Amlodipin Stada 5mg treatment for hypertension, angina (3 blisters x 10 tablets)

Dosage form Box of 3 blisters x 10 tablets
Specifications Amlodipine
Ingredient Stada

Ingredient

Composition information	Content
Amlodipine	5mg

Uses

Indications

Amlodipin Stada 5mg is indicated in the following cases:

Use single or combined with other anti -hypertension drugs to treat hypertension .

Prinzmetal variable angina and lumbarity chronic stability. The drug can be used alone or in combination with other anti -angina drugs.

Pharmacy

amlodipin is a calcium antagonistic drug belonging to the dihydropyridine group (calcium ion antagonism or slow channel blockers), inhibiting calcium flow through cell membranes into the cellular muscle into blood vessels and heart muscle. The process of vascular muscle and blood vessel muscles depends on the movement of extracellular calcium ions into these cells through specialized ion channels. Amlodipine selectively inhibits calcium flow through cell membranes, with the effects on smooth vascular muscle cells on myocardial cell. Amlodipine is a peripheral artery, directly acting on blood vessel smooth muscles, causing reduced peripheral vascular resistance and reducing blood pressure.

pharmacokinetics

amlodipin absorb good through oral route with peak concentration in blood achieved after 6 - 12 hours. Birth changes but usually in the range of 60 - 65%. About 97.5% amlodipine is attached to plasma proteins. The final sale time lasts 35 - 50 hours and stable plasma concentrations achieved after 7-8 days of medication. Amlodipine is metabolized mostly in the liver, its metabolites are mainly eliminated in the urine with less than 10% of the dosage in constant form. Amlodipine is not excluded by the method of appraisal.

Before taking Amlodipin Stada 5mg treatment for hypertension, angina (3 blisters x 10 tablets)

How to use

Take the tablet with a glass of water. Regardless of meals.

Dosage

Hypertension

Adults

The usual starting dose of amlodipine is 2.5 - 5mg x 1 time/ day. The elderly and thin people should start the starting dose of 2.5mg x 1 time/day. The next dose should be adjusted depending on the blood pressure response and patient tolerance, usually not more than 10mg x 1 time/day. The usual maintenance dose to treat hypertension in adults is 5 - 10mg x 1 time/day.

Children 6 years of age and older

The effective use of amlodipine is 2.5 - 5mg x 1 time/day.

angina

To treat Prinzmetal variation or chronic stable angina, the dose commonly used for adults is 5 - 10mg x 1 time/day.

Old people

Should take low doses, 5mg x 1 time/day. The maintenance dose is 10mg daily.

Note: The above dose is for reference only. Specific dosage depends on the condition and level of progression of the disease. For a suitable dose, you need to consult a doctor or medical specialist.

What to do when overdose? Overdose can cause excessive peripheral vessels with symptoms Hypotension clear and capable of causing fast heart due to reflexes.
If serious overdose occurs, it is necessary to monitor the activity of the heart and the respiratory system, regularly monitor patient blood pressure. When hypotension occurs, cardiovascular support includes high foot statistics and using the appropriate electrical substances.
If the hypotension is still not responding, the medication should be used (such as phenylephrin) along with monitoring the volume of circulation and the amount of urine released. Intravenous injection of calcium gluconate can reverse the effect of blocking the amount of calcium. Amlodipine is associated with high plasma proteins, so it is not beneficial to blood decomposition.

What to do when forgetting 1 dose? However, if the time to relax with the next dose is too short, skip the dose and continue the calendar of the drug. Do not use double dose to compensate for missed dose.

Side Effects

When using Amlodipin Stada 5, you may experience unwanted effects (ADR).

Common

Ankle edema, flushing, headache, skin rash and fatigue.

rarely

Cardiovascular: arrhythmia (including ventricular rapid and atrial fibrillation), slow heartbeat, chest pain, hypotension, peripheral ischemia, fainting, fast heart, posture stun, lower blood pressure, vasculitis.

Central and peripheral nervous system: Reduce sensory, peripheral neuropathy, paresthesia, tremor, dizziness .

Digestive: Anorexia, constipation , indigestion, difficulty swallowing, diarrhea , flatulence, pancreatitis, vomiting, gum hyperplasia.

Systemic: Hypersensitivity reaction, weakness, back pain, hot burning, discomfort, pain, cold tremor, increase or weight loss.

Mechanical system: joint pain, cramping, muscle pain.

Mental: Genital dysfunction (male and female), insomnia , panic, depression, dreaming, anxiety, loss of personality.

Respiratory system: Difficulty breathing, nosebleeds .

Skin and appendages: Evaluation, diverse roses, itching, rash, erythema, lumpy.

The senses: visual dysplasia, focal inflammation, double vision, eye pain, tinnitus .

Urinary tract: regular urine, non -control urine, night urine.

Autonomous nervous system: dry mouth , increase sweating.

metabolism and nutrition: hyperglycemia, thirst.

Hematopoietic system: leukopenia, hemorrhage, thrombocytopenia.

Other side effects

Myocardial infarction and angina.

When experiencing side effects of the drug, it is necessary to stop using and notify the doctor or go to the nearest medical facility for timely treatment.

Warnings

Before using the drug you need to read the instructions carefully and refer to the information below.

Contraindicated

Amlodipin Stada 5mg drug is contraindicated to patients with amlodipine, any other antagonistic drug or any ingredient of the drug.

Precautions when using

should use amlodipine caution in patients with hypotension, patients with low heart reserve, heart failure.

Do not use medication for patients with cardiac shock, myocardial infarction for 2-4 weeks earlier, unstable angina, treatment of angina in chronic stable angina.

Amlodipine may increase the risk of heart failure in patients with severe aortic stenosis. Stop using Amlodipine suddenly worsen angina.

Need to reduce the dose in patients with liver failure.

The ability to drive and operate machinery

Amlodipin has a small or moderate effect on driving and operating machinery. If the patient uses amlodipine with symptoms such as dizziness, headache, fatigue and nausea may impair the reaction ability. Need to be especially cautious when starting treatment.

Pregnancy and lactation period

There is no clinical data when taking the drug for pregnant and lactating women. Therefore, amlodipine should not be used during pregnancy, lactation or women who are likely to get pregnant unless they are taking effective contraception.

Medicinal interaction

Amlodipin is safe for diuretics, thiazid, alpha blockers, beta blockers, angiotensin transferring enzymes, long -lasting nitrate, glyceryl trinitrate under the tongue, non -steroid anti -inflammatory drugs, antibiotics and oral blood sugar drugs.

The effect of other drugs on amlodipine

cimetidine, grapefruit juice, antacids: concurrent with amlodipine does not significantly affect the pharmacokinetics of amlodipine.

Sildenafil : When Amlodipin and Sildenafil are shared, each drug shows hypotension.

The effect of amlodipine on other drugs

Atorvastatin , ethanol (alcohol): Sharing amlodipin with 80mg Atorvastatin or with ethanol does not significantly change the pharmacokinetic parameters in the stable state of Atorvastatin, Ethanol.

Digoxin: Sharing amlodipine with digoxin does not change the concentration of Digoxin in serum or the disposition of digoxin in the kidney.

warfarin : simultaneous use of amlodipin does not change the effects of warfarin on blood clotting time.

cyclosporin : Mobile pharmacokinetics with cyclosporin shows that amlodipin does not significantly change the pharmacokinetics of cyclosporin.

Storage

In closed packaging, dry in a dry place, avoid light, temperatures below 30⁰C.

To be out of reach of children.

Other drugs

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