Aminoplasmal intravenous solution 10% B.Braun provides amino acids (500ml)

Dosage form 10 bottles
Specifications Isoleucine, leucine, lysine, methionine, phenylalanine, threonine, tryptophan, valine, arginine, histidine, glycine, alanine, proline, aspartic acid, asparagine, cysteine, glutamic acid, ornithine, serine, tyrosine
Ingredient Crohn's disease, cystic fibrosis, hypoglycemia

Ingredient

Composition information	Content
Isoleucine	4.4g
Leucine	6.8g
Lysine	3.755g
Methionine	0.6g
Phenylalanine	0.8g
Threonine	2.3g
Tryptophan	0.75g
Valine	5.3g
Arginine	4.4g
Histidine	2.35g
Glycine	3.15g
Alanine	4.15g
Proline	3.5g
Aspartic Acid	1.25g
Asparagine	0.24g
Cysteine	0.295g
Glutamic acid	2.85g
Ornithine	0.65g
Serine	1.85g
Tyrosine	0.35g

Uses

Indications

Aminoplasmal is indicated in the following cases:

Provide amino acids as a substrate for protein synthesis in nourishing mode through intravenous tract, when nourished through oral and digestive tract cannot be done, insufficient or contraindicated.

In intravenous nurturing, always transmitting amino acid solutions in combination with an appropriate amount of energy solution, for example, carbohydrate solutions.

Pharmacy

Classification: Nutrition solution through intravenously.

ATC Code: B05B A10.

The purpose of intravenous nutrient solution is to provide essential nutrients for the development, maintenance and restoration of body tissues.

Amino acids are of special importance because they are an essential part of protein synthesis. Amino acids are transmitted through intravenously into the veins and join the fund of the endogenous amino acids inside the cell. Both endogenous and exaggerated amino acids are used as a substrate for the synthesis of function protein and structure of the body.

To avoid the metabolism of amino acids producing energy, and also to provide other energy consumption of the body, should be used with energy supply substances (in the form of carbohydrates or fat).

Electrolytes used in intravenous nutrition help maintain the serum needed for the physiological process of the cell that the electrolyte level in the cell is closely adjusted as a prerequisite. In addition, the combination of electrolytes with amino acids is beneficial, due to the independent of each substance that depends on each other

pharmacokinetics

Due to aminoplasmal B. Braun 10% E is transmitted through intravenous lines, the bioavailability of amino acids and electrolytes reaches 100%.

Amino acids components of aminoplasmal B. Braun 10% E are established on the basis of clinical research results on the concentration of amino acids in plasma when transmitting amino acids. In Aminoplasmal B. Braun 10% E The concentration of each amino acids has been selected so that when transmitting that solution, the relative increase of amino acids in plasma is even as well as possible. This means that the lipstick of amino acids in plasma is maintained as long as possible when transmitting aminoplasmal B. Braun 10% E.

The amino acids part is not involved in the synthesis of protein metabolized as follows. The amino acids group is separated from the carbon frame by amino metabolism. Carbon or oxidized chain directly into CO2 or used as a substrate during the formation of glucose in the liver. The amino group is also transformed in the liver into urea.

Before taking Aminoplasmal intravenous solution 10% B.Braun provides amino acids (500ml)

How to use

Methods of transmission and use time: central intravenous infusion.

Amino acid solution can be used every time the nutrition is specified.

Aminoplasmal B. Braun 10% E is only a component of intravenous nutrition. In intravenous nutrition, supplying amino acids must be combined with providing energy sources, essential fatty acids, vitamin and trace elements.

Dosage

Dosage is adjusted according to the needs of each patient about amino acids, electrolytes and body fluids, depending on the clinical conditions of the patient (nutritional condition or the level of nitrogen catabolic due to pathology).

Dosage for adults and adolescents from 15 - 17 years old

Average daily dose

10 - 20ml/kg body weight. Equivalent to 1.0 - 2.0g amino acid/kg body weight or equivalent: 700 - 1400ml for patients weighing 70kg.

Maximum daily dose

20ml/kg body weight.

equivalent: 2.0g amino acid/kg body weight.

Equivalent: 140g amino acids for patients weighing 70kg.

or equivalent: 1400ml for patients weighing 70kg.

Maximum transmission speed and drops

1.0ml/kg body weight/hour

Equivalent: 0.1g amino acid/kg body weight/hour or equivalent: 25 drops/minute for patients weighing 70kg.

equivalent: 1.17ml/ minute for patients weighing 70kg.

Dosage for children and teenagers to 14 years old.

The recommended dose given here is the average value of orientation. The dose must be corresponding to the age of each patient, the stage of development of the disease and the disease.

daily dose for children from 3 to 5 years old

15ml/kg body weight/day and equivalent to 1.5 g of amino acid/kg body weight/day.

Daily dose for children from 6 - 14 years old

10ml/kg body weight/day and equivalent to 1.0g amino acid/kg body weight/day.

Maximum transmission speed: 1.0 ml/kg body weight/hour, corresponding to 0.1 g of amino acid/kg body weight/hour.

What to do when overdose?

If the reaction is not absorbed, it is necessary to stop transmitting temporarily and then continue to transfer it at a lower speed.

What to do when you forget the dose? However, if close to the next dose, skip the forgotten dose and take the next dose at the time as planned. Do not drink twice as prescribed.

Side Effects

Has unwanted effects, but the side effects are not specific to this product but may appear as the results of venous nurturing, especially at the beginning stage.

Less (

Gastrointestinal disorders : Nausea, vomiting.

general disorder: headache , chilling, fever.

Instructions on how to handle ADR

When experiencing side effects of the drug, it is necessary to stop using and notify the doctor or go to the nearest medical facility for timely treatment.

Warnings

Contraindicated

Aminoplasmal drug contraindicated in the following cases:

Sensitive to Amino Acids is present in the solution.

Metabolism of abnormal amino acids.

Serious circulatory disorders that are life -threatening, for example shocking.

Hemolytic reduction.

Metabolic acid infection.

Progressive liver disease.

Severe kidney failure is not dialysis or hemorrhage.

Pathological or high serum concentration of any electrolyte in the product composition.

Children under 2 years old.

Commonly contraindicated in intravenous infusion:

Uncount heart failure.

Acute pulmonary edema.

Conditions of water.

Precautions when taking the drug

Aminoplasmal is used carefully and only after careful consideration between expected benefits and potential risks in patients with amino acids metabolic disorders due to other causes other than the causes mentioned in the "anti -contrapeination" section:

In patients with liver failure, renal failure must be adjusted for each patient.

Be careful to check patients with serum osmotic pressure.

In case of dehydration, adjustment should be adjusted by providing sufficient fluid and electrolytes before using intravenous nutrient solution.

During the treatment process, there must be regular monitoring of serum, blood sugar, liquid balance, acid-base balance, renal function (bun, creatinin).

Should also control serum protein and test liver function.

should be careful when transmitting a large amount of fluid to patients with heart failure .

Aminoplasmal can be used as a part of the total venous nourishment when combining the appropriate amount of energy supplements such as (carbohydrate solution, fat emulsion), vitamins, trace elements.

If the aminoplasmal is used in combination with other nutrient solutions, peripheral intravenous transmission capacity depends on the osmotic pressure of the mixed solution.

Should check daily in the position of transmitting signs of inflammation or infection.

The ability to drive and operate machinery

There has been no report on driving and operating machinery when treated with aminoplasmal.

Pregnancy and lactation

have not conducted research in pregnant and lactating women. There is no preclinical data related to the use of aminoplasmal B. Braun 10% E during pregnancy.

Should only take aminoplasmal medicine for pregnant and lactating women after careful evaluation of benefits and risks possible.

Medicinal interaction

No reports on aminoplasmal drug interaction.

Storage

Expiry date

Expiry date without opening: 36 months from the date of manufacture.

Expiry date: The drug after opening the lid must be used immediately. From the viewpoint of germs, the solution after mixing must be used immediately. If not used immediately, the time and conditions of preserving the solution after mixing belong to the responsibility of the user and often not to exceed 24 hours at 2 - 8 ° C.

Special warning in storage

Keep the bottle in carton to avoid light.

Do not leave the medicine at a temperature of over 30 ° C.

No cold storage.

Storage less than 15 ° C can lead to crystalline crystallization, but it is easy to dissolve when heating up to 30 ° C temperature until the solution is completely dissolved. Shake the bottle gently to homogeneous mixture when heating.

Special warnings when processing and shipping

Do not use if the solution is not transparent or if the bottle and the lid show signs of damage.

Must use aseptic transmission line.

Each bottle is only used once. The non -used part must be canceled and not to use for the next time.

If necessary to add other nutrients such as carbohydrates, lipids, vitamins and trace elements to this drug to provide nutritious venous nutrition, the mixing process must be done under strict sterile conditions. The mixing should be completely mixed and must check the compatibility of the added substances.

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