Amoxicillin 500mg Domesco Treatment Treatment (10 blisters x 10 tablets)

Dosage form Box of 10 blisters x 10 tablets
Specifications Amoxicillin
Ingredient Urinary infections, cholecystitis, skin and soft tissue infections, upper respiratory tract infections

Ingredient

Composition information	Content
Amoxicillin	500mg

Uses

Indications

Amoxicillin 500 mg drug is indicated in the following cases:

Upper respiratory tract infection, sinusitis, otitis media. Staphylococcus, staphylococcus, E. coli sensitive to amoxicillin. typhoid. Amoxicillin has bactericidal effects, because the drug is attached to one or more penicillin -mounted proteins of bacteria (PBP) to inhibit peptidoglycan biosynthesis, which is an important component of bacterial cell walls. Finally, bacteria decomposed by self -destructing enzymes of bacterial cell walls.

Effective spectrum: Amoxicillin has anti -vitro activity against the majority of Gram -positive and gram -negative bacteria, some of the aerobic and anaerobic bacteria and some bacteria. The drug also has anti -vitro anti -vitro activity that some gas and taboos when grams, the drug has anti -Mycoplasma, Rickettsia, mushroom and virus effects.

sensitive bacteria:

Gram -positive gas: S.Aureus, S.epidermidis (no penicillinase), Streptococci group A, B, C and G; Streptococcus pneumoniae, Viridans Streptococci and some strains of Enterococci, Corynebacterium dipthenae, Listeria Monocytogenes, Bacillus anthracis, Erysipelothrix Rhusiopathiae, some Nocardia strains (although the majority of resistance). Neisseria meningitidis and n.gonorrhoeae (not creating penicillinase), Haemophilus influenzae and some H.Parainfluenzae and H.ducreyi strains, some Enterobacteriaceae, Proteus Mirabilis, Salmonella and Shigella, P.Vulgaris, Enterobacter Aerogues, Aererobacter Aereres,,,,,, Aidobacter Aerogaris CitrobacterFreundii, Vibrio Cholerae, Helicobacter Pylori, Bordetella Pertussis, Actinobacillus, Pasteurella Multocida, Gardnerella Vaginalis (Haemophilus Vaginalis), Moraxella CatinhLrhalis (Branhamella Catarrhalis) beta-lactamase.

Bacteria: Treponema Pallidum, Borelia Burgdoferi causes Lyme disease.

Gram-positive bacteria: Staphylococcus aureus). Klebsiella Oxytoca, Klebsiella Pneumoniae, Legionella, Morganella Morganii, Proteus Rettgeri, Proteus Valgaris, Providencia, Pseudomonas, Seratia, Yersinia Enterocolitica. Mycobacterium, Mycoplasma, Rickettsia.

Amoxicillin is sustainable in gastric acid environment. Amoxicillin absorption is not affected by food, Amoxicillin is faster and more absorbed by gastrointestinal tract compared to ampicillin. Maximum drug concentration in the blood and area under the concentration - time (AUC) curve increases with the dose increase.

Distribution

Amoxicillin quickly distributed into most tissues and fluids in the body, except for brain tissue and cerebrospinal fluid, but when the meninges are inflamed, amoxicillin is easily diffused. The drug passes through the placenta and small amounts distributed in breast milk. Amoxicillin binds plasma protein at 17-20%.

Metabolism

Amoxicillin is partially converted into penicilloic acid without bacterial activity.

Elimination

In adults with normal kidney function, serum amoxicillin clearance coefficient is 283 ml/min. About 43 - 80% of the amoxicillin oral dosage excreted the urine within 6 - 8 hours, with 5 - 10% of oral dose distributed into the bile. Probenecid extends the waste time of amoxicillin through the kidney. Amoxicillin has high concentrations in bile fluid and an excretion through feces.

Before taking Amoxicillin 500mg Domesco Treatment Treatment (10 blisters x 10 tablets)

How to use

Amoxicillin 500 mg orally before or after meals.

Dosage

Sensitive bacteria in the ear, nose, throat, skin, urinary tract:

Adults: Mild, medium infection: 1 tablet 500 mg 2 times/day. Severe infections: 1 tablet of 500 mg x 3 times/day. Severe infections: 40 - 45 mg/kg/day 8 hours/time.

in 7 days. After that, 20 mg of omeprazol (or 30 mg Lansoprazol) per day for 3 more weeks if the duodenal ulcer progresses, or 3-5 weeks if the stomach ulcer progresses.

Preventive infection infection:

Adults: a single dose of 2 g, take 1 hour before doing the procedure.

10 kg: a single dose of 50 mg/kg, take 1 hour before doing the procedure.

Adults: 500 mg/time, 3 times/day for 28 days.

CLCR The above dose is for reference only. Specific dosage depends on the condition and level of progression of the disease. For a suitable dose, you need to consult a doctor or medical specialist.

What to do when overdose? Amoxicillin is eliminated when the blood decomposes, usually the process of feces from 4 to 6 hours will remove 30-40% of the doses of tumors if taking the drug immediately before the fertilizer. Symptomatic treatment, special attention to water -electrolytes.

What to do when forgetting 1 dose? However, if the time to relax with the next dose is too short, skip the dose and continue the calendar of the drug. Do not use double dose to compensate for missed dose.

Side Effects

When using Amoxicillin 500 mg domesco, you may experience unwanted effects (ADR).

Common, ADR> 1/100

Outdoor (appear slow after 7 days of treatment), nausea, vomiting, epigastric pain, diarrhea in adults, higher rate in children and the elderly (loose stools in 42% of children under 8 months, 20% in children from 8 -16 months and 8.5% in children 24 - 36 months).

Uncommon, 1/1000

Redders, lumpy and urticaria, especially Stevens -Johnson syndrome.

Instructions on how to handle ADR

Amoxicillin's undesirable reactions in the gastrointestinal tract, in blood often disappear when stopping treatment. When colitis has a fake membrane, it is necessary to compensate for water, electrolytes and proteins; Metronidazol and vanicomycin treatment.

urticaria, other types of rash and serum -like reactions can be treated with antihistamine, and if necessary, using systemic corticosteroid therapy. However, when such a reaction occurs, amoxicillin must be stopped, unless there is a physician's opinion in special cases, life -threatening that only Amoxicillin can solve.

If the allergic reaction is stopped, Amoxicillin is stopped and immediately treated emergency treatment with adrenalin, oxygen breathing, intravenous corticosteroids and ventilation, including endotracheal placement and never being treated with penicillin or cephalosporin. Notify the doctor the unwanted effects when using the drug.

Warnings

Before using the drug you need to read the instructions carefully and refer to the information below.

Contraindicated

Amoxicillin 500 mg domesco contraindicated in cases where there is a history of allergies to any type of penicillin or any ingredient of the drug.

Precautions when using

must periodically check the hematology index, liver and kidney function during long -term treatment.

There may be severe hypersensitivity reactions in patients with a history of allergies to penicillin or other allergens, so before starting treatment with amoxicillin, a thorough survey of allergies with penicillin, cephalosporin and other allergens.

High doses of amoxicillin for kidney failure or a history of convulsions, epilepsy can cause seizures, though rare.

In the kidney failure, the dose must be adjusted according to the evaporation of creatinine or blood creatinine.

Little mini is a risk for crystallized drugs, having to drink plenty of water when taking the drug.

In the treatment of Lyme disease, attention should be paid to the Jarisch-HERXHEIMER reaction.

There is a high risk of a rash in patients with monon cellular hyperpses.

The ability to drive and operate machinery

The drug can cause dizziness (rare) effect. Be cautious when driving and operating machinery.

Pregnancy

only use this drug when really necessary during pregnancy. However, there is no evidence of harmful effects for the fetus when using amoxicillin for pregnant women. Amoxicillin is a drug chosen to treat chlamydia infection and treat skin coal or prevent after exposure to Bacillus anthracis spores in pregnant women.

Breastfeeding period

Amoxicillin excreted in breast milk, but the amount of medicine in milk is very small and safe for newborn babies in the common dose, so they can be used for women in the nursing period, closely monitor young children when used.

Drug interaction

nifedipine increases amoxicillin absorption.

Patients with hyperuricemia when using allopurinol along with amoxicillin will increase the ability of amoxicillin.

There may be antagonists between amoxicillin killer and bactericidal substances such as fusidic acid, chloramphenicol, tetracycline.

Amoxicillin reduces methotrexate secretion, increases toxicity on the gastrointestinal tract and hematoma.

Oral contraceptive pills: Amoxicillin has the ability to reduce contraception.

Typhoid vaccine: Amoxicillin reduces the effect of the vaccine.

warfarin: The studies do not prove interactive but experience shows that the anticoagulant effect has influenced the effect of simultaneous use of Warfarin with amoxicillin.

Probenecid when taken right before or simultaneously with amoxicillin reduces amoxicillin elimination, thereby increasing the level of cmax and the sale time to 30-60%, increasing the area under the concentration curve by the time of the hit (AUC) to 60%, thereby increasing the concentration of drugs in blood.

Storage

In a dry place, temperatures below 30 ° C, avoid light.

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