Amlodipin 5mg medicine Vidipha treats hypertension, angina (3 blisters x 10 tablets)

Dosage form Box of 3 blisters x 10 tablets
Specifications Amlodipine
Ingredient High blood pressure, angina

Ingredient

Composition information	Content
Amlodipine	5mg

Uses

indications

Amlodipine 5 mg vidipha is indicated in the following cases:

Treatment of hypertension (in patients with metabolic complications such as diabetes).

Preventive treatment in patients with stable angina. Amlodipine prevents calcium channel L depending on the voltage, impact on blood vessel and heart smooth muscles.

Amlodipine has anti -hypertension effects by directly relaxing smooth muscles around the peripheral artery and has less effect on the heart muscle calcium channel. Therefore, the drug does not conduct the atrial transmission in the heart worse and does not affect myocardial force. Amlodipine also works well as reducing kidney blood vessels, thus increasing blood flow in the kidneys and improving kidney function. Therefore, the drug can also be used to treat people with heart failure.

Amlodipin has no adverse effects on plasma lipid concentrations or glucose metabolism, so it can be used amlodipine to treat hypertension in people with diabetes. Amlodipine works well when standing, lying as well as sitting and while working. Because amlodipine is slowly acting, there is less risk of acute hypotension or reflective tachycardia.

Anti -angina effect: Amlodipin relaxes peripheral arteries, thus reducing the entire obstacle in the peripheral circuit (after the burden of the burden). Because the heart frequency is not affected, the post -burden of the heart reduces the heart, along with reducing the need for oxygen and energy to the heart muscle. This reduces the risk of angina.

In addition, amlodipine also causes coronary artery dilatation both in ischemic area and the area is provided with normal blood. This vasodilation increases the supply of oxygen for patients with cramped angina (Prinzmetal angina). This reduces nitroglycerin demand and in this way, the risk of nitroglycerin resistance may decrease. The time for anti -angina effect is 24 hours. People with angina can use amlodipine in combination with beta blockers and always use with nitrate (basic treatment of angina).

pharmacokinetics

absorption, distribution, plasma protein

After taking the treatment dose, Amlodipin is well absorbed, reaching the blood peak concentration from 6 to 12 hours after drinking. Absolute bioavailability has been estimated at 64 and 80%. The distribution volume is about 21 l/kg. In vitro studies show that about 97.5% of amlodipine circulating with plasma proteins.

AMLodipin's biological comfort is not affected by food.

Biological/Elimination Change

The elimination of the last selling time is about 35 - 50 hours and is suitable for the dosage once a day. Amlodipine is widely metabolized in the liver into metabolic substances that do not work with 10% of the original compounds and 60% of the metabolites excreted in the urine.

Hepatic failure

Clinical data related to the use of amlodipine in patients with liver failure is very limited. Patients with liver failure reduces the clearance of amlodipine, resulting in a longer selling time and an increase in AUC by 40 - 60%.

Use in children

A pharmacokinetic study was conducted in 74 children with hypertension ages 1-17 (with 34 patients aged 6 to 12 years old and 28 patients aged 18 to 17 years old) taking Amlodipine between 1.25 and 20 mg for each or twice a day. In children 6 to 12 years old and in teenagers 13-17 years old orally (Cl/F) are 22.5 and 27.4 l/hour respectively in men and 16.4 and 21.3 l/hour respectively in women. Major changes in the use of drugs between individuals have been observed. Report data in children under 6 years old is limited.

Used in the elderly

Time to achieve amlodipine plasma peak concentrations in the elderly is similar to younger people. Amlodipine clearance tends to decrease, resulting in an increase in AUC and the time of selling emissions in elderly patients. Increasing AUC and the time to sell discharged in patients with congestive heart failure have been predicted for studies according to patient age groups.

Before taking Amlodipin 5mg medicine Vidipha treats hypertension, angina (3 blisters x 10 tablets)

How to use

oral medication.

Dosage

To treat hypertension and angina, the dose must be suitable for each patient. In general, the beginning with a normal dose is 5 mg, 1 time for 24 hours. The dose may increase to 10 mg for 1 time in 1 day.

If the effect does not work after 4 weeks of treatment may increase the dose. There is no need to adjust the dose when combining thiazid diuretics.

Children with high blood pressure from 6 years old to 17 years old

The starting dose of blood pressure started for children aged 6 - 17 years old is 2.5 mg once a day, an increase of the dose up to 5 mg once a day if the target of lowering blood pressure is not achieved after 4 weeks. The dose exceeds 5 mg daily has not been studied in pediatric patients (see the pharmacokinetic part and pharmacokinetics). The effectiveness of amlodipine on the blood pressure of a patient is less than 6 years old is not known.

Used in the elderly

Amlodipin is used in dosage in elderly patients similar to younger people, the drug is well tolerated. Therefore, the normal dosage regimen is recommended, but should be cautious when increasing the dose.

Patients with liver failure

The proposed dose has not been established for patients with mild to moderate liver failure, so it is necessary to be careful to choose the dose and should start the lowest last dose of the dose sequence. Amlodipine pharmacokinetics have not been studied in severe liver failure. Amlodipine should be started at the lowest dose and increase the dose slowly in patients with severe liver failure.

Patients with renal failure

The change of amlodipine concentration in plasma is not correlated with the degree of renal failure, so the normal dose is proposed. Amlodipine is not removed when separating.

Note: The above dose is for reference only. Specific dosage depends on the condition and level of progression of the disease. For a suitable dose, you need to consult a doctor or medical specialist.What to do when overdose?

Amlodipine poisoning is very rare.

The existing data shows that amlodipine overdose can lead to excessive peripheral vasodilation and may have a tachycardia reflection. Clearly and certainly prolonging the hypotension and including shock, leading to a reported result.

Use 30 mg of amlodipine for children 1 and a half years only causing "average" poisoning.

In case of overdose with calcium blockers, the general treatment is as follows:

Heart monitoring with electrocardiograms and symptomatic treatment of the effects on the cardiovascular effect with stomach and drinking carbon. If necessary, electrolytes must be adjusted. In case of bradycardia and heart heart, atropine injection must be injected 0.5 - 1 mg into the veins for adults (for children, intravenously 20-50 micrograms/1kg of weight). If necessary, repeat injection. 20 ml of Calcium Gluconate (9 mg/ml) for 5 minutes for adults, add isoprenalin 0.05 - 0.1 micrograms/kg/minute or adrenalin 0.05 - 0.3 microgram/kg/minute or dopamine 4 - 5 microgram/kg/minute.

For patients, the circulatory volume reduces the transmission of 0.9%sodium chloride solution. When needed, pacemaker must be placed.

In case of serious hypotension, intravenously 0.9%sodium chloride solution, adrenalin. If not effective, use isoprenalin in combination with amrinone. Symptomatic treatment.

Note: The gastric lavage is only effective within the first 6 hours (preferably within an hour) after taking the medication and dialysis does not work (due to the strong associated with plasma protein).

In an emergency, call the 115 emergency center immediately or go to the nearest local health station.

What to do when you forget a dose? However, if close to the next dose, skip the forgotten dose and take the next dose at the time as planned. Do not drink twice as prescribed.

Side Effects

When using amlodipine 5 mg vidipha, you may experience unwanted effects (ADR).

The most common side effect of Amlodipin is ankle edema, from light to medium related to the dose.

Common

The whole body: edema, headache, dizziness, blushing and feeling of heat, fatigue, weakness.

Circulation: Brush the chest drum.

Central nervous system: cramps, headaches, dizziness, drowsiness.

On the heart: flush.

digest: Nausea, abdominal pain, indigestion.

Respiratory: Difficulty breathing.

Less

Excessive blood pressure, tachycardia, chest pain.

Skin: Ban, itching.

muscle, bone: muscle pain, joint pain.

Mental: Sleep disorders.

Rare

Circulation: extra mind.

digestion: Increased productivity. skin: urticaria.

Liver: Increased liver enzyme (transaminase, alkaline phosphatase, lactat dehydrogenase).

Metabolic: Hyperglycestation.

Mental: Confusion.

Diverse Hong Ban.

In addition

On the liver: Dermatitis, jaundice.

On gastrointestinal: pancreatitis, gastritis.

Immunology: Evala, urticaria, peeling dermatitis, Stevens - Johnson syndrome, Quincke edema, light sensitivity.

urinary tract: urination disorders, night urination, increase the number of urination.

Reproduction: big breast, physiological disorders, impotence.

weight gain or weight loss.

Instructions on how to handle ADR

When experiencing side effects of the drug, it is necessary to stop using and notify the doctor or go to the nearest medical facility for timely treatment.

Warnings

Before using the drug you need to read the instructions carefully and refer to the information below.

Contraindicated

Amlodipine 5 mg Vidipha is contraindicated in the following cases:

Not used for people who have not been treated stably.

Hypersensitivity to dihydropyridine.

Hypoglycemia, shock (including cardiac shock), congestion of left ventricular drainage (eg aortic stenosis).

Be cautious when using

with people who reduce liver function, artery stenosis, heart failure after acute myocardial infarction.

The ability to drive and operate machinery

The drug can affect the ability to drive from light to medium.

Pregnancy

Calcium channel blockers can inhibit early uterine contractions. However, the drug has no adverse effects on the birth process. The risk of oxygen deficiency must be taken into account if causing hypotension in the mother, because there is a risk of reducing placental perfusion. This is a common risk when using drugs to treat hypertension, they can change blood flow due to peripheral vasodilation.

In experimental animals, calcium channel blockers can cause teratogenic bone deformities. Therefore, avoid using amlodipine for pregnant women, especially in the first 3 months of pregnancy.

Breastfeeding period

drugs distributed in breast milk.

Interactive drug

Anesthesia increases the anti -hypertension effect of amlodipine and can make blood pressure more sharply.

Lithi: When used with amlodipine, it can cause nerves, nausea, vomiting, diarrhea.

Non -steroid anti -inflammatory drugs, especially indomethacin, can reduce the anti -hypertension effect of amlodipine due to prostaglandin synthesis inhibitors and/or hold sodium and fluid.

High -linked drugs with protein (such as Coumarin, Hytantoin, ..) must be used to be careful with amlodipin, because amlodipine is also highly linked to protein, the concentration of the above drugs is free (not linked), can change in serum.

CYP3A4 inhibitors: simultaneous use of amlodipine with strong or medium inhibitors CYP3A4 (Protease inhibitors, antifungal drugs azol, macrolid such as erythromycin or clarithromycin, verapamil or diltiazem) can lead to significantly increased absorption of amlodipine, leading to increased hemorrhage risk. The clinical changes of these kinetic changes manifest on the elderly. Clinical monitoring and dose adjustment if necessary.

CYP3A4 induction drugs: There is no data related to the effect of the CYP3A4 induction drug on Amlodipin. The simultaneous use of CYP3A4 induction drugs (for example, Rifampicin, Hypericum Perforatum) may reduce Amlodipine levels. Amlodipin should be cautious when used with induction drugs.

Storage

In a dry place, the temperature does not exceed 30 ° C, avoiding light.

Expiry date: 36 months from the date of manufacture. Do not use overdue drugs stated on the packaging.

This drug is only used by a doctor.

Do not use the drug if:

The tablet is discolored, dented, cracked.

blisters are torn.

Discontinue medication immediately and notify the doctor when experiencing allergies.

to be out of reach of children.

Read the instructions carefully before use. If you need more information, please consult a doctor.

Manufacturer: Central Pharmaceutical Joint Stock Company Vidipha.

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