Ampicilin 500mg Vidipha Treatment of infection (10 blisters x 10 tablets)

Dosage form Ampicillin
Specifications Sore throat due to streptococcal, otitis media, sinusitis, meningitis caused by streptococcal, upper respiratory tract infections
Ingredient Drug allergy

Ingredient

Composition information	Content
Ampicillin	500mg

Uses

Indications

ampicillin 500 mg drug is indicated in the following cases:

Treatment of upper respiratory tract inflammation caused by Streptococcus Pyogenes, Streptococcus Pneumoniae, Haemophilus Influenzae. Ampicilin effectively treat sinusitis, otitis media, chronic bronchitis and laryngitis caused by sensitive bacteria strains. Listeria: Listeria monocytogenes bacteria are very sensitive to ampicilin, so ampicilin is used to treat Listeria infection. Impact on the multiplication of bacteria, inhibit the synthesis of mucopeptides of bacterial cell membranes.

Antibacterial Street:

Ampicilin is a broad -spectrum antibiotic that works on both gram -positive and gram -negative bacteria: Streptococcus, Pneumococcus and Staphylococcus without penicillinase. However, the effect on the streptococcus beta and pneumococcus is lower than the benzyl penicillin.

Ampicilin also works on meningococcus and gonococcus. Ampicilin has a good effect on some gram -negative bacteria such as E.coli, Proteus Mirabilis, Shigella, Salmonella. With antibacterial spectrum and pharmacokinetic properties, ampicillin is often chosen as a medicine for urinary tract infections, cholecystitis and cholangitis.

Ampicilin does not work on some gram -negative bacteria such as: Pseudomonas, Klebsiella, Proteus. Ampicilin also does not work on anaerobic bacteria (bacteroides) causing abscess and infection wounds in the abdominal cavity. In severe bacterial infections from the intestine or vagina, ampicilin is replaced by a combination of clindamycin + aminoglycosides or metronidazol + aminoglycosides or metronidazol + cephalosporin.

pharmacokinetic

absorption

In pregnant women, serum concentration is only 50% compared to non -pregnant women, because in pregnant women, amoeba can be distributed much larger and ampicillin diffuses through the placenta during the circulation of the fetus and into amniotic fluid.

Distribution

ampicilin does not pass the blood - brain barrier. In pus meningitis, due to the inflammation of the blood - the brain and the permeability changes, the ampicillin is usually penetrated into the central nervous system enough to have the effect, and the medium concentration of the medication in the cerebrospinal fluid reaches 10 - 35% of the serum concentration.

Metabolism

About 20% ampicillin binds to plasma proteins.

Elimination

Ampicillin is approximately approximately excreted as benzyl penicillin, mainly through the renal tubules (80%) and bile ducts. Usually 6 - 8 hours apart, add new dose to maintain concentration.

For gonorrhea, a single dose can be taken with ampicilin along with probenecid, this drug reduces ampicillin elimination through the renal tubules.

ampicilin excreted in milk.

Before taking Ampicilin 500mg Vidipha Treatment of infection (10 blisters x 10 tablets)

How to use

Avoid taking medication at meals.

Take medicine 30 minutes before meals or 2 hours after meals.

Dosage

Adults:

Usually 0.25 g - 1 g/time, every 6 hours with serious illness can be taken 6 - 12 g/day.

Treatment of uncomplicated gonorrhea due to ampicillin sensitivity strains, usually used for 2.0 - 3.5 g, combined with 1 g of probenecid, taking a single dose for women can repeat once if necessary.

Children:

Respiratory or skin infections: Children weigh below or equal to 40 kg: 25 - 50 mg/kg/day, divided equally, 6 hours/time.

Urinary tract infections: 50 - 100 mg/kg/day, 6 hours/time.

People with kidney failure:

Creatinine clearance 30 ml/min or higher: No need to change the usual doses in adults.

Creatinine clearance 10 ml/min or below: Give usual dose every 8 hours/time.

Patients with dialysis must take an additional dose of ampicilin after each time of appraisal.

Note: The above dose is for reference only. Specific dosage depends on the condition and level of progression of the disease. For a suitable dose, you need to consult a doctor or medical specialist.

What to do when using overdose?

What to do when forgetting a dose? Do not take two doses at the same time.

Side Effects

When using ampicillin 500 mg, you may experience unwanted effects (ADR).

Common, ADR> 1/100

Digestive: diarrhea

Blood: Anemia, thrombocytopenia, eosinophilia prefer eosin, leukopenia and granulocytosis.

Systemic body: Anaphylaxis reaction, diverse dermatitis and erythema. If a person with mononulocytosis is treated with ampicillin, 7-12 days after the first treatment, almost 100% of the patients often have very strong red rash. These reactions are also seen in patients with single -blood leukemia caused by cytomegalovirus and lymphocytic leukemia. Single leukemia patients have responded to other penicillin tolerances (except ampicillin esters such as Pivampicilin, Bacampicilin).

Notify the doctor with unwanted effects when using the drug.

Warnings

Before using the drug you need to read the instructions carefully and refer to the information below.

Contraindicated

Ampicillin 500 mg is contraindicated in cases where people are sensitive to one of the ingredients of the drug.

Be cautious when used

cross allergy with penicillin or cephalosporin. Do not use or absolutely cautious use ampicilin for people who have been sensitive to cephalosporin.

Long treatment time (more than 2-3 weeks) needs to check the liver and kidney function.

The ability to drive and operate machinery

There is no information on the effect of the drug on driving and operating machinery.

Pregnancy

There are no harmful reactions to the fetus.

Breastfeeding period

ampicillin into milk but does not cause harmful reactions for breastfed babies if used in normal treatment.

Drug interaction

Penicilin all interact with methotrexate and probenecid. Ampicillin interacts with alopurinol. In patients using ampicillin or amoxicillin along with alopurinol, the ability to redness increases.

Pliers antibiotics such as chloramphenicol, tetracyclin, erythromycin reduces the bactericidal ability of ampicilin and amoxicilin.

Storage

Store in a dry place, the temperature does not exceed 30 ° C, avoiding light.

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