Amlodipine Stada 5mg Cap medicine for hypertension, angina (3 blisters x 10 tablets)

Dosage form Box of 3 blisters x 10 tablets
Specifications Amlodipine
Ingredient High blood pressure, angina

Ingredient

Composition information	Content
Amlodipine	5mg

Uses

Indications

Amlodipin Stada 5mg Cap 3x10 is indicated in the following cases:

Amlodipin is used to be used or combined with other anti -hypertension drugs to treat hypertension. Learning

amlodipin is a calcium antagonist in the dihydropyridine group (calcium ion antagonistic or slow channel blockers), inhibiting calcium flow through the cell membrane into the blood vessel and heart muscle. The process of vascular muscle and blood vessel muscles depends on the movement of extracellular calcium ions into these cells through specialized ions.

amlodipin selectively inhibits calcium flow through cell membranes, with the effects on blood vessel muscle cells better on myocardial cell. Amlodipine is a peripheral artery, directly acting on blood vessel smooth muscles, causing reduced peripheral vascular resistance and reducing blood pressure.

pharmacokinetic

absorption

After drinking, amlodipin is well absorbed by oral with peak blood concentration achieved after 6 - 12 hours.

Distribution

Birth changes but usually in the range of 60 - 65%. About 97.5% amlodipine is attached to plasma proteins. The final sale time lasts 35 - 50 hours and stable plasma concentrations achieved after 7-8 days of drug use.

Metabolism

Amlodipine is metabolized mostly in the liver.

Elimination

Amlodipin is excreted in urine with less than 10% of the dose in constant form. Amlodipine is not excluded by the method of appraisal.

Before taking Amlodipine Stada 5mg Cap medicine for hypertension, angina (3 blisters x 10 tablets)

How to use

Amlodipin Stada 5mg is used by oral and regardless of meals.

Dosage

Hypertension

Adults: Amlodipine's usual starting dose is 2.5 - 5mg x 1 time/day. The elderly and thin people should start the starting dose of 2.5mg x 1 time/day. The next dose should be adjusted depending on the blood pressure response and patient tolerance, usually not more than 10mg x 1 time/day. The usual maintenance dose to treat hypertension in adults is 5 - 10mg x 1 time/day.

Children 6 years of age and older: The usual dosage of amlodipine is 2.5 - 5mg x 1 time/day.

Angina

To treat the variable Prinzmetal variation or chronic stable angina, the dose commonly used for adults is 5 - 10mg x 1 time/day. Older people should take low doses, 5mg x 1 time/day. The maintenance dose is 10mg daily.

Note: The above dose is for reference only. Specific dosage depends on the condition and level of progression of the disease. For a suitable dose, you need to consult a doctor or medical specialist.

What to do when overdose?

Existing data suggests that large -scale overdose can cause peripheral vessels and may be accompanied by tachycardia. There is a report on strong hypotension, prolonged and including death shock.

How to deal with overdose drugs:

Use single dose amlodipine, respectively 40mg/kg and 100mg/kg respectively on mice and large mice can be fatal. Overdose can cause excessive peripheral vessels with symptoms of clear hypotension and is likely to cause fast heart due to reflexes.

If serious overdose occurs, it is necessary to monitor the activity of the heart and the respiratory system, regularly monitor patient blood pressure. When hypotension occurs, cardiovascular support includes high foot statistics and using the appropriate electrical substances.

If the hypotension is still not responding, the medication should be used (such as phenylephrin) along with monitoring the volume of circulation and the amount of urine released. Intravenous injection of calcium gluconate can reverse the effect of blocking the amount of calcium. Amlodipine is associated with high plasma proteins, so it is not beneficial to blood decomposition.

What to do when you forget a dose? However, if close to the next dose, skip the forgotten dose and take the next dose at the time as planned. Note that it should not be used double the prescribed dose.

Side Effects

When using Amlodipin Stada 5mg Cap 3x10, you may experience unwanted effects (ADR).

Common, ADR> 1/100

Ankle edema, flushing, headache, skin rash and fatigue.

Less

Cardiovascular: arrhythmia (including ventricular rapid and atrial fibrillation), slow heartbeat, chest pain, hypotension, peripheral ischemia, fainting, fast heart, posture, vertical blood pressure, vasculitis.

Central and peripheral nervous systems: reduce sensation, peripheral neuropathy, paresthesia, tremor, dizziness. digestive: anorexia, constipation, indigestion, difficulty swallowing, diarrhea, flatulitis, pancreatitis, vomiting, gum hyperplasia. Body: Hypersensitivity reaction, weakness, back pain, hotburging, discomfort, pain, cold tremor, increase or weight loss.

muscle - bone system: joint pain, cramping, muscle pain.

Mental: Genital dysfunction (male and female), insomnia, panic, depression, dreaming, anxiety, loss of personality.

Respiratory system: Difficulty breathing, nosebleeds.

Skin and appendages: angiography, diverse roses, itching, rash, erythema, lumpy.

The senses: visual disorders, focal inflammation, double vision, eye pain, tinnitus.

urinary tract: Regular urine, non -control urine, night urine.

Autonomous nervous system: dry mouth, increased sweating.

Metabolism and nutrition: hyperglycemia, thirst.

Hemorrhage system: leukopenia, hemorrhage, thrombocytopenia.

Other side effects:

Myocardial infarction and angina.

Warnings

Before using the drug you need to read the instructions carefully and refer to the information below.

Contraindicated

Ondanov Injection 8 mg is contraindicated in cases of hypersensitivity to amlodipine, any other antagonistic drug or any ingredient of the drug.

Precautions when using

should use amlodipine caution in patients with hypotension, patients with low heart reserve, heart failure.

Do not use medication for patients with cardiac shock, myocardial infarction for 2-4 weeks earlier, unstable angina, treatment of angina in chronic stable angina.

Amlodipine may increase the risk of heart failure in patients with severe aortic stenosis. Stop using Amlodipine suddenly worsen angina.

Need to reduce the dose in patients with liver failure.

The ability to drive and operate machinery

Amlodipine may have a slight or medium impact to the ability to drive, operate machinery. If the patient uses amlodipine dizziness, headache, fatigue or nausea, their reaction ability may be impaired. Patients need to be carefully warned, especially from the beginning of treatment.

Pregnancy

There is no clinical data when taking drugs for pregnant women. Therefore, amlodipine should not be used during pregnancy, lactation or women who are likely to get pregnant unless they are taking effective contraception.

Breastfeeding period

There is no clinical data when taking medication for nursing women. Therefore, amlodipine should not be used during pregnancy, lactation or women who are likely to get pregnant unless they are taking effective contraception.

Medicinal interaction

Amlodipin is safe for diuretics, thiazid, alpha blockers, beta blockers, angiotensin transferring enzymes, long -lasting nitrate, glyceryl trinitrate under the tongue, non -steroid anti -inflammatory drugs, antibiotics and oral blood sugar drugs.

The effect of other drugs on amlodipine

cimetidin, grapefruit juice, antacids: concurrent with amlodipine does not significantly affect the pharmacokinetics of Amlodipin.

Sildenafil: When Amlodipin and Sildenafil are shared, each drug shows hypotension.

The influence of amlodipine on other drugs

Atorvastatin, ethanol (alcohol): Sharing amlodipin with 80mg Atorvastatin or with ethanol does not significantly change the pharmacokinetic parameters in the stable state of Atorvastatin, Ethanol.

digoxin: Sharing amlodipine with digoxin does not change the concentration of Digoxin in the serum or Digoxin purification in the kidney.

warfarin: simultaneous use of amlodipin does not change the effects of warfarin on blood clotting time.

Cyclosporin: Dynamic research with cyclosporin shows that amlodipin does not significantly change the pharmacokinetics of cyclosporin.

Storage

In closed packaging, in a dry place, away from light. The temperature does not exceed 30 ° C.

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