Amitriptylin 25mg Danapha drug treatment (100 tablets)

Dosage form Box of 100 capsules
Specifications Amitriptyline
Ingredient Bedwetting, depression

Ingredient

Composition information	Content
Amitriptyline	25mg

Uses

indications

Amitriptylin 25mg is indicated in the following cases:

Treatment of depression, especially endogenous depression (mental disorder of depression). The drug has little effect on response depression. The mechanism of action of Amitriptyline is to inhibit the re -import of monoamine, serotonin and noradrenalin in Monoaminergic neurons.

Noradrenalin re -entry effect is considered to be related to the antidepressant effect of the drug. Amitriptyline also has anti -cholinergic effects in both central and peripheral nerves.

Dynamic pharmacokinetics

Absorption: Amitriptyline absorbs quickly and completely after the intramuscular injection for 5-10 minutes and after drinking 30-60 minutes.

Distribution: Amitriptyline is widely distributed throughout the body and is highly linked to plasma and tissue proteins.

Metabolism and elimination: With the usual dose, 30-50% of the drug is excreted within 24 hours. Amitriptyline metabolizes by reducing N - methyl and hydroxylation. In fact, all the dose of the drug eliminates in the form of glucuronid or sulfate conjugate metabolites. A very small amount of Amitriptyline is not metabolized in urine.

The half -life of Amitriptyline is about 9 to 36 hours. There are very few amitriptyline in the form of no metabolism excreted through urine. There is much difference in plasma concentrations between individuals after taking a normal dose. The reason for this difference is that half -life in the plasma of the drug varies from 9 to 50 hours between individuals. Amitriptyline is not addictive.

Before taking Amitriptylin 25mg Danapha drug treatment (100 tablets)

How to use

Take oral use.

Dosage

Adults

Normal beginning 75 mg/day, divided 3 times (or a single dose at night). The dose of 150 mg/day may be increased if necessary, with the increased dose is given priority to use in the evening or before going to bed. The sedative effect appears very early, and anti-depression is takes 3-4 days or even 30 days to see.

Maintenance dose is 50 - 100 mg/day. Can take a single dose in the evening or before going to bed. When the drug has adequate effects and the condition of the patient has improved, the minimum dose can be reduced to maintain the effect.

Continue to maintain at least three months to avoid recurrence.

Elderly

The dose should be reduced in these patients to avoid side effects, especially confusing, inciting and lowering posture.

The starting dose is recommended by 10 - 25 mg, 3 times/day, so it should be increased slowly. The dose of 50 mg/day can be used for elderly patients who do not tolerate higher doses. Can divide the dose or only dose in the evening or before going to bed.

Children

Depression: A Amitriptylin 25mg should not be used for children under 12 years old (due to lack of experience).

Teenagers: Initial dose: 10 mg/time, 3 times/day and 20 mg at bedtime. It is necessary to gradually increase the dose, but the dose usually does not exceed 100 mg/day.

Night beams in older children: Dose suggested for children 6 - 10 years old: 10 - 20 mg oral at bedtime; Children over 11 years old: 25 - 50 mg orally before going to bed. The treatment must not last more than 3 months.

Note: The above dose is for reference only. Specific dosage depends on the condition and level of progression of the disease. For a suitable dose, you need to consult a doctor or medical specialist.What to do when using overdose?

mainly treat symptoms and support, including:

Stomach lavage: Use activated carbon in the form of mud many times.

Maintain respiratory function, circulation and body temperature. Scratch by using diazepam, paraldehyde, phenytoin or inhaling anesthetics to control seizures. However, if close to the next dose, skip the forgotten dose and take the next dose at the time as planned. Note that it should not be used double the prescribed dose.

Side Effects

When using Amitriptylin 25mg, you may experience unwanted effects (ADR).

Common, ADR> 1/100

excessive sedation, loss of orientation, sweating, increasing appetite, dizziness, headache;

tachycardia, hitting chest drums, changing electrocardiograms (flat or reversed waves), atrial block, lower blood pressure;

Sexual and impotence reduction;

Nausea, constipation, dry mouth, change taste;

loss of transportation;

Difficult to regulate, blurred vision, and pupils.

Uncommon, 1/1000

Hypertension;

vomiting;

Outdoor, face, tongue edema;

paresthesia, tremor;

Hung feels, mildly, difficult to concentrate, anxiety, insomnia, nightmares;

urination;

glaucoma;

tinnitus.

Rarely ADR

faint, fever, edema, anorexia;

Loss of granulocytes, eosinophilia loves eosin, leukopenia, platelets;

Men's breasts, testicular swelling, increased milk secretion, reducing ADH secretion;

diarrhea, intestinal paralysis, gland inflammation;

Hair loss, urticaria, hemorrhage, sensitivity to light;

jaundice, increased transaminase;

seizures, speech disorders, foreign symptoms;

Illusion (schizophrenia), paranoia (elderly patients), dose reduction.

Instructions on how to handle ADR

When experiencing side effects of amitriptylin 25mg, it is necessary to stop using and notify the doctor or go to the nearest medical facility for timely treatment.

Warnings

Before using Amitriptylin 25mg, you need to read the instructions carefully and refer to the information below.

Contraindications:

Amitriptylin 25mg contraindications in the following cases:

Patients with amitriptylin, antidepressants or any ingredients of the drug;

are using Monoamine oxidase inhibitors or used in the past 14 days;

History of myocardial infarction, arrhythmia, congestive heart failure, coronary artery failure;

People with severe liver failure, porphyrin metabolism;

Patients with heart blocking at any level;

Hung Cam.

Precautions when using

uncontrolled seizure: urinary retention and prostate hypertrophy; impaired liver function; increasing glaucoma of closed angle; cardiovascular disease; Hyperthyroidism or being treated with thyroid drugs.

Patients who have treated with monoamin oxydase inhibitors, must stop taking this drug for at least 14 days, to start treatment with amitriptylin 25mg.

Using 3 -round antidepressants along with anti -cholinergic drugs can increase the anti -cholinergic effect.

The risk of suicide is still in the course of treatment until the disease has improved.

The treatment of depression accompanied by schizophrenia must always be in combination with sedative drugs because 3 -round antidepressants can make the symptoms more severe.

In the patient Hung - depression, increased the risk of occurring and prolonged the revision stage. For epilepsy, it is necessary to treat anti -epilepsy appropriately to compensate for the risk of increasing attacks during treatment.

The ability to drive and operate machinery

The risk of sleep can cause accidents during labor, driving.

Pregnancy

3 -round antidepressants over the placenta into the fetus. Amitriptylin, nortriptylin causes sedation and urination in infants. The rate of reduction of symptoms from a few days to a few weeks depends on the rate of reducing drug concentration in newborns. Therefore, in the last three months of pregnancy, Amitriptylin is only used with strict indications, need to consider the benefits of the mother and the risk of the fetus.

Lactation period

Amitriptylin excreted breast milk with a significant amount of children at the treatment dose. It is necessary to decide to stop breastfeeding or stopping the drug, taking into account the importance of the drug for the mother.

Interactive drug

Interaction between 3 -round antidepressants and monoamine oxidase inhibitors is an interaction with potential risk of death.

Coordinate with phenothiazine to increase the risk of seizures.

Because antidepressants 3 -ring inhibiting liver enzyme, if combined with anticoagulants, there is a risk of increased anticoagulant effect to more than 300%.

Genital hormones, anti -oral anti -oral drugs increase the bioavailability of 3 -round antidepressants.

When using Physostigmin to reverse the effect of 3 -ring anti -depression drugs on the central nervous system (treating, paranoia, coma) can cause heartbustes, impulsive disorders, causing arrhythmia.

With Levodopa, the anti -cholinergic anti -depression effect can cause the stomach to slow down the food slowly, thus reducing Levodopa's bioavailability.

Cimetidine inhibits the metabolism of 3 -round antidepressants, increasing the concentration of these drugs in the blood that can lead to poisoning.

Clonidin, Guanethidin or Guanadrel are reduced the effect of lowering blood pressure when used simultaneously with 3 -round antidepressants.

Concentrated with 3 -round antidepressants and sympathetic drugs that increase the effect on the heart can lead to arrhythmia, tachycardia, severe hypertension, or high fever.

Storage

In a dry place, avoid light, the temperature does not exceed 30 ° C.

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