Amlodipine EG 5mg Pymepharco medicine treats hypertension, angina (3 blisters x 10 tablets)

Dosage form Box of 3 blisters x 10 tablets
Specifications Amlodipine
Ingredient Myocardial ischemia, high blood pressure, angina

Ingredient

Composition information	Content
Amlodipine	5mg

Uses

indications

Amlodipin EG drug is indicated in the following cases:

Hypertension.

Stable angina. In smooth muscle cells in the heart and blood vessels.

Amlodipine's blood pressure mechanism is due to the effect of direct relaxation of the blood vessels of Amlodipin exactly, reducing angina has not been fully determined, but Amlodipine reduces the overall anemia burden due to the following two effects:

Amlodipin relaxes peripheral arteries and thus reduces the overall barrier of the heart (reducing the burden). Because the heart rate does not change, this burden reduces the heart to reduce energy consumption and oxygen needs of the heart muscle.

The mechanism of action of amlodipine may also include the relaxation of the main coronary arteries and coronary arteries, both in anemia and normal areas. This vasodilation increases the supply of oxygen to the heart muscle in patients with coronary artery spasms (Prinzmetal angina or angina) and reduces smoking coronary spasms.

In hypertension patients. 1 time/day shows a significant clinical hemolytic decrease in both lying position and standing throughout the 24 -hour dose. Due to the slow -on -effect trigger, fasting blood pressure is not one of the effects of amlodipine.

In patients with angina ballache, the use of amlodipine once a day increases the overall exertion time, the starting time of angina and time until the 1 mm ST remit and reduces the frequency of angina and reduces the use of nitroglycerin tablets.

Not yet detected amlodipine is related to any adverse effects on metabolism or changes in plasma lipids, and amlodipine suitable for use in asthma, diabetes and gout patients.

Dynamic pharmacokinetics

absorption: After taking treatment doses, Amlodipin is well absorbed with peak concentration in plasma reaching about 6 - 12 hours after drinking. Absolute bioavailability is about 64-80%.

Distribution: The distribution volume is about 21 l/kg. Amlodipine absorption is not affected by food. In vitro studies show that about 97.5% amlodipine during circulation is attached to plasma proteins.

Metabolism and excretion: A Amlodipin 35 - 50 hours of plasma is 35 - 50 hours and is suitable for the dosage of the drug once a day. The constant concentration of plasma is about 7-8 days of using the drug continuously. Amlodipine is metabolized largely in the liver into non -activity metabolites, with 10% of the original substance and 60% of the metabolites are excreted in the urine.

Before taking Amlodipine EG 5mg Pymepharco medicine treats hypertension, angina (3 blisters x 10 tablets)

How to use

amlodipin eG drugs for oral use.

Dosage

adults

For hypertension and angina, the normal starting dose is 5 mg/time/day, there is a maximum increase of 10 mg/time/day depending on the response of each patient.

In hypertension. Amlodipin has been used simultaneously with thiazid diuretics. Alpha chen, beta blockers or enzyme inhibitors in the form of angiotensin. For angina, amlodipine can be used in monomers or simultaneously with other angina anti -angina drugs on patients with angina against nitrate derivatives and/or appropriate beta blockers.

There is no need to adjust the amlodipine dose in case of simultaneous use with thiazid diuretics, alpha blockers, beta blockers or angiotensin -shift enzyme inhibitors.

Special subjects

Elderly

The ability to tolerate elderly and young patients is the same when using the same amlodipine dose. Recommendation of the usual dosage and should be cautious when increasing the dose.

Patients with liver failure

The recommended dose has not been set in patients with mild to medium liver failure; Therefore, the dose should be careful and the treatment begins with the lowest doses effectively. Amlodipine pharmacokinetic properties have not been studied in cases of severe liver failure. Should start using amlodipine from the lowest dose and increasing slowly in patients with severe liver failure.

Patients with renal failure

The change of amlodipine concentration in plasma is not related to the level of renal failure; Therefore, the usual dosage is recommended. Amlodipin cannot be separated.

Children with teenagers

Children and teenagers from 6 to 17 years old with hypertension

The oral hypertension starting dose is recommended in children from 6 -17 years of age of 2.5 mg/time/day, then may be increased to 5 mg/time/day if the desired blood pressure has not been achieved after four weeks. Doses higher than 5 mg/day/day have not been studied in children.

Children

No data.

Note: The above dose is for reference only. Specific dosage depends on the condition and level of progression of the disease. For a suitable dose, you need to consult a doctor or medical specialist.What do

do when overdose? There is a report on the drop of blood pressure, may be prolonged and including death shock.

Amlodipine absorption decreases significantly when indicating activated carbon right after or within 2 hours after taking Amlodipin 10 mg in healthy volunteers. In some cases, the stomach may need.

For cases of severe hypotension due to the overdose of amlodipine, positive cardiovascular support measures should be taken, including regular monitoring of cardiovascular and respiratory functions, including high limbs and attention to the volume of circulation and urine.

Can use a vasoconstrictor to recover blood vessels and blood pressure, as long as the patient does not have contraindicated use of the drug.

can be intravenous with calcium gluconate to reverse the effect of calcium channel blockers. Because amlodipine is heavily connected to plasma proteins, hemolysis does not bring results in this case.

What to do when you forget a dose? However, if close to the next dose, skip the forgotten dose and take the next dose at the time as planned. Note that it should not be used double the prescribed dose.

Side Effects

When using Amlodipin EG, you may experience unwanted effects (ADR).

Unwanted effects recorded after the drug is marketed include:

Blood disorders and lymph nodes: leukopenia, thrombocytopenia.

Metabolic and nutrient disorders: Hyperglycemia.

Mental disorders: Insomnia, Mind change.

neurological disorders: increase muscle tone, reduce tactile/paresthesia, peripheral neuropathy, unconsciousness, taste disorders, tremor, pagoda disorders.

visual disorders: visual impairment.

Hearing and inner ear disorders: tinnitus.

Vascular disorders: Hypotension, vasculitis.

Chest and mediastinum disorders: cough, shortness of breath, rhinitis. Gastrointestinal disorders: Change the habit of going out, dry mouth, indigestion (including gastritis), hyperplasia, pancreatitis, vomiting.

Skin and subcutaneous tissue disorders: hair loss, increased sweating, hemorrhage, skin color change, urticaria.

Disorders of musculoskeletal and connective tissue: joint pain, back pain, muscle contraction, muscle pain.
Kidney disorders and urinary systems: urination, urination disorders, night urination.

Reproductive disorders and mammary glands: big breasts in men, erectile dysfunction.

Systemic and local disorders: weakness, discomfort and pain.

Testing indicators: weight gain, lever.

Rare allergic reactions including itching, skin rash, angioedema and diverse roses. hepatitis: jaundice and increased liver enzymes have also been reported at very small rate (mainly with biliary obstruction). There are several serious cases needed to be reported related to the use of amlodipine. In many cases, the causal relationship between the above -mentioned effects and the use of amlodipine is unclear.
Like other calcium channel blockers, the following adverse effects are rarely reported and cannot be distinguished from the natural process of diseases: myocardial infarction, arrhythmia (including slow rhythm, ventricular and atrial rhythm) and chest pain.

Pediatric patients (6 - 17 years old)
Amlodipin tolerates well in children. These unwanted effects are similar to unwanted effects to observe in adults. In research with 268 children, the most unwanted effects are:

Nervous system disorders: headache, dizziness.

Vascular disorders: vasodilation.
Respiratory disorders: chest and mediastinum: nosebleeds.

Digestive disorders: abdominal pain.
Systemic disorders and on -site: weakness.

Most of the unwanted effects have a light or medium level. Serious unwanted effects (mainly headache) are observed in 7.2% of patients using amlodipine 2.5 mg; 4.5% use amlodipine 5 mg and 4.6% placebo.
The most common reason for stopping participating in research is uncontrolled hypertension. There is no case of stopping participating in any research related to abnormal test results. There is no significant change in heart rate.
Instructions on how to handle ADR
Notice immediately to the doctor or pharmacist the harmful reactions encountered when using the drug.

Warnings

Before using the drug you need to read the instructions carefully and refer to the information below.

Contraindicated

Amlodipine EG drug is contraindicated in the following cases:

Sensitive to Dihyropyridine, Amlodipine or any ingredient of the drug.

Serious hypotension.

SHARE (including cardiac shock).

Conclusion of the left ventricular ventricular (eg, heavy aortic stenosis).

Unstable hemodynamic heart failure after acute myocardial infarction.

Caution when using

used in heart failure patients.

Used in patients with liver function impairment.

The ability to drive and operate machinery

amlodipine may have a slight or medium impact to the ability to drive and operate machinery. If the patient uses amlodipine dizziness, headache, fatigue or nausea, their reaction possibility may be impaired. Patients need to be carefully warned, especially at the beginning of treatment.

Pregnancy

Amlodipine's safety in pregnant women has not been set. Amlodipine should only be used during pregnancy when there is no safer replacement and when the disease itself contains greater risks for mothers and embryos.

The period of breastfeeding

The safety of amlodipine in breastfeeding women has not been set. Experience used on humans shows that Amlodipine has passed through breast milk.

A Amlodipine median concentration rate in milk/plasma in 31 women who are breastfeeding with high blood pressure due to pregnancy is 0.85 after using amlodipine at the starting dose of 5 mg/time/day, this dose is adjusted if needed (average daily dose and daily dose of daily estimates of amlodipine that newborns receive through breast milk is 4.17 mcg/kg.

Drug interaction

amlodipin has been shown to be safe to use with thiazid diuretics, receptor inhibitors Alpha -adrenergic, Beta -adrenergic receptor inhibitors, ACE inhibitors, prolonged nitrate, nitroglycerin under the tongue, steroid anti -inflammatory drugs, antibodies and antibiotics.

Simvastatin: For patients with amlodipine, the dose limits of simvastatin and 20 mg/day.

Grapefruit juice: Do not use amlodipine along with grapefruit or grapefruit juice because bioavailability can increase in some patients leading to increased blood pressure effects.

CYP3A4 inhibitors: CYP3A4 strong inhibitors (such as ketoconazole, otraconazole, ritonavir) can increase the concentration of amlodipine in blood much larger than Ditiazem. Should be cautious when using amlodipine along with CYP3A4 inhibitors.

Clarithromycin: The risk of increased hypotension in patients using clarithromycin along with amlodipin. The patient should be closely monitored when using Amlodipin simultaneously with clarithromycin.

CYP3A4 induction substances: Be cautious when using amlodipine with CYP3A4 induction.

Storage

under 30 ° C, avoid moisture and light.

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