Amlodac 5 cadila medicine for hypertension, angina (10 blisters x 10 tablets)
Dosage form Box of 10 blisters x 10 tablets
Specifications Amlodipine
Ingredient High blood pressure, angina
Ingredient
| Composition information | Content |
| Amlodipine | 5mg |
Uses
indications
Amlodac 5 drugs are indicated in the following cases:
Amlodipine has anti -hypertension effects by directly relaxing smooth muscles around the peripheral artery and has less effect on myocardial calcium channel.
So the drug does not conduct the atrial transmission in the heart worse and does not adversely affect the muscle contraction force. Amlodipine also works well as reducing kidney blood vessels, thus increasing blood flow in the kidneys and improving kidney function.
So the drug can also be used to treat people with heart failure.
Amlodipin has no adverse effects on plasma lipid concentrations or glucose metabolism, so it can be used amlodipine to treat hypertension in people with diabetes.
However, there are no long -term clinical trials to prove that Amlodipine has the effect of reducing death.
In many countries, the standard treatment to protect patients with hypertension from stroke and death is still beta and diuretics, these drugs are first selected for treatment.
However, Amlodipin can be used in combination with beta blockers along with thiazid or diuretics and with angiotensin conversion enzyme inhibitors.
Amlodipin works well when standing, lying as well as sitting and while working. Because amlodipine is slowly acting, there is less risk of acute or reflective hypotension.
Anti -angina effect: Amlodipin relaxes peripheral arteries, thus reducing the entire obstacle in the peripheral circuit (after -burden).
Because the heart frequency is not affected, the posterior burden of the heart reduction, along with reducing the need for oxygen and energy to the heart muscle. This reduces the risk of angina.
In addition, amlodipine also causes coronary artery dilatation both in ischemic area and the area is provided with normal blood. This vasodilation increases the supply of oxygen for patients with cramped angina (Prinzmetal angina). This reduces nitroglycerin demand and in this way, the risk of nitroglycerin resistance may decrease.Time for anti -angina effect is 24 hours. People with angina can use amlodipine in combination with beta blockers and always use with nitrate (basic treatment of angina).
pharmacokinetics
absorption:
After taking the treatment dose, Amlodipin is well absorbed with peak concentration in plasma reaching about 6 to 12 hours after drinking. Absolute bioavailability is estimated at 64% - 80%.
The distribution volume is 21 kg. Amlodipine's absorption is not affected by food.
Metabolism, elimination:
Amlodipin's plasma semi -discharged time is about 35 to 50 hours and is suitable for the dosage once a day.
The concentration in the state of plasma is achieved after 7 to 8 days of continuous drug use.
amlodipine is metabolized largely in the liver into non -active metabolites. 10% of the initial substance and 60% of metabolic substances are eliminated in the urine.
Before taking Amlodac 5 cadila medicine for hypertension, angina (10 blisters x 10 tablets)
How to use
AMLODAC 5 drugs for oral.
Amlodipin Besylat can be taken for or away from meals, food does not affect the absorption of drugs.
Should take medicine at the same time of the day to avoid forgetting the medicine.
Dosage
Dosage in case of hypertension treatment:
Note: The dose is for reference only. Specific dosage depends on the condition and level of progression of the disease. For a suitable dose, you need to consult a doctor or medical specialist.What to do when overdose?
Use 30 mg of amlodipine for children 1 and a half years only causing average poisoning.
In case of an overdose with calcium blockers, the general treatment is as follows:
Monitor cardiovascular disease with electrocardiograms and treat symptoms of effects on cardiovascular effects along with gastric lavage and active carbon drinking. If necessary, electrolytes must be adjusted.
Cases of heartbeat and heart block, must be injected with atropin 0.5 - 1 mg into the veins for adults (for children, intravenously 20 - 50 mg/1kg of weight). If necessary, repeat.
20 ml intravenous drip injection of calcium gluconate (9 mg/ml) for 5 minutes for adults, adding isoprenalin 0.05 -0.1 mg/kg/minute or adrenalin 0.05 -0.3 mg/min/minute or dopamine 4-5 μg/kg/minute.
For patients with reduced circulatory volume, 0.9%sodium chloride solution is required. When needed, pacemaker must be placed.
In case of serious hypotension, intravenously, 0.9% adrenalin sodium chloride solution. If not effective, use isoprenalin in combination with amrinone. Symptomatic treatment.
What to do when forgetting 1 dose?
Not recorded.
Side Effects
When using Amlodac 5 drugs, you may experience unwanted effects (ADR).
Common, ADR> 1/100
Systemic: edema, headache, dizziness, blushing face and feeling hot, fatigue, weakness.
The circulatory system: Brushing the chest.
Central nervous system: cramps.
Digestive system: Nausea, abdominal pain, indigestion.
Respiratory system: Difficulty.
rarely, 1/1000
Excessive blood pressure system, excessive hypotension, tachycardia, chest pain.
Skin: Outdoor, itching.
muscle, joints: muscle pain, joint pain.
Mental: Sleep disorder.
Instructions on how to handle ADR
When experiencing side effects of the drug, it is necessary to stop using and notify the doctor or go to the nearest medical facility for timely treatment.
Warnings
Before using the drug you need to read the instructions carefully and refer to the information below.
Contraindicated
Amlodac 5 contraindications in the following cases:
amlodipine is contraindicated in patients with a history of hypersensitivity to dihydropyridine, amlodipine, or any ingredients of this drug.
Heart failure, shock (including cardiac shock), unstable angina, hypotension, congestion of left ventricle (such as severe aortic valve stenosis), unstable hemodynamic heart failure after acute myocardial infarction.
breastfeeding women.
Children under 6 years old.
Caution when used
The safety and effectiveness of amlodipine on the hypertension has not been established.
Used in patients with heart failure:
Patients with heart failure should be treated carefully.
In a long -term study of a placebo, amlodipine in patients with heart failure due to anemia (NYHA level III and VI), Amlodipine is reported to be related to an increase in pulmonary edema ratio.
Calcium channel blockers, including amlodipine, should be used carefully in patients with congestive heart failure, as they can increase the risk of future cardiovascular complications and death rates.
Use in patients with impaired liver function:
Amlodipine waste time is prolonged and higher AUC value in patients with impaired liver function, recommended dosage has not been established.
amlodipine should therefore be started at the lowest dose and need to be used cautiously, both in the initial treatment and when increasing the dose. Slowly detecting and careful monitoring may be required in patients with severe liver failure.
Used for patients with renal failure:
Amlodipine plasma changes are not related to renal failure. Amlodipin can be used for these patients in normal doses. Amlodipin cannot be appraised.
Used for the elderly:
Amlodipin used in the same dose for the elderly and young people are equally tolerated. Therefore, the usual dosage can also be used for the elderly, but need special care if the dose increases.
Use for children:
Not known the effectiveness of amlodipine on blood pressure in patients under 6 years old.
The ability to drive and operate machinery
amlodipine can cause unwanted effects such as headache, dizziness, fatigue, ... Therefore, be careful when used for drivers or operating machinery.
pregnancy
Amlodipin's safety when used for pregnant women has not been established. In animal studies, reproductive toxicity has been observed in high doses.
Use during pregnancy is only recommended when there is no safer alternative and when the disease is a greater risk for the mother and the fetus.
The period of breastfeeding
It is not known whether amlodipine will be excreted through breast milk. A decision on whether or not to continue breastfeeding or continuing/stopping treatment with amlodipine should be performed based on the risk of breastfeeding and the benefits of treatment for the mother.
Interactive drug
The effect of other drug products on amlodipin:
CYP3A4 inhibitors:
Simultaneous use amlodipine with strong or medium CYP3A4 inhibitors (protease inhibitors, antifungal drugs azol, macrolid such as erythromycin or clarithromycin, verapamil or diltiazem) can lead to significant increase in contact with amlodipine, leading to an increased risk of lowering blood pressure.
Pharmacokinetic changes may be more pronounced in the elderly. Clinical monitoring and dose adjustment may be required.
CYP3A4 induction drugs:
There is no available data related to the effects of CYP3A4 induction drugs on Amlodipin.
Concomitance the use of CYP3A4 induction drugs (for example, rifampicin, plants) may reduce the concentration of amlodipine. Amlodipin should be cautious when used with drugs causing CYP3A4.
Take amlodipine with grapefruit or grapefruit juice is not recommended by bioavailability may increase in some patients leading to increased hypotension effect.
dantrollen (infusion):
In animals, death vibration and cardiovascular collapse are observed with hyperkalemia after taking Verapamil and Dantrolene intravenously.
Due to the risk of hyperkalemia, it is recommended that not using the same calcium channel blockers like amlodipin to avoid patients susceptible to malignant body hyperthermia and in managing malignant body temperature.
Effect of amlodipine on other drugs:
Amlodipin co -acting effects on similarly used with other anti -blood pressure drugs.
tacrolimus:
There is a risk of increasing blood concentration of tacrolimus when treated in combination with amlodipine but the pharmacokinetic mechanism of this interaction is not fully understood.
To avoid tacrolimus poisoning, when concurrent use amlodipine for patients treated with tacrolimus should require monitoring Tacrolimus concentration in the blood and adjust the dose of tacrolimus when appropriate.
cyclosporin:
There is no drug interaction studies have been conducted with cyclosporin and amlodipine in healthy volunteers or other patients except for kidney transplant patients, where the base concentration of cyclosporin may change (average 0% - 40%) has been observed.
It is necessary to consider monitoring cyclosporin levels in kidney transplant patients when taking amlodipine and reducing cyclosporin dose should be done when necessary.
simvastatin:
10 mg of amlodipin, 80 mg of simvastatin leads to an increase in 77% of the effect of simvastatin compared to using simvastatin alone.
That is the recommendation to limit the dosage of simvastatin 20 mg daily in patients using amlodipine.
In clinical interactive studies, Amlodipin does not affect the pharmacokinetics of Atorvastatin, Digoxin or Warfarin.
Storage
Storage below 30 ° C. Avoid light.
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