Amloda 5mg medicine Armephaco treats hypertension, angina (10 blisters x 10 tablets)

Dosage form Box of 10 blisters x 10 tablets
Specifications Amlodipine
Ingredient Armepharco

Ingredient

Composition information	Content
Amlodipine	5mg

Uses

indications

Amloda drugs are indicated in the following cases:

Treatment of hypertension (in patients with metabolic complications such as diabetes). Because the heart frequency is not affected, the post -burden of the heart reduces the heart, along with reducing the need for oxygen and energy to the heart muscle. This reduces the risk of angina. In addition, amlodipine also causes coronary artery dilatation both in ischemic area and the area is provided with normal blood. This vasodilation increases the supply of oxygen for patients with cramped angina (Prinzmetal angina). This reduces nitroglycerin demand and in this way, the risk of nitroglycerin resistance may decrease. The time for anti -angina effect is 24 hours. People with angina can use amlodipine in combination with beta blockers and always use with nitrate (basic treatment of angina).

Mechanism of action

Amlodipin is a derivative of dihydropyridine that has the effect of blocking the flow into the calcium through the cell membrane. Amlodipine prevents calcium channel L depending on the voltage, impact on blood vessel and heart smooth muscles. Amlodipine has anti -hypertension effects by directly relaxing smooth muscles around the peripheral artery and has less effect on myocardial calcium channel.

So the drug does not conduct the atrial transmission in the heart worse and does not adversely affect myocardial force. Amlodipine also works well as reducing kidney blood vessels, thus increasing blood flow in the kidneys and improving kidney function. So the drug can also be used to treat people with heart failure.

Amlodipin has no adverse effects on plasma lipid concentrations or glucose metabolism, so it can be used amlodipine to treat hypertension in people with diabetes. Amlodipine works well when standing, lying as well as sitting and while working. Because amlodipine is slowly acting, there is little risk of acute or anti -tachycardia.

Pharmacokinetics

absorption

After taking treatment doses, Amlodipin is well absorbed with peak concentration in plasma reaching about 6 to 12 hours after drinking. Absolute bioavailability, estimated at 64% - 80%. The distribution volume is about 21 l/kg. Amlodipine absorption is not affected by food.

In vitro studies show that about 97.5% amlodipine in the circulation is attached to plasma proteins.

Metabolism/excretion

Amlodipin's plasma semi -discharged time ranges from 35 to 50 hours and is suitable for daily dosage daily. The concentration of the constant state in plasma is achieved after 7 to 8 days of continuous medication. Amlodipine is metabolized in liver into liver into non -active metabolites, with 10% of the original substance and 60% of the metabolic substance eliminated through the urine.

Used in the elderly

Time to reach the peak concentration of amlodipine plasma is the same between the elderly and young people. However, Amlodipine's clearance tends to decrease with an increase, the area under the curve (AUC) and the selling time in elderly patients. Area under the curve and time, semi -discharged in patients with congested heart failure (CHF) also increased as expected in the age group.

Before taking Amloda 5mg medicine Armephaco treats hypertension, angina (10 blisters x 10 tablets)

How to use

Take oral use.

Dosage

To treat hypertension and angina: The dose must be suitable for each patient. In general, starting with a normal dose is 5mg, 1 time for 24 hours. The dose can increase to 10 mg for 1 time in 1 day.

If the effect does not work after 4 weeks of treatment may increase the dose. No need to adjust the dose when combining thiazid diuretics.

Note: The above dose is for reference only. Specific dosage depends on the condition and level of progression of the disease. For a suitable dose, you need to consult a doctor or medical specialist.What to do when using overdose?

No report.

In an emergency, call the 115 emergency center immediately or go to the nearest local health station.

What to do when you forget a dose? However, if close to the next dose, skip the forgotten dose and take the next dose at the time as planned. Note that it should not be used double the prescribed dose.

Side Effects

When using Amloda, you may experience unwanted effects (ADR).

amlodipin is well tolerated. In controlled clinical trials in patients with angina or high blood pressure, the side effects are common at a mild and moderate level such as headache, edema, fatigue, nausea, dizziness, and drums.

Very rarely itching, weakness, and cramps.

Instructions on how to handle ADR

When experiencing side effects of the drug, it is necessary to stop using and notify the doctor or go to the nearest medical facility for timely treatment.

Warnings

Before using the drug you need to read the instructions carefully and refer to the information below.

contraindicated

AMLODA drugs contraindicated in the following cases:

Not used for people who have not been treated stably.

Hypersensitivity to dihydropyridin.

Pregnant women in the first three -month pregnancy of pregnancy.

Be cautious when using

with people who reduce liver function, artery stenosis, heart failure after acute myocardial infarction.

The ability to drive and operate machinery

The drug does not affect the ability to drive and operate machinery.

Pregnancy

Calcium channel blockers can inhibit early uterine contractions. However, the drug has no adverse effects on the birth process. The risk of oxygen deficiency must be taken into account if causing hypotension in the mother, because there is a risk of reducing placental perfusion. This is a common risk when using hypertension medications, they can change the blood flow due to peripheral vasodilation.

In experimental animals, calcium channel blockers can cause teratogenic bone deformities. Therefore, avoid using amlodipine for pregnant women, especially in the first 3 months of pregnancy.

Breastfeeding period

There is no data to evaluate the accumulation of Amlodipin in breast milk.

Interactive drug

Anesthesia increases the anti -hypertension effect of amlodipine and can make blood pressure more sharply.

Lithi: When used with amlodipine, it can cause nerves, nausea, vomiting, diarrhea.

Non -steroid anti -inflammatory drugs, especially indomethacin, can reduce the anti -hypertension effect of amlodipine due to prostaglandin synthesis inhibitors and/or keep sodium and translate.

High -linked drugs with protein (such as Coumarin, Hytantoin ...) must be used carefully with amlodipin, because amlodipine is also highly linked to protein, the concentration of the above drugs is free (non -linked), can change in serum.

Storage

In a dry place, avoid light, temperature below 30 ° C.

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