Amoksiklav Quick Tabs 625mg Lek Treatment of infection (7 blisters x 2 tablets)
Dosage form Box of 7 blisters x 2 tablets
Specifications Amoxicillin, clavulanic acid
Ingredient Soft oranges, urinary tract infections, skin infections and soft tissue, acute bronchitis, gonorrhea, upper respiratory tract infections, chronic bronchitis, pneumonia, osteoarthritis
Ingredient
Thành phần cho 1 viên
| Composition information | Content |
| Amoxicillin | 500mg |
| Clavulanic Acid | 125mg |
Uses
indication
Treatment of the following infections:
Skin infections and soft tissue, especially cellular inflammation, bite animal traces, severe tooth abscess with spreading tissue inflammation. Mechanism of action: Amoxicillin is a semi -synthetic penicillin (beta -lactam antibiotic group) inhibits one or more enzymes (often called penicillin - pbps) in the path of peptidoglycan biosynthesis of bacteria - is an indispensable structural component of the cell wall, peptidoglycan synthetic inhibitors lead to weakening cells, then cellular cells and cell death. Amoxicillin is easily decomposed by the beta-lactamase enzyme produced by resistance bacteria and thus the effect of amoxicillin alone does not include these enzymes. Clavulanic acid is a beta-lactam related structure with penicillin group. Clavulanic acid is inactivated some beta-lactamase enzymes thus preventing the inactivity of amoxicillin. Clavulanic acid simply does not cause any useful antibacterial effect on clinical. Resistance mechanism: The two main mechanisms of resistance for amoxicillin/clavulanic acid are: Waterproofing of bacteria or pumping mechanisms can cause or contribute to the resistance of bacteria, especially in gram -negative bacteria. Common sensitive strains: Gram-duong aerobic bacteria Enterococcus Faecalis, Gardnerella Vaginalis, Staphylococcus aureus (Methicilin), Streptococcus Agalactiae, Streptococcus Pneumoniae, Streptococcus Pyogenes and other Beta hemorrhagic streptococcus, Streptococcus viridans. Gram-noody bacteria capnocytophaga spp Anaerobic bacteria bacteroides fragilis, fusobacterium nucleatum, Prevotella spp. Anti -drug species may be the problem: Gram-duong aerobic bacteria Enterococcus fast. Gram-noody bacteria Escherichia Coli, Klebsiella Oxytoca, Klebsiella Pneumoniae, Proteus Mirabilis, Proteus Vulgaris. endogenous antimicrobial bacteria Gram-noody bacteria Acinetobacter sp., Citrobacter Freundii, Entobacter sp. Other bacteria Chlamydophila Pneumoniae, Chlamydophila Psittaci, Coxiella Burnetti, Mycoplasma Pneumoniae. absorption: amoxicillin and clavulanic acid are completely dissociated in water solutions in physiological pH. Both components are absorbed quickly and well by oral. After oral use, amoxicillin and clavulanic acid are about 70%. Plasma data of two similar components and time to reach the peak concentration in plasma (TMAX) is about 1 hour. Distribution: about 25% clavulanic acid and 18% amoxicillin in plasma are linked to protein. The apparent distribution volume is about 0.3 - 0.4 liters/kg for amoxicillin and about 0.2 liters/kg for clavulanic acid. After intravenous injection, both amoxicillin and clavulanic acid are found in the gallbladder, abdominal tissue, skin, fat, muscle tissue, animal substance and peritoneal, bile and latex. Amoxicillin does not distribute well into cerebrospinal fluid. Metabolism: Amoxicillin excreted in part in the urine in the form of penicilloic acid that is not active in about 10-25% of the initial dose. Most Clavulanic acid is metabolized in humans, eliminated in urine and feces and in the form of carbon dioxid gases in exhaled gas. Era: Amoxicillin is excreted by the kidneys, while clavulanic acid is eliminated through the kidneys and even without the kidneys. The average selling time of amoxicillin/ clavulanic acid is about 1 hour and the average total total clearance is approximately 25 liters/ hour in healthy people. About 60 - 70% amoxicillin and 40 - 65% Clavulanic acid are excreted in urine in the form of unchanged in the first 6 hours after using single doses of amoxicillin/clavulanic acid 250 mg/125 mg or 500 mg/125 mg. Pharmacology
pharmacokinetics
Before taking Amoksiklav Quick Tabs 625mg Lek Treatment of infection (7 blisters x 2 tablets)
How to use
Amoksiklav QuickTabs 625 mg tablets to mix the chewed in the blister containing 2 tablets. Firstly, divide the blister into 2 parts by the line on the blister. Peeled in the color of the triangle color and drags in the direction of the arrow. Do not press to remove the pills from the blister.
Figure 1 Figure 2 Figure 3
Mix each pill into 1/2 cup of water, stir well before drinking. You can put the pills in your mouth to disintegrate quickly then swallow.
Drugs are taken orally, along with meals to minimize the ability of the gastrointestinal intolerance.
Dosage
AMOKSIKLAV dose to treat a separate case of infection should be taken into account:
Because the dosage of the drug does not support the exact dosage division for children weighing less than 40 kg, the drug is only for adults and children weighing 40 kg or more.
For adults and children weighing over 40 kg, this Amoksiklav formula offers a total dose of 1500 mg of amoxicillin/375 mg of Clavulanic acid daily, when used as recommended below. If it is found to use a higher daily daily amoxicillin, it is recommended to choose another preparation to avoid high doses of clavulanic acid daily.
Duration of treatment should be determined according to the patient's response. Some cases of bacterial infections (eg bone inflammation) need longer treatment time. The treatment process should not last more than 14 days without review.
Adults and children weighs 40 kg or more: 1 tablet, 3 times/day.
Children weighing less than 40 kg: It is best to treat with amoxicillin/clavulanic acid, tablet form, oral fluid or children's package form.
Elderly: No dose needed.
Renal failure: Adjusting the dose based on the maximum Amoxicillin dose level is recommended.
No dose adjustment in patients with creatinine clearance (CLCR)> 30 ml/min.
Adults and children> 40 kg:
Clcr: 10-30 ml/minute
500 mg/125 mg, 2 times/day
500 mg/125 mg, 1 time/day
Dialy
500 mg/125 mg every 24 hours, plus 500 mg/125 mg while dialysis, repeated at the end of the dialysis (because the blood concentration of both amoxicillin and clavulanic acid decreases)
Note: The above dose is for reference only. Specific dosage depends on the condition and level of progression of the disease. For a suitable dose, you need to consult a doctor or medical specialist.What to do when overdose? Observed the amoxicillin crystal, in some cases, it can lead to renal failure. Convulsions can occur in patients with renal failure or in cases of high doses.
There has been a report on Amoxicillin precipitating in the bladder catheter, mainly after high -dose intravenous lines. Should maintain regular checkpoints.
How to handle:
Symptoms in the gastrointestinal tract may be treated as symptoms, should pay attention to water / electrolyte balance. Amoxicillin/Clavulanic acid can be removed from dialysis.
What to do when you forget a dose? However, if close to the next dose, skip the forgotten dose and take the next dose at the time as planned. Note that it should not be used double the prescribed dose.
Side Effects
When using Amoksiklav QuickTabs 625 mg, you may experience unwanted effects (ADR).
Common, ADR> 1/100
Uncommon, 1/1000 Bile liver system: increase AST, ALT. Rare, ADR Skin and subcutaneous tissue: Diverse roses. Not determined frequency: Blood and lymphatic system: recovery granulocytes, hemolytic anemia, prolonged bleeding time and prothrombin time. Digestive system: antibiotic colitis, black tongue. Hepatitis: hepatitis, jaundice. Skin and subcutaneous tissue: Stevens-Johnson syndrome, poisoned epidermal necrosis, flaking dermatitis, external pustular syndrome (AGEP), acidic reactions and systemic symptoms (Dress). Instructions on how to handle ADR: Nausea is often related to high doses. If the reactions of the gastrointestinal tract are clear, they can reduce them by using amoxicillin/clavulanic acid along with food. If any sensitive dermatitis is occurred, it is necessary to stop taking medication. When experiencing side effects of the drug, it is necessary to stop using and notify the doctor or go to the nearest medical facility for timely treatment.
Warnings
contraindicatedAmoksiklav QuickTabs 625 mg contraindicated in the following cases:
There is a history of jaundice/liver failure due to amoxicillin/acid clavulanic.
Be cautious when used
Before starting treatment with amoxicillin/clavulanic acid, careful survey should be conducted with previous hypersensitivity reactions with penicillin, cephalosporin or other beta-lactam antibiotics.
There have been reports on serious and sometimes fatal hypersensitivity cases (including anaphylactic reactions and serious harmful rules in the skin) in patients treated with penicillin. These reactions often occur in patients with a history of hypersensitivity to penicillin and have allergies. If any allergic reaction occurs, it is necessary to stop treating with amoxicillin/ clavulanic acid immediately and apply appropriate alternative treatments.
In the case of infection, it is shown that bacteria are sensitive to amoxicillin, which should be considered to switch from amoxicillin/ clavulanic acid to amoxicillin based on official instructions.
This type of presentation of amoxicillin/clavulanic acid is not suitable for use when there is a high risk of pathogens that reduce sensitivity or resistance to beta-lactam group without via beta-lactamase sensitive intermediaries-inhibited by clavulanic acid. This form of presentation should not be used to treat S. Pneumoniae resistance penicillin.
Should avoid using amoxicillin/clavulanic acid if suspected of mononulocytosis due to the appearance of measles rash after using amoxicillin.
The ability to drive and operate machinery
The drug can cause unwanted effects such as allergic reactions, dizziness, convulsions, need to be cautious when the ability to drive and operate machinery
Pregnancy
Animal studies do not show direct or indirect harmful effects on pregnancy, embryo/fetal development, childbirth or postpartum development.
Restricted data in the use of amoxicillin/clavulanic acid during pregnancy in humans does not show increased risk of birth defects. In a single study in premature, premature rupture of women, there was a report that the prophylactic treatment with amoxicillin/clavulanic acid may be associated with increased risk of necrotizing intestinal inflammation in infants. Should avoid using drugs during pregnancy, unless the doctor is considered necessary.
The period of breastfeeding. Therefore, diarrhea and fungal infection in the mucosa can occur in breastfeeding, may have to stop breastfeeding. Sensitivity should be taken into account.
Amoxicillin/Clavulanic acid should only be used during breastfeeding after being considered for benefits/risk by a doctor.
Interactive drugs
Oral anticoagulants: Use at the same time acenocoumarol or warfarin with amoxicillin can increase international standardization (INR), so carefully monitor prothrombin or INR time when extra or when stopping amoxicillin use. In addition, may need to adjust the oral anticoagulant dose.
Methotrexate: penicillin can reduce methotrexate secretion, increasing the risk of toxicity.
Probenecid: Probenecid reduces amoxicillin secretion in the renal tubules, causing prolonged increase in blood amoxicillin levels in the blood but does not affect the concentration of clavulanic acid.
Mycophenolat mofetil: amoxicillin and oral clavulanic acid can reduce the concentration of the activity of mycophenolat mofetil is mycophenolic acid (MPA) approximately 50%. It is necessary to closely monitor during simultaneous use of the drugs and a short time after the end of antibiotic treatment.
Storage
Store in closed packaging below 30 ° C.
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