Amoxycilin 500mg Vidipha Treatment of infection (10 blisters x 10 tablets)

Dosage form Box of 10 blisters x 10 tablets
Specifications Amoxicillin
Ingredient Urinary infection, skin and soft tissue infection, gonorrhea infection, upper respiratory tract infection

Ingredient

Composition information	Content
Amoxicillin	500mg

Uses

Indications

Amoxicillin 500mg drug is indicated in cases where bacteria are still sensitive to amoxicillin in the following diseases:

Respiratory infections above.

Lower respiratory infections due to streptococcal, pneumococcal, staphylococcus a staphylococcus non -secretion of penicillinase and H. Influenzae.

Urinary tract infections

gonorrhea .

Bile infection.

Skin infections, muscles due to streptococcus, staphylococcus aureus, E. coli sensitive to amoxicillin.

Pharmacokology

amoxicilin is aminopenicilin, durable in acidic environment, with a wider spectrum than benzylpenicilin, especially anti -bacteria. Similar to other penicillins, amoxicillin has a bactericidal effect, due to inhibition of mucopeptide biosynthesis of bacterial cell walls. In vitro, amoxicillin is active with the majority of Gram -negative and Gram -positive bacteria such as: streptococcal, staphylococcus aureus does not produce penicillinase, H.influenzae, diplococcis pneumoniae, N.Gonorrheae, E.coli and Proteus Mirabilis. Like ampicilin, amoxicilin is not active with penicillinase secretion bacteria, especially staphylococcus aureus, all Pseudomonas strains and most of the Klebsiella and Entrecect strains.

Amoxicilin has a stronger printing effect than ampicilin for Enterococcus Faecalis and Salmonella spp., but less effective for Shigella spp. There has been a notice of E.coli resistant to amoxicillin in combination with clavulanic acid (16.8%).

According to the announcement No. 2 and No. 3 of the National Monitoring Program on the drug resistance situation of common pathogenic bacteria (ASTS), E.coli's level of ampicillin resistance is 66.7%, Salmonella Typhi is 50%, Shigella is 57.7%, acinetobacter spp. 70.7%, other intestinal bacteria (Citrobacter, Entobacter, Klebsiella, Morganella, Proteus, Serratia, ...) are 84.1%, Streptococcus spp. is 15.4% of the enterbacter spp. is 13.1% and other Gram -negative bacilli strains (Achromobacter, Charymonas, Flavobacterium, Pasteurella ...) are 66.7%.

pharmacokinetics

amoxicillin sustainable in gastric acid environment. Absorption is not affected by food, faster and more completely through the digestive tract than ampicilin. When taken at the same dose like ampicillin, the concentration of amoxicillin peak in plasma is at least 2 times higher. Amoxicillin is quickly distributed into most tissues and fluids in the body, except for brain tissue and cerebrospinal fluid, but when the meninges are inflamed, the amoxicillin diffuses easily.

After taking the dose of 250mg amoxicillin 1 - 2 hours, the blood amoxicillin level in the blood reaches about 4 - 5microgam/ml. Double dose can increase the concentration of medication in the blood. Amoxicillin's half -life is about 61.3 minutes, longer in infants and the elderly. In people with kidney failure, the half-life of the drug is about 7-20 hours long.

About 60% of the oral dosage of amoxicillin discharged from the urine within 6 - 8 hours. Probenecid extends the waste time of amoxicilin through the kidney. Amoxicillin has high concentrations in bile fluid and a part of feces.

Before taking Amoxycilin 500mg Vidipha Treatment of infection (10 blisters x 10 tablets)

How to use

Take the tablet with a glass of water.

Dosage

Adults

Often used 500mg, 3 times/day.

This form of preparation is not suitable for children under 10 years old.

Treatment time should last at least 7 to 10 days.

For kidney failures

Must reduce the dose according to creatinine clearance (cc):

cc from 10ml to 30ml/minute: 500mg every 12 hours.

500mg every 24 hours and 1 additional dose while being separated and after the cup.

Note: The above dose is for reference only. Specific dosage depends on the condition and level of progression of the disease. For a suitable dose, you need to consult a doctor or medical specialist.

What to do when overdose?

Handling: Control of electrolyte balance in case of symptoms of stomach -intestinal disorders.

What to do when forgetting 1 dose? However, if the time to relax with the next dose is too short, skip the dose and continue the calendar of the drug. Do not use double dose to compensate for missed dose.

Side Effects

When using Amoxicillin 500mg, you may experience unwanted effects (ADR).

Common

Outpatents often appear slowly, after 7 days of treatment.

rarely

Digestive: Nausea, vomiting, diarrhea.

Hypersensitivity reactions: Red rash , rash and , especially Stevens-Johnson syndrome.

rarely

Liver: slight increase SGOT.

Central nerve: agitation, struggle, anxiety, insomnia , confusion, behavior change or dizziness.

Blood: Anemia , thrombocytopenia, hemorrhage, leukemia like eosin, leukemia, granulocytes.

Note: Notify the doctor the unwanted effects encountered when using the drug.

Warnings

Drugs used by the doctor. Before using the drug, you need to read the user manual carefully and refer to the information below.

Contraindications

Patients with a history of allergies to antibiotics β - lactam.

Precautions when using

periodically check the liver and kidney function during long -term treatment.

There may be severe hypersensitivity reactions in patients with a history of allergies to penicillin or other allergens, so it is necessary to carefully investigate the history of allergies to penicillin, cephalosporin and other allergens.

If allergic reactions such as erythematosus, quincke edema, anaphylactic shock , Stevens-Johnson syndrome must stop amoxicillin therapy and immediately treat emergency treatment with adrenalin, oxygen, corticosteroid therapy intravenously and ventilate, including intravotics and never be treated with penicilin or cephalosporin.

Do not use drugs

The pills are discolored, dented, cracked.

The ability to drive and operate machinery

There is no document.

Pregnancy

Amoxicillin safety use during pregnancy has not clearly defined. Therefore, only this drug is needed during pregnancy. However, there is no evidence of harmful effects for the fetus when using amoxicillin for pregnant women.

Breastfeeding period

Because amoxicillin is excreted in breast milk, it is necessary to be cautious when taking the drug during breastfeeding.

Drug interaction

Nifedipine increases the absorption of amoxicillin.

When taken with alopurinol, increasing the ability of amoxicillin.

There may be antagonists between amoxicillin and alkaline bacteria such as chloramphenicol, tetracyclin.

Storage

Leave a cool place, avoid light, temperature below 30⁰C.

To be out of reach of children.

Other drugs

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