specific depends on the condition and level of progression of the disease. For a suitable dose, you need to consult a doctor or medical specialist.

What to do when overdose? Acetylcysteine protects the liver if used for about 24 hours from the overdose of acetaminophen (most effective if used for about 8 hours). The first dose is 140mg/kg (loading dose), then giving 17 more doses, each dose of 70mg/kg 4 hours apart. Activated carbon or gastric wash can be done to reduce the absorption of acetaminophen.

phenylephrine hydrochloride: symptomatic and supportive treatment.

Dextromethorphan: Supporting and symptomatic treatment. It is possible to use naloxone 2mg intravenously, repeated if necessary.

Overdose of Guaifenesin does not cause life -threatening symptoms.

In case of overdose, immediately contact the doctor or go to the nearest hospital.

What to do when you forget a dose? However, if close to the next dose, skip the forgotten dose and take the next dose at the time as planned. Note that it should not be used double the prescribed dose.

Side Effects

When using Ameflu Day Time, you may experience unwanted effects (ADR).

Some cases of allergies to drugs rarely occur such as skin rash, erythema, urticaria, thrombocytopenia, liver failure. Another side apples may be restless, insomnia, hypertension, arrhythmia, dizziness, nausea, vomiting, stomach irritation, tremor, weakness, hallucinations and shortness of breath.

Instructions on how to handle ADR

When experiencing side effects of the drug, it is necessary to stop using and notify the doctor or go to the nearest medical facility for timely treatment.

Warnings

Before using the drug you need to read the instructions carefully and refer to the information below.

Contraindicated

Amefu day Time drug is contraindicated in the following cases:

Hypersensitivity to any ingredients of the drug.

Be cautious when using

When taking the drug contains acetaminophen, the newspaper should warn the patient about serious signs of the skin reaction such as Stevens - Johnson syndrome (SJS), toxic skin necrosis syndrome (Ten), or Lyell syndrome, acute foreign pustular syndrome (AGEP).

Not used with other drugs containing acetaminophen.

Consult your doctor if you have cardiovascular disease, liver disease, diabetes, hyperthyroidism, cough a lot of talks, hypertension, kidney failure, glaucoma, urinary difficulty due to prostate hypertrophy and chronic coughs due to smoking, bronchitis, chronic bronchitis or bronchitis.

Stop taking medication and consult a doctor if there are new symptoms, redness or swelling, pain, nasal congestion, more severe cough or lasting more than 7 days, fever worse or lasting more than 3 days, feeling restless, dizziness or insomnia, recurrent cough or fever, skin rash or long -lasting headache. This may be a sign of worse pathology.

The ability to drive and operate machinery

Use carefully while driving or operating machinery.

Pregnancy

should consult a doctor before taking this medication.

Breastfeeding period

should consult a doctor before taking this medication.

Medicinal interaction

Do not use Ameflu Day Time if you are taking Monoamine Oxidase inhibitors (Maois) (several treatments for depression, mental or emotional disease or Parkinson's disease) or within 2 weeks after stopping using Maois drugs. If you do not know whether the drug is taking as prescribed by a doctor containing Maois or not, you must consult your doctor or pharmacist before taking Ameflu Day Time.

Anti -seizures (including Phenytoin, Barbiturate, Carbamazepine), Isoniazid may increase the toxicity of acetaminophen on the liver.

Simultaneous use of phenylephrine with amine -like sympathetic nerve effects can increase cardiovascular effects on cardiovascular effects.

Phenylephrine may reduce the effectiveness of beta blockers and anti -hypertension drugs (including debilisquine, guanethidine, reserpine, methyldopa). The risk of hypertension and unwanted effects on the heart can increase.

The antidepressants (Amitriptyline, imipramine) may increase the unwanted effects of phenylephrine.

Simultaneous use of phenylephrine with mushroom alcaloid (ergotamine and methylsergide) increases the poisoning of chicken spurs. Simultaneous use of phenylephrine with digoxin increases the risk of abnormal heart rate or heart attack.

Simultaneous use of phenylephrine with atropine will block the slow effect of the reflective heart rate caused by phenylephrine.

Storage

At temperatures below 30 ° C, in a dry place, avoiding light.

Other drugs

Disclaimer

Every effort has been made to ensure that the information provided by Drugslib.com is accurate, up-to-date, and complete, but no guarantee is made to that effect. Drug information contained herein may be time sensitive. Drugslib.com information has been compiled for use by healthcare practitioners and consumers in the United States and therefore Drugslib.com does not warrant that uses outside of the United States are appropriate, unless specifically indicated otherwise. Drugslib.com's drug information does not endorse drugs, diagnose patients or recommend therapy. Drugslib.com's drug information is an informational resource designed to assist licensed healthcare practitioners in caring for their patients and/or to serve consumers viewing this service as a supplement to, and not a substitute for, the expertise, skill, knowledge and judgment of healthcare practitioners.

The absence of a warning for a given drug or drug combination in no way should be construed to indicate that the drug or drug combination is safe, effective or appropriate for any given patient. Drugslib.com does not assume any responsibility for any aspect of healthcare administered with the aid of information Drugslib.com provides. The information contained herein is not intended to cover all possible uses, directions, precautions, warnings, drug interactions, allergic reactions, or adverse effects. If you have questions about the drugs you are taking, check with your doctor, nurse or pharmacist.