Ampicilin 500mg Thephaco treatment for infection (10 blisters x 10 tablets)

Dosage form Box of 10 blisters x 10 tablets
Specifications Ampicillin
Ingredient Sore throat caused by streptococcal, meningitis caused by streptococcal, upper respiratory tract infections

Ingredient

Composition informationContent
Ampicillin500mg

Uses

indications

Ampicillin 500mg drugs are indicated in the following cases:

Treatment of bacterial infections caused by sensitive bacteria:

  • Upper respiratory tract infection: Sinusitis, otitis media, chronic bronchitis powder and laryngitis caused by sensitive bacteria strains.
  • Urinary tract infections.
  • Some other infections are sensitive: Treatment of typhoid, listerin infection, gonorrhea due to gonococcus ...

    • Pharmacokinus

    ampicilin is a broad -spectrum antibiotic that works on both Gram -positive and gram -negative bridges: Streptoccoccus, Pneumococcus and Staphylococcus without penicilinase. However, the effect on the streptococcus beta and pneumococcus is lower than the benzyl penicillin.

    Ampicilin also works on meningococcus and gonococcus. Ampicilin has a good effect on some gram -negative bacteria such as E. Coli, Proteus Mirabilis, Shigella, Salmonella. With antibacterial spectrum and pharmacokinetic properties, ampicillin is often chosen as a medicine for urinary tract infections, cholecystitis and cholangitis.

    Ampicilin does not work on some gram -negative bacteria such as: Pseudomonas, Klebsiella, Proteus. Ampicilin also does not work on anaerobic bacteria (bacteroides) causing abscess and infection wounds in the abdominal cavity. In severe bacterial infections from the intestine or vagina, ampicilin is replaced by a combination of clindamycin + aminoglycosides or metronidazol + aminoglycosides or metronidazol + cephalosporin.

    The following is the sensitivity of some bacterial species for ampicillin (according to the antibiotic laboratory of Bach Mai Hospital 1996).

    region

    Samples

    %

    bacteria

    sensitive

    r

    i

    S

    11 - 21

    99

    85.9

    12,1

    2

    11 - 21

    8

    12.5

    18,8

    43,8

    11 - 21

    94

    80.9

    19,1

    Shigella Jlexneri

    11 - 21

    43

    86

    7

    7

    11 - 21

    6

    33,3

    0

    66,7

    Dynamic pharmacokinetics

    oral dose of 0.5 g, after 2 hours will have peak concentration in serum about 3 mg/liter.

    In pregnant women, serum concentration is only 50% compared to non -pregnant women, because in pregnant women, ampicillin can be distributed much larger and ampicillin diffuses through the placenta during fetal circulation and amniotic fluid.

    ampicilin does not pass the blood - brain barrier. In pus meningitis, due to the inflammation of the blood - the brain and the permeability changes, the ampicillin is usually penetrated into the central nervous system enough to have the effect, and the medium concentration of the medication in the cerebrospinal fluid reaches 10 - 35% of the serum concentration.

    Ampicillin is excreted quickly as approximately like benzyl penicillin, mainly through renal tubules (80%) and bile ducts.

    For gonorrhea, a single dose can be taken with ampicilin along with probenecid, this drug reduces ampicillin elimination through the renal tubules.

    About 20% ampicillin binds to plasma proteins.

    ampicilin excreted in milk.

    Before taking Ampicilin 500mg Thephaco treatment for infection (10 blisters x 10 tablets)

    How to use

    Take 30 minutes before meals or 2 hours after meals.

    Dosage

    Ampicillin dose depends on the type of disease, severity, age and kidney function of the patient. The dose is reduced in people with kidney failure.

    Recommended dose:

    Adults:

    Take 1 - 2 capsules/ time, every 6 hours.

    Children:

  • Respiratory or skin infections: Children weigh below or equal to 40 kg: 25 - 50 mg/kg/day equally divided, 6 hours/time.
  • Urinary tract infections: 50-100 mg/kg/day, 6 hours/time.

    • Renal failure:

  • Creatinine clearance 30 ml/min or higher: No need to change the usual dose in adults.
  • Creatinine clearance 10 ml/min or below: Give the usual dose every 8 hours/time.

    • Patients with dialysis must take an additional dose of ampicillin after each time of appraisal.

    Note: The above dose is for reference only. Specific dosage depends on the condition and level of progression of the disease. For a suitable dose, you need to consult a doctor or medical specialist.What do

    do when using overdose? However, in the process of using the drug, if there is an abnormal manifestation that affects the health of the patient, it is necessary to immediately take to the medical facility for examination and treatment.

    What to do when you forget a dose? However, if close to the next dose, skip the forgotten dose and take the next dose at the time as planned. Do not drink twice as prescribed.

    Side Effects

    When using ampicillin 500mg, you may experience unwanted effects (ADR).

    Common, ADR> 1/100

  • Digestive: diarrhea.
  • Skin: Red skin.

    • Uncommon, 1/1000

  • Blood and hematopoietic system: Anemia, thrombocytopenia, Eosin hypernagus, leukopenia and granulocytes.

    • digestion: inflammation of tongue, stomatitis, nausea, vomiting, colitis, fake colitis.

    Rare, 1/10,000

  • Systemic: The response of the whole body.
  • Skin: Dermatitis and erythema.

    • Instructions on how to handle ADR

    When experiencing side effects of the drug, it is necessary to stop using and notify the doctor or go to the nearest medical facility for timely treatment.

    Warnings

    Before using the drug you need to read the instructions carefully and refer to the information below.

    Contraindicated

    Ampicilin 500mg contraindications in the following cases:

  • There is a history of hypersensitivity to penicillin.
  • In case of an allergy to cephalosporin, it is not used ampicillin.

    • Be cautious when using

    cross -allergies with penicillin or cephalosporin.

    Do not use ampicilin for people who are sensitive to cephalosporin.

    Long treatment time (2-3 weeks) should check the liver and kidney function.

    The ability to drive and operate machinery

    can take the drug while driving or operating machinery.

    Pregnancy

    There is no risk of harm to pregnancy.

    Breastfeeding period

    ampicilin secreted into breast milk, but does not cause harmful reactions to breastfed children if used in normal treatment dose.

    Drug interaction

    ampicillin interacts with methotrexate, probenecid with allopurinol, in patients using ampicilin or amoxicilin along with allopurinol, rising redness.

    Pliers antibiotics such as chloramphenicol, tetracydin, erythromycin reduces the bactericidal ability of ampicilin and amoxicilin.

    Storage

    In a dry place, avoid light, temperature not exceeding 30 ° C.

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    Disclaimer

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