Aminoplasmal intravenous solution 10% B.Braun provides amino acids (250ml)

Dosage form 10 bottles x 250ml
Specifications Isoleucine, leucine, lysine, methionine, phenylalanine, threonine, tryptophan, valine, arginine, histidine, glycine, alanine, proline, aspartic acid, sodium acetate trihydrate, cysteine, glutamic acid, ornithine, serine, tyrosine, sodi, sodi
Ingredient Reducing blood protein

Ingredient

Composition information	Content
Isoleucine	1.25g
Leucine	2.225g
Lysine	1,7125g
Methionine	1.1g
Phenylalanine	1.175g
Threonine	1.05g
Tryptophan	0.4g
Valine	1.55g
Arginine	2.875g
Histidine	0.75g
Glycine	3G
Alanine	2.625g
Proline	1.375g
Aspartic Acid	1.4g
Sodium acetate trihydrate	0.7145g
Cysteine	0.295g
Glutamic acid	2.85g
Ornithine	0.65g
Serine	0.575g
Tyrosine	0.1g
Sodium hydroxide	0.09g
Potassium Acetate	0.61325g
Magnesium chloride hexahydrate	0.127g

Uses

Indications

Aminoplasmal 10% 250ml are indicated in the following cases:

Provides amino acids as a substrate for protein synthesis in nourishing mode through intravenous tract, when nourished through oral and gastrointestinal tract cannot be done, not enough or contraindicated.

Pharmacokic of

The purpose of the intravenous nutrient solution is to provide essential nutrients for the development, maintenance and restoration of the body's tissue.

Amino acids are transmitted through intravenously into the vein and join the amino acid fund for free endogenous acid inside the cell. Both endogenous and external amino acids are used as a substrate for the synthesis of function protein and structure of the body.

To avoid the metabolism of amino acids producing energy and also to provide other energy consumption processes of the body, should be used with energy suppliers (in the form of carbohydrates or fat).

The electrolyte is used in intravenous nutrition to maintain the serum needed for the physiological process of the cell. In addition, the combination of electrolytes with amino acids is beneficial, due to the interiority of each substance.

pharmacokinetics

Because aminoplasmal 10% 250ml is transmitted through intravenously, the bioavailability of amino acids and electrolytes reaches 100%.

Amino acid components of aminoplasmal 10% 250ml are set on the basis of clinical research results on the concentration of amino acids in plasma when transmitting amino acids. In aminoplasmal 10% 250ml of concentration of each amino acid selected so that when the solution is transmitted, the relative increase of amino acids in plasma is even as well as possible. This means that the lipstick of amino acids in plasma is maintained as long as possible when transmitting aminoplasmal 10% 250ml.

The amino acid part is not involved in the synthesis of protein metabolized as follows: The amino acid group is separated from the carbon frame by the amine metabolism, the carbon chain or is directly oxidized into CO2 or used as a substance in the process of forming glucose in the liver, the amine group is also metabolized in the liver into urea.

Before taking Aminoplasmal intravenous solution 10% B.Braun provides amino acids (250ml)

How to use

Medicine using central intravenous line.

Aminoplasmal 10% 250ml is only a component of intravenous nutrition. In intravenous nutrition, amino acid supply must be combined with providing energy sources, essential fatty acids, vitamins and trace elements.

Dosage

Dosage is adjusted according to the needs of each patient about amino acids, electrolytes and body fluids, depending on the clinical conditions of the patient (nutritional status or the level of nitrogen catabolic due to pathology).

adults and adolescents 15 - 17 years old

Average daily dose

Use 10 - 20ml/kg.

equivalent: 1.0 - 2.0g amino acid/kg.

equivalent: 700–1400ml for patients weighing 70kg.

Maximum daily dose

Use 20ml/kg.

equivalent: 2.0g amino acid/kg.

equivalent: 140g amino acid for patients weighing 70kg.

equivalent: 1400ml for patients weighing 70kg.

Maximum transmission speed and drops: 1.0ml/kg body weight/hour.

Equivalent: 0.1g amino acid/kg/hour.

Equivalent: 25 drops/minute for patients weighing 70kg.

equivalent: 1.17ml/minute for patients weighing 70kg.

Children and teenagers until the age of 14

Daily dose for children 3-5 years old

Use 15ml/kg/day and equivalent to 1.5g amino acid/kg/day.

Daily dose for children 6 - 14 years old

Use 10ml/kg/day and equivalent to 1.0g amino acid/kg/day.

Maximum transmission speed: 1.0ml/kg/hour, corresponding to 0.1g of amino acid/kg/hour.

Note: The above dose is for reference only. Specific dosage depends on the condition and level of progression of the disease. For a suitable dose, you need to consult a doctor or medical specialist.

What to do when overdose?

Treatment: If the reaction does not absorb, it is necessary to stop transmitting temporarily and then continue to transfer it at a lower speed

What to do when you forget a dose? However, if close to the next dose, skip the forgotten dose and take the next dose at the time as planned. Note that it should not be used double the prescribed dose.

Side Effects

When using aminoplasmal 10% 250ml , you may experience unwanted effects (ADR).

Uncommon, 1/1000

Digestive: Nausea, vomiting.

Other ADR: headache , chilling, fever.

Instructions on how to handle ADR

Notify the doctor with unwanted effects when using the drug. With minor adverse reactions, usually just stop the drug. In case of severe sensitivity or allergic reactions, supportive treatment (airy keep and use epinephrine , oxygen breathing, antihistamine, corticoid ...).

Warnings

Before using the drug you need to read the instructions carefully and refer to the information below.

Contraindicated

Aminoplasmal 10% 250ml contraindicated in the following cases:

sensitive to amino acids present in solution.

Metabolism of abnormal amino acids.

Serious circulatory disorders threaten to life, for example shocking.

Hemolytic reduction.

Metabolic acid infection.

Progressive liver disease.

Severe kidney failure is not dialysis or hemorrhage.

Pathological or high serum concentration of any electrolyte in the product composition.

Children under 2 years old.

General contraindications in intravenous infusion: heart failure unsaturated, acute pulmonary edema, water stasis.

Caution when using

Aminoplasmal 10% 250ml is used carefully and only after careful consideration between expected benefits and potential risks in patients with amino acid metabolic disorders due to the causes in addition to the causes mentioned in the "Commandment" section.

In patients with liver failure, renal failure must be adjusted for each patient.

Be careful to check patients with increased serum osmotic pressure.

In case of dehydration, adjustment should be adjusted by providing enough fluid and electrolytes before using intravenous nutrient solution.

During the treatment process, there must be regular monitoring of serum, blood sugar, liquid balance, acid -base balance, kidney function (bun, creatinine).

Should control serum protein and test liver function.

Should be cautious when transmitting a large amount of fluid to patients with heart failure.

Should check daily in the position of catheter signs of inflammation or infection.

The ability to drive and operate machinery

No.

Pregnancy

Classification of drugs for pregnant women under the Australian Drug Administration (TGA): Na.

Classification of drugs for pregnant women under the US Food and Drug Administration (FDA): Na.

No research in pregnant women has not been conducted. There is no clinical data related to the use of aminoplasmal 10% 250ml during pregnancy.

Should only use aminoplasmal 10% 250ml for pregnant women after careful evaluation of the benefits and risks possible.

Breastfeeding period

has not conducted research in nursing women.

Should only use aminoplasmal 10% 250ml for breastfeeding women after careful evaluation of benefits and risks possible.

Drug interaction

No information.

Storage

The solution after mixing must be used immediately. If not used immediately, the time and conditions of the solution after mixing are responsible for the user and often must not exceed 24 hours at 2 - 8 ° C.

Special warning in storage.

Keep the bottle in carton to avoid light.

Do not leave the medicine at a temperature of over 30 ° C.

No cold storage.

Storage less than 15 ° C can lead to crystal form, dissolved when heating up to 30 ° C. Stir the bottle gently to homogeneous mixture when heating.

Special warning when processing and shipping.

Do not use if the solution is not transparent or if the bottle or bottle cap shows signs of damage.

Must use aseptic transmission line.

Each bottle is only used once. The non -used part must be canceled and not to use for the next time.

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