Amlodipin 5mg medicine Vidipha treats hypertension, angina (10 blisters x 10 tablets)

Dosage form Box of 10 blisters x 10 tablets
Specifications Amlodipine
Ingredient High blood pressure, angina

Ingredient

Composition information	Content
Amlodipine	5mg

Uses

indicated

amlodipin 5mg indicated in the following cases:

Treatment of hypertension (patients have metabolic complications such as diabetes). Amlodipin prevents calcium -type calcium channels depending on the voltage, impact on blood vessel and heart smooth muscles.

Amlodipine has anti -hypertension effects by directly relaxing smooth muscles around the peripheral artery and has less effect on the heart muscle calcium channel. Therefore, the drug does not conduct the atrial transmission in the heart worse and does not affect myocardial force.

Amlodipin also works well, which is to reduce kidney blood vessel resistance, thus increasing blood flow in the kidneys and improving kidney function. So the drug can also be used to treat people with heart failure.

Amlodipin has no adverse effects on plasma lipid concentrations or glucose metabolism, so it can be used amlodipine to treat hypertension in people with diabetes. Amlodipine works well when standing, lying as well as wandering and while working. Because amlodipine is slowly acting, there is less risk of acute or reflective hypotension.

Anti -angina effect: Amlodipin relaxes peripheral arteries, thus reducing the entire obstacle in the peripheral circuit (posterior).

Because the heart frequency is not affected, the posterior burden of the heart reduction, along with reducing the need for oxygen and energy to the heart muscle. This reduces the risk of angina. In addition, Amlodipine also causes coronary artery dilatation both in ischemic area and the area is provided with normal blood. This vasodilation increases the supply of oxygen for patients with cramped angina (Prinzmetal angina). This reduces nitroglycerin demand and in this way, the risk of nitroglycerin resistance may decrease.

Time for anti -angina effect is 24 hours. People with angina can use amlodipine in combination with beta blockers and always use with nitrate (basic treatment of angina).

pharmacokinetics

absorption, distribution, attached to plasma proteins

After taking the treatment dose, Amlodipin is well absorbed, reaching the blood peak concentration of 6 -12 hours after drinking. Absolute bioavailability has been estimated at 64 and 80%. The distribution volume is about 21 I/kg.

In vitro studies show that about 97.5% of amlodipine circulating with plasma proteins.

AMLodipine's biological available is not affected by food.

Biological change elimination

Eliminating the last selling time is about 35-50 hours and is suitable for the dosage once a day. Amlodipine is widely metabolized in the liver into metabolic substances that do not work with 10% of the original compounds and 60% of the metabolites excreted in the urine.

liver failure

Clinical data is related to the use ofamlodipine in patients with liver failure. Patients with liver failure reduces the clearance of amlodipine, resulting in a longer selling time and an increase in AUC by 40-60%.

used in children

A pharmacokinetic study was conducted in 74 children with hypertension aged 1-17 (with 34 patients aged 6 to 12 years old and 28 patients aged 13 to 17 years old) taking Amlodipine between 1.25 and 20mg for each or twice a day. In children 6 to 12 years old and in adolescents 13-17 years old orally (Clif) are 22.5 and 27.4 l/hour respectively in men and 16.4 and 21.3 l/hour respectively in women.

Major changes in the use of drugs among individuals have been observed. Report data in children under 6 years old is limited.

used in the elderly

Time to achieve amlodipine plasma peak concentrations in the elderly is similar to younger people. Amlodipine clearance tends to decrease, resulting in increasing the scope and the time of selling waste in elderly patients. ACu increased a few waste time in patients with congestive heart failure has been predicted for studies according to patient age groups.

Before taking Amlodipin 5mg medicine Vidipha treats hypertension, angina (10 blisters x 10 tablets)

How to use

amlodipin 5mg hard capsules for oral.

Dosage

To treat hypertension and angina, the dose must be suitable for each patient. In general, starting with a normal dose is 5mg, 1 time for 24 hours. The dose can increase to 10mg for 1 time in 1 day.

If the effect does not work after 4 weeks of treatment may increase the dose. No need to adjust the dose when combining thiazid diuretics.

Children with hypertension from 6 years old to 17 years old: The dose of hypotension initially suggested for children aged 6-17 years old at 2.5mg once a day, increasing the dose up to 5mg once a day if the target of lowering blood pressure is not achieved after 4 weeks. The dose exceeds 5mg daily has not been studied in children (see the pharmacokinetic part and pharmacokinetics).

The effect of amlodipine on patients' blood pressure is not more than 6 years old.

used in elderly amlodipin is used in dosage in elderly patients similar to younger people, the drug is well tolerated. Therefore, the usual dosage regimen is recommended, but should be cautious when increasing the dose (see caution and pharmacokinetics).

Patients with liver failure:

Dosage for suggestions has not been established for patients with mild to moderate liver failure, thus carefully selecting the dose and should start the lowest end dose of the sequence (see caution and pharmacokinetics).

Amlodipin's pharmacokinetics have not been studied in severe liver failure. Amlodipine should be started at the lowest dose and increase the dose slowly in patients with severe liver failure.

Patients with renal impairment: The change of amlodipine concentration in plasma is not correlated with the degree of renal failure, so the normal dose is proposed. Amlodipine is not removed when separating.

What do

do when overdose?The existing data shows that amlodipine overdose can lead to excessive peripheral vasodilation and may have a tachycardia reflection. Clearly and certainly prolong the hypotension and including shock, leading to a death result.

Use 30mg of amlodipine for children 1 and a half years only causing "average" poisoning.

In case of overdose with calcium blockers, the general treatment is as follows:

Monitor cardiovascular disease with electrocardiograms and treat symptoms of effects on cardiovascular effects along with gastric lavage and active carbon drinking. If necessary, electrolytes must be adjusted. In case of bradycardia and heart heart, atropin must be injected with an atropin into the vein for adults (for children, intravenously 20-50 micrograms/1kg of weight).

If needed, repeat injection. Inject the intravenous drop of 20ml of calcium gluconate solution (9 mg/ml) for 5 minutes for the large one; Add isoprenalin 0.05 -0.1 micrograms/kg/minute or adrenalin 0.05 -0.3 micrograms/kg/minute or dopamine 4-5 micrograms/kg/min.

For patients with reduced circulatory volume, 0.9%sodium chloride solution is required. When needed, pacemaker must be placed.

In case of severe hypotension, intravenously 0.9%sodium chloride solution, adrenalin. If not effective, use isoprenalin in combination with amrinone. Symptomatic treatment.

Note: The gastric lavage is only effective within 6 hours within an hour after taking the medication and dialysis does not work (due to the strong drug associated with plasma proteins).

What to do when you forget the dose? However, if close to the next dose, skip the forgotten dose and take the next dose at the time as planned. Note that it should not be used double the prescribed dose.

Side Effects

When using Amlodipin, you may experience unwanted effects (ADR).

The most common side effect of Amlodipin is ankle edema, from light to medium related to the dose.

Common:

Systemic: edema, headache, dizziness, blushing face and feeling hot, fatigue, weakness.

Circulation: Brushing the chest.

Central nerve: cramps, headaches, dizziness, sleeping.

On the heart: flushing.

Digestive: Nausea, abdominal pain, indigestion.

Respiratory: Difficulty breathing.

Uncommon:

Circulation: excessive hypotension, tachycardia, chest pain.

Skin: Outdoor, itching.

muscle, bone: muscle pain, joint pain.

Mental: Sleep disorder.

rare:

Circulation: extra mind.

Gastrointestinal: Increasing productivity.

Skin: urticaria.

Liver: Increased liver enzyme (transaminase, phosphatase test, lactate dehydrogenase).

Metabolism: increased blood glucose.

Mental: Confusion.

Diverse immunity.

In addition:

On the liver: dermatitis, jaundice.

On gastrointestinal: pancreatitis, gastritis.

Immunology: Evala, urticaria, flaking dermatitis, Stevens-Johnson syndrome, rhymes, light sensitivity.

urinary tract: urination disorders, night urination, increase the number of urination.

Reproduction: Big breast, physiological disorders, impotence.

weight gain or weight loss.

Note: Notify the doctor the unwanted effects encountered when using the drug.

Warnings

Before using the drug you need to read the instructions carefully and refer to the information below.

contraindicated

amlodipine 5mg contraindicated in the following cases:

Not used for people who have not been treated stably.

Be cautious when using

should be very careful when using drugs for humans with people who reduce liver function, aortic stenosis, cardiac failure after acute myocardial infarction.

The ability to drive and operate machinery

The drug can affect the ability to drive from light to medium.

Pregnant and lactating women

Women during pregnancy:

Calcium channel blockers can inhibit early uterine contractions. However, the drug has no disadvantage for the birth process.

Tclecy of the risk of lack of oxygen for the fetus if causing hypotension in the mother, because of the risk of reducing the placenta perfusion. This is a common risk when using hypertension medications, they can change the blood flow due to peripheral vasodilation.

In experimental animals, calcium channel blockers can cause teratogenic bone deformities. Therefore, avoid using amlodipine for pregnant women, especially in the first 3 months of pregnancy.

Lactating women: The drug is distributed in breast milk.

Interactive drug

Anesthesia increases the anti -hypertension effect of amlodipine and can make blood pressure more sharply.

Lithi: When used with amlodipine, it can cause nerves, nausea, vomiting, diarrhea.

Non -steroid anti -inflammatory drugs, especially indomethacin, can reduce the anti -hypertension effect of amlodipine due to prostaglandin synthesis inhibitors and/or keep sodium and translate.

High -linked drugs with protein (such as Coumarin, Hytantoin, ...) must be used carefully with amlodipin, because amlodipine is also highly linked to protein, the concentration of the above drugs is free (not linked), can change in serum.

CYP3A4 inhibitors: simultaneous use of amlodipine with strong or medium inhibitors CYP3A4 (Protease inhibitors, antifungal drugs azol, macrolid such as erythromycin or clarithromycin, verapamil or diltiazem) can lead to significantly increased absorption of amlodipine, leading to increased hemorrhage risk. The clinical changes of these kinetic changes manifest on the elderly. Clinical monitoring and dose adjustment if necessary.

CYP3A4 induction drugs: There is no data related to the effect of the CYP3A4 induction drug on Amlodipin. The simultaneous use of CYP3A4 induction drugs (for example, Rifampicin, Hypericum Perforatum) can reduce Amlodipine levels.

amlodipin carefully used when used with induction drugs.

Storage

Leave a cool place, avoid light, temperature below 30⁰C.

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