Amoxicilin 500mg Thephaco treats infection (10 blisters x 10 tablets)

Dosage form Box of 10 blisters x 10 tablets
Specifications Amoxicillin
Ingredient Tonsillitis, pharyngitis, otitis media, sinusitis, urinary tract infections, skin and soft tissue infections, gonorrhea

Ingredient

Composition information	Content
Amoxicillin	500mg

Uses

Indications

Amoxicillin 500 mg Thephaco is indicated in the following cases:

Cases of bacterial infections that are still sensitive to amoxicillin causes the following diseases:

Upper respiratory infection;

Lower respiratory infections caused by streptococcal, pneumococcal, staphylococcus aureus without penicillinase and hinfluenzae;

Inhabited urinary tract infections; gonorrhea;

Bile infection;

Skin infections, muscles due to streptococcus, staphylococcus, E.coli sensitive to amoxicillin.

Pharmacokinus

amoxicillin is aminopenicilin, durable in acidic environment, with a spectrum that is wider than benzylpenicilin, especially anti -bacteria effect Gram negative. Similar to other penicillins, amoxicillin has bactericidal effects, due to inhibition of mucopeptide biosynthesis of bacterial cell walls.

In vitro, amoxicillin is active with the majority of Gram -negative and Gram -positive bacteria such as: bacterial streptococcus, non -penicillinase staphylococcus, H. Influenzae, Diplococcus Pneumoniae, N. Gonorrheae, E. Coli and Proteus Mirabilis. Like ampicilin, amoxicilin is not active with penicillinase secretion bacteria, especially staphylococcus aureus, all Pseudomonas strains and most of the Klebsiella and Entrecect strains.

Amoxicillin has a stronger printing effect than ampicilin for Enterococcus Faecalis and Salmonella spp, but less effective for Shigella spp. The effect of amoxicillin can be wider when used simultaneously with sulbactam and clavulanic acid, a beta - lactamase inhibitor. There has been a notice of E. coli resistant to amoxicillin in combination with clavulanic acid (16.8%).

Dynamic pharmacokinetics

amoxicillin sustainable in gastric acid environment. Absorption is not affected by food, faster and more completely through the gastrointestinal tract than ampicilin. When taken at the same dose like ampicillin, the concentration of amoxicillin peak in plasma is at least 2 times higher. Amoxicillin is quickly distributed into most tissue and meninges, except for brain tissue and cerebrospinal fluid, but when the meninges are inflamed, amoxicillin is easily diffused.

After taking the dose of 250 mg amoxicillin 12 hours, the blood amoxicillin level in the blood reaches about 4-5 micrograms/ ml, when taking 500 mg, the concentration of amoxicillin reaches about 8 - 10 micrograms/ ml. Double dose can increase the concentration of medication in the blood. Amoxicillin's half -life is about 61.3 minutes, longer in infants and the elderly. In people with kidney failure, the half-life of the drug is about 7-20 hours long.

About 60% of the oral dosage of amoxicillin discharged from the urine within 6 - 8 hours. Probenecid extends the waste time of amoxicillin through the kidney. Amoxicillin has high concentrations in bile fluid and a part of feces.

Before taking Amoxicilin 500mg Thephaco treats infection (10 blisters x 10 tablets)

How to use

Take oral use.

Dosage

The usual dose is 500 mg, every 8 hours

Children to 10 years old can use 1 tablet/time, every 8 hours.

Children under 20 kg often use the dose of 20 - 40 mg/kg body weight/day.

higher doses, single dose or in short phases, used in some diseases

3G dose, repeat again after 8 hours to treat abscesses around the teeth or repeat after 10 - 12 hours to treat uncomplicated urinary tract infections.

To prevent pericardial inflammation in humans susceptible, for a single dose 3g, 1 qi before the procedure such as tooth extraction.

Use high -dose regimen 3g Amoxicillin 2 times/day for patients with severe or recurrent respiratory infections.

If needed, children 3 - 10 years old otitis media can be used 750 mg/time, 2 times a day, for 2 days.

For people with renal failure, the dose must be reduced according to the creatinine clearance coefficient:

Cl Creatinin To dose treatment can reduce the absorption of the drug in the digestive tract by activated carbon, or cause vomiting to the patient. In some cases, if it is necessary to apply stomach lavage.

What to do when you forget a dose? However, if close to the next dose, skip the forgotten dose and take the next dose at the time as planned. Note that it should not be used double the prescribed dose.

Side Effects

When using amoxicillin, you may experience unwanted effects (ADR).

Common, ADR> 1/100

Foreigners (3 - 10%), usually appear slowly, after 7 days of treatment.

Uncommon, 1/1000

Digestive: Nausea, vomiting, diarrhea.

Hypersensitivity reaction: Red rash, lumpy and urticaria, especially Stevens - Johnson syndrome.

Rare, ADR

Liver: slight increase SGOT

Central nervous system: agitation, struggle, anxiety, insomnia, times, change behavior and/or dizziness. blood: Anemia, thrombocytopenia, thrombocytopenia, leukemia like eosin, leukopenia, granulocytosis.

Instructions on how to handle ADR

When experiencing side effects of the drug, it is necessary to stop using and notify the doctor or go to the nearest medical facility for timely treatment.

Warnings

Before using the drug you need to read the instructions carefully and refer to the information below.

contraindicated

Amoxicillin drug contraindicated for patients with a history of allergies to any penicillin and cephalosporin.

Caution when using

must periodically check the liver and kidney function during long -term treatment. A serious response may occur in patients with a history of allergies to peniclin or other nqi motors, so it is necessary to carefully investigate a history of allergies to penicillin, cephalosporin and other allergens.

If allergic reactions occur such as erythema, iridescent, anaphylactic shock, Stevens - Johnson syndrome, amoxicillin must be stopped and immediately treated emergency treatment with adrenalin, oxygen breathing, intravenous corticosteroidal therapy, including internal trachea and never being treated with penicilin or cephalosporin again.

The ability to drive and operate machinery

can be used

pregnancy

Amoxicillin safely used during pregnancy has not been clearly defined. Therefore, only this drug is needed during pregnancy. However, there is no evidence of harmful effects for the fetus when using Amoxidilin for pregnant women.

Lactation period

amoxicillin excreted into breast milk, so be cautious when taking the drug during breastfeeding.

Drug interaction

Absorption of amoxicillin is not affected by thick skin, so it can be taken before or after meals.

Nifedipine increases amoxicillin absorption.

When using allopurinol with amoxicillin will increase the ability of amoxicillin.

There may be antagonists of amoxicillin and bactericidal substances such as chloramphenicol, tetracyclin.

Storage

In a dry place, avoid light, the temperature does not exceed 300C.

Other drugs

Disclaimer

Every effort has been made to ensure that the information provided by Drugslib.com is accurate, up-to-date, and complete, but no guarantee is made to that effect. Drug information contained herein may be time sensitive. Drugslib.com information has been compiled for use by healthcare practitioners and consumers in the United States and therefore Drugslib.com does not warrant that uses outside of the United States are appropriate, unless specifically indicated otherwise. Drugslib.com's drug information does not endorse drugs, diagnose patients or recommend therapy. Drugslib.com's drug information is an informational resource designed to assist licensed healthcare practitioners in caring for their patients and/or to serve consumers viewing this service as a supplement to, and not a substitute for, the expertise, skill, knowledge and judgment of healthcare practitioners.

The absence of a warning for a given drug or drug combination in no way should be construed to indicate that the drug or drug combination is safe, effective or appropriate for any given patient. Drugslib.com does not assume any responsibility for any aspect of healthcare administered with the aid of information Drugslib.com provides. The information contained herein is not intended to cover all possible uses, directions, precautions, warnings, drug interactions, allergic reactions, or adverse effects. If you have questions about the drugs you are taking, check with your doctor, nurse or pharmacist.