Ampicillin 1g Mekophar injection powder for infection treatment (1g)
Dosage form Bottle x 1g
Specifications Ampicillin
Ingredient Urinary infection, bacterial meningitis, chronic bronchitis
Ingredient
| Composition information | Content |
| Ampicillin | 1g |
Uses
indicated
ampicilli indicated treatment in the following cases:
Mechanism of action: Ampicillin acts on bacterial multiplication, inhibits the synthesis of mucopeptides of bacterial cell walls.
Dynamic pharmacokinetics
After the injection of 1 dose of 500mg, after 1 hour of achieving the peak concentration in the serum is 8 - 10mg/liter, with half -life excreted is 80 minutes.
Distribution: about 20% ampicillin binds to plasma proteins. Ampicillin has a large distribution, diffuse through the placenta, the circulation of the fetus and the amniotic fluid.
Elimination: Ampicillin excreted quickly, mainly through the renal tubules (80%) and bile duct.
Before taking Ampicillin 1g Mekophar injection powder for infection treatment (1g)
How to use
intramuscular or intravenous drugs.
Dosage
recommended dose:
Adults: Intramuscular or intravenous intravenous interrupting from 3-6 minutes, 0.5 - 2g/time, 4-6 hours/time or intravenous infusion.
Treatment of bacterial infections or meningitis infections: 8 - 14g or 150 - 200mg/kg, injected many times 3-4 hours apart. For the initial treatment in bacterial infections or meningitis infections must be intravenous for at least 3 days and then it may be intramuscularly.
Children:
Treatment of bacterial infections or meningitis: 100 - 200mg/kg/day divided into small doses 3-4 hours/time, starting with intravenous injection for 3 days and continuing by intramuscular injection.
For bacterial infections in addition to meningitis:
For meningitis in children under 2 months old, venous doses: 100 - 300 mg/kg/day divided into several times in combination with intramuscular gentamicin.
Patients with renal failure:
Creatinine clearance ≥ 30ml/minute: Using conventional doses in adults.
Creatinine clearance ≤ 10ml/min: Using a normal dose every 8 hours/time.
Patients with dialysis must take an additional dose of ampicillin after each time of appraisal.
Treatment time: depends on the type and severity of the infection. For most infections, continue treating at least 48 - 72 hours after the patient is over.
Intramuscularly: Dissolve 1 g ampicillin with 3.5ml of distilled water injected.
Intravenous injection/ intravenous infusion: Dissolve 1g ampicillin with 5 - 10ml of distilled water injected.
The solution has been mixed slowly for at least 3-5 minutes at a dose of 250 - 500mg, at least 10-15 minutes at a dose of 1g. Ampicillin can be added to the injection solution, infusion with appropriate dilution.
Stability and compatibility:
ampicillin is less durable in glucose solution or other carbohydrates. Do not mix ampicillin solution with blood products or hydrolyzed protein solution. Due to the cavalry, the ampicillin should not be mixed in the same container with aminoglycoside.
Ampicillin sodium injection solution must be injected immediately after mixing and not to freeze.
Time to use different diluted solutions for intravenous infusion as follows: diluted solvents Ampicillin concentration Usage time 25oC to 10mg/ml 4 hours 36 hours sodium chloride to 10mg/ml 4 hours 36 hours lactat ringer to 10mg/ml 4 hours 12 hours Note: The above dose is for reference only. Specific dosage depends on the condition and level of progression of the disease. For a suitable dose, you need to consult a doctor or medical specialist. How to handle: Ampicillin can be removed from the general circulation by blood decentralization. In an emergency, call the 115 emergency center immediately or go to the nearest local health station.
4oC
What to do when overdose?
What to do when you forget 1 dose? However, if the time to relax with the next dose is too short, skip the dose and continue the calendar of the drug. Do not use double dose to compensate for missed dose.
Side Effects
Unwanted effects when using ampicilli:
Common: diarrhea, redness (foreign rash).
Uncommon: Anemia, thrombocytopenia, Eosin hypernagus, leukopenia and granulocytosis, tongue inflammation, stomatitis, nausea, vomiting, colitis, fake colitis, diarrhea, urticaria.Rare: Anaphylaxis reactions, flaking dermatitis and diverse erythema. Allergic reactions in the skin like "late ban".
Instructions on how to handle unwanted effects:
If the long -term treatment time, liver and kidney examination must be periodically required.
Must investigate thoroughly to see if the patient has been allergic to penicillin, cephalosporine and other allergies. If the allergic reaction occurs such as: urticaria, anaphylaxis, Stevens Johnson syndrome, it is necessary to immediately stop the ampicillin measure and immediately indicated treatment with epinephrine (adrenaline) and never be treated with penicillin and cephalosporine again.
Notify the doctor the unwanted side effects when using the drug.
Warnings
Before using the drug you need to read the instructions carefully and refer to the information below.
contraindicated
Ampicilli drugs contraindicated in the following cases:
Be cautious when using
Periodic testing of liver and kidney function when long -term treatment.
Cross resistance with cephalosporine.
Patients with renal impairment should be reduced.
Use drugs for women during pregnancy and nursing mothers
Women during pregnancy and nursing mothers can use drugs with normal treatment dose.
The effect of the drug on driving and operating machinery
No data.
Drug interaction
drug interactions may affect the activity of the drug or cause side effects.
Patients should notify the doctor or pharmacist a list of the drugs and functional foods you are using. Do not use or increase or decrease the dose of the drug without the guidance of a doctor.
Storage
Store at room temperature, avoid moisture, avoid light. Do not store in the bathroom. No storage in the freezer. Each drug may have different storage methods. Read carefully storage instructions on the packaging, or ask the pharmacist. Keep pills out of reach of children and pets.
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