AMMG-3B medication The longevity treatment of neurological diseases due to lack of vitamin B1, B6, B12 (5 blisters x 10 tablets)

Dosage form Box of 5 blisters x 10 tablets
Specifications Vitamin B1, Vitamin B6, Vitamin B12
Ingredient Fatigue, headache, sciatica, back pain, body aches, lack of B vitamins

Ingredient

Composition information	Content
Vitamin B1	100mg
Vitamin B6	200mg
Vitamin B12	200mcg

Uses

Indications

AMMG-3B drugs are indicated in the following cases of the treatment of neurological diseases caused by vitamin B1, B6, B12 deficiency.

Pharmacokology

Thiamin Nitrate (Vitamin B1):

Thiamin actually has no pharmacological effects, even at high doses. Thiamin combined with Adenosin Triphosphate (ATP) in the liver, kidneys and leukocytes to form Thiamin Diphosphate (Thiamin Pyrophosphate) with physiological activity.

thiamin pyrophosphate, the form of physiological activity, is the carbohydrate metabolism that reduces the carboxyl of alpha - cetoacids such as pyruvat and alpha - cetoglutarat and in the use of pentose in the HEXOSE MONOXOSONSPHAT cycle.

The amount of thiamin eat daily requires 0.9 - 1.5mg for men and 0.8 - 1.1mg for healthy women. Thiamin demand is directly related to carbohydrate and metabolic speed. This has practical significance in nourishing patients with intravenous tract and in patients with calorie energy taken mainly from Dexrose (Glucose).

During the shortage of Thiamin, the oxidation of alpha -cetoacids affected, causing the blood pyruvat level in the blood to increase the diagnosis of Thiamin deficiency.

The deficiency of Thiamin will cause Beriberi (numbness). Mild deficiency manifests on the nervous system (dry Beriberi) such as peripheral neuritis, sensory disorders, may increase or lose sensation. The muscle tone gradually decreases and can cause a limb or paralysis.

Severe deficit causes personality, depression, lack of innovation and poor memory like in Wernicke and if the late treatment causes mental rebellion Korsakoff.

Cardiovascular symptoms due to thiamin deficiency include exertion, chest drumming, tachycardia and other disorders on the heart are manifested by diabetes changes (mainly low R wave, reverse wave and extended segment 2 - T) and with heart failure with high cardiac weight. Such heart failure is called a wet, strong edema as a result of a decrease in blood protein if not enough protein, or of liver disease combined with ventricular failure.

Thiamin shortage may occur for many reasons:

Although available in food, due to the less durable with temperature and light, the improper storage and processing process will quickly reduce this vitamin content.

Due to the increasing demand, but not enough: puberty, pregnancy, breastfeeding, serious illness, alcoholism, nurturing venous sugar.

Due to reduced absorption: prolonged diarrhea, elderly.

Due to the loss of this vitamin when the peritoneal fertilizer, artificial kidney.

pyridoxin hydrochloride (vitamin B6):

Vitamin B6 exists in 3 forms: pyridoxal, pyridoxin and pyridoxamin, when entering the human body transforms into pyridoxal phosphate and partially into pyridoxamin phosphate. These two substances act as coenzymes in protein, glucid and lipid metabolism.

pyridoxin participates in gamma acid synthesis - aminobutyric (GABA) in the central nervous system and participates in hemoglobulin synthesis. Pyridoxin is quickly absorbed by the digestive tract, except for cases of malabsorption syndrome.

After injection or oral, the drug is mostly reserved in the liver and part of the muscle and brain. Pyridoxin excreted mainly through the kidneys in the form of metabolism. The amount of introduction, if exceeding the daily demand, most excreted in the form of unchanged.

Daily needs for children are 0.3 - 2mg, adults about 1.6 - 2mg and pregnant or lactating mothers are 2.1 - 2.2mg. Rarely the shortage of human vitamin B6, but can occur in the case of absorption disorders, congenital metabolic disorders or drug disorders caused by drugs.

For patients treated with isoniazid or women who take birth control pills, the daily vitamin B6 needs more than usual.

Many drugs such as pyridoxin antagonists: isoniazid, cycloserin, penicilamine, hydralazin and other carbonyl groups can be combined with vitamin B6 and inhibit the Coenzyme function of this vitamin.

pyridoxin is used to treat seizures and/or coma due to isoniazid poisoning. These symptoms are considered to be caused by reduction in gaba concentrations in the central nervous system, perhaps due to the inhibiting the activity of pyridoxal - 5 - phosphate in the brain.

pyridoxin is also used as a medicine to support other measures in the treatment of acute poisoning caused by fungus gyromitra to treat nervous effects (such as convulsions, coma) of methylhydrazin, hydrolyzed from gyrometrin toxin in these mushrooms.

cyanocobalamin (vitamin B12):

Two forms of vitamin B12, cyanocobalamin and hydroxocobalamin have the effect of blood creation. In the human body, these cobalamin forms coenzymes active, methylcobalamin and 5 deoxyadenosycobalamin is essential for copying and growth cells.

methylcobalamin is needed to create methionine and conduct as s-adenosylmethionin from homocystein.

In addition, when the level of vitamin B12 is not enough, it will cause a decline in the function of some other essential folic acid types in the cell. Hematology abnormalities among vitamin B12 deficiency are due to this process. 5 - Deoxyadenosycobalamin is needed for isomer, convert l - methylmalonyl coa into success coa.

Vitamin B12 is essential for all tissues with strong cell growth such as hematuria, small intestine, and uterus. Vitamin B12 deficiency also causes neuron cancellation.

pharmacokinetics

thiamin nitrate:

Thiamin absorption in daily eating through the gastrointestinal tract is due to the positive transportation of Na+. When Thiamin concentration in the digestive tract is highly passive diffusion. However, high -dose absorption is limited.

After intramuscular injection, Thiamin is also quickly absorbed, distributed into most tissues and milk.

In adults, about 1mg of Thiamin is completely struck every day in tissues, and this is the minimum amount of daily need. When absorbed at this low level, there are very little or no thiamin excreted through the urine. When absorbed beyond the minimum demand, Thiamin storage in the first tissues are saturated.

The excess amount will then be eliminated through the urine in the form of intact thiamin molecules. When Thiamin's absorption increases further, excretion in the form of unprocessed thiamin will increase.

pyridoxin hydrochloride:

pyridoxin is quickly absorbed through the gastrointestinal tract, except for malabsorption syndrome. After injection or oral, the drug is largely reserved in the liver and part of the muscle and brain. Pyridoxin excreted mainly through the kidneys in the form of metabolism.

The amount of introduction, if exceeding the daily demand, mostly eliminated in the form of unchanged.

cyanocobalamin:

After drinking, Vitamin B12 is absorbed through the intestine, mainly in the ileum in two mechanisms: the passive mechanism when the amount is high and the active mechanism, allowing the absorption of physiological doses, but it is necessary to have the intrinsic factor, Glycoprotein, which is secreted by the cells into the stomach mucosa.

The level of absorption is about 1% does not depend on the dose and therefore 1mg daily will satisfy the daily needs and sufficient to treat all types of vitamin B12 deficiency.

After intramuscular injection, the peak concentration in plasma is achieved after 1 hour.

After absorption, Vitamin B12 is linked to Transcobalamin II and is quickly removed from plasma to distribute priority to the liver parenchyma.

The liver is the storage of vitamin B12 for other tissues. About 3 micrograms of cobalamin excreted daily, of which 50 - 60% are the derivatives of cobalamin that cannot be reabsorbed.

Hydroxocobalamin is better absorbed through the gastrointestinal tract, and is affectionate with larger tissues than cyanocobalamin.

Before taking AMMG-3B medication The longevity treatment of neurological diseases due to lack of vitamin B1, B6, B12 (5 blisters x 10 tablets)

How to use

Take oral use.

Dosage

Use 1-3 tablets/day.

Note: The above dose is for reference only. Specific dosage depends on the condition and level of progression of the disease. For a suitable dose, you need to consult a doctor or medical specialist.

What to do when overdose?

What to do when you forget a dose? However, if close to the next dose, skip the forgotten dose and take the next dose at the time as planned. Note that it should not be used double the prescribed dose.

Side Effects

When using AMMG-3B, you may experience unwanted effects (ADR).

Unwanted effects can be encountered when using AMMG 3B: vomiting, nausea.

When used for more than 2 months can cause severe peripheral neuropathy, progressing from unstable gait and numbness to the numbness and clumsy hands (due to vitamin B6), this condition can recover when stopping the drug.

Unexpected effects (due to vitamin B12):

Body: Anaphylaxis, fever, headache, dizziness, bronchospasm, mouth angio - Most.

Dermatology: The reaction of acne, urticaria, erythema, itching. digestive: nausea.

Secondary arrhythmia due to hypokalemia at the beginning of treatment.

Instructions on how to handle ADR

When experiencing side effects of the drug, it is necessary to stop using and notify the doctor or go to the nearest medical facility for timely treatment.

Warnings

Before using the drug you need to read the instructions carefully and refer to the information below.

Contraindicated

AMMG-3B drug contraindicated in the following cases:

Hypersensitivity to one of the ingredients of the drug.

Collaborate with levodopa.

malignant.

Patients with allergies (asthma, eczema).

Caution when used

Do not take high and prolonged doses and vitamin B6 used at a dose of 200mg/day and prolonged can make peripheral neuropathy and neurological sensory severe sensory, in addition, it also causes vitamin B6.

Vitamin B6 can increase the peripheral metabolism of Levodopa, so Parkinson patients are being treated with Levodopa should not use vitamin B6 beyond their daily needs. This does not apply when Levodopa is used in combination with a peripheral carboxy enzyme inhibitor.

AMMG 3B is a tablet, so it should not be used for diabetics.

3B AMMG bags contain white sugar excipients so before taking this medicine, you need to notify your doctor if you do not tolerate a few types of sugar.

The ability to drive and operate machinery

has not recorded any cases affecting the ability to drive and operate machinery.

Pregnancy

only taking drugs during pregnancy when really necessary and as instructed by a physician.

Women during pregnancy if using high and prolonged vitamin B6 can cause drug dependence syndrome in infants.

Breastfeeding period

Only use drugs during breastfeeding when really necessary and according to the instructions of the physician.

Women during breastfeeding if using high and prolonged doses of vitamin B6 can cause drug dependence syndrome in infants.

Some special cases, high doses (vitamin B6> 600mg/day, divided 3 times) can inhibit milk creation.

Drug interaction

Vitamin B6 can increase the peripheral metabolism of Levodopa, thus reducing the effect of Levodopa.

Vitamin B6 at a dose of 200mg/day can reduce 40-50% of the concentration of phenytoin and phenobarbital in the blood in some patients.

Birth control pills can increase the demand for vitamin B6.

Storage

Places dry, avoid light, temperature not exceeding 30 ° C.

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