Ampicillin 500mg Domesco Treatment Treatment (10 blisters x 10 tablets)

Dosage form Box of 10 blisters x 10 tablets
Specifications Ampicillin
Ingredient Domesco

Ingredient

Composition information	Content
Ampicillin	500mg

Uses

Indications

Ampicillin 500 mg drugs are indicated in the following cases:

Treatment of upper respiratory tract infections caused by Streptococcus Pyogenes, Streptococcus Pneumoniae, Haemophilus Influenzae. Penicillin, often used ampicillin or ampicillin + probenecid (Taking advantage of interactions reduces the elimination of penicillin). And children, often combined with aminoglycosides.

antibacterial spectrum:

Ampicillin is a broad -spectrum antibiotic that works on both gram -positive and gram -negative bacteria: Streptococcus, Pneumococcus and Staphylococcus without penicillinase. However, the effect on the streptococcus beta and pneumococcus is lower than the benzyl penicillin.

Ampicillin also works on meningococcus and gonococcus. Ampicillin works well on some gram -negative bacteria such as E. Coli, Proteus Mirabilis, Shigella, Salmonella. With antibacterial spectroscopy and pharmacokinetic properties, ampicillin is often chosen as a medicine to treat urinary tract infections, cholecystitis and cholangitis.

Ampicillin does not work on some gram -negative bacteria such as: Pseudomonas, Klebsiella, Proteus. Ampicillin also does not work on anaerobic bacteria (bacteroides) causing abscess and infection wounds in the abdominal cavity. In severe bacterial infections from the intestine or vagina, ampicillin is replaced by a combination of clindamycin + aminoglycosides or metronidazol + aminoglycosides or metronidazol + cephalosporin.

pharmacokinetic

absorption

In general, ampicillin trihydrate remains stable when there is the presence of acidic gastric secretions, 30-55 % of oral dose is absorbed through the gastrointestinal tract in adults fasting. The presence of food in the intestinal tract often reduces the speed and absorption level of ampicillin.

Peak concentration in plasma is achieved after 1-2 hours and after taking the dose of 500 mg of peak concentration in the range of 3 - 6 µg/ml.

Distribution

ampicillin is widely allocated and the treatment concentration is achieved in the peritoneal fluid, pleural fluid and joint fluid. The drug is over the placenta and a small amount distributed in breast milk. Ampicillin rarely diffuses through the cerebrospinal fluid, unless the meninges are inflamed.

ampicillin binds to plasma proteins about 20%.

Selling time is about 1 - 1.5 hours but may increase in children less than 1 month old, elderly, kidney failure. In case of severe renal failure, Thai sale time is about 7-20 hours.

Metabolism

ampicillin is converted into penicillonic acid, this substance is eliminated in the urine.

Elimination

Ampicillin's renal excretion occurs partly by glomerular filtration, partly through the excretion of the renal tubules. Probenecid reduces the elimination of ampicillin through the kidney. About 20-40% of oral dose can be excreted in the urine in the form of constant for 6 hours. After taking the dose of 500 mg, the drug concentration in urine is from 0.25 to 1 mg/ml. Ampicillin is eliminated when hemolysis. Ampicillin concentration in high bile, undergoing the gut liver cycle and partly eliminated through feces.

Before taking Ampicillin 500mg Domesco Treatment Treatment (10 blisters x 10 tablets)

How to use

ampicillin 500 mg oral.

Ampicillin dose depends on the type of disease, severity, age and kidney function of the patient. The dose is reduced in severe kidney failure.

Ampicillin 500 mg is usually taken in the form of trihydrates. Food affects the effectiveness of ampicillin. Avoid taking medicine for meals.

Dosage

Adults:

Normal dose of 0.25 g - 1 g of ampicillin/time, every 6 hours, must be taken 30 minutes before meals or 2 hours after meals. With serious illness, can drink 6 - 12 g/day.

To treat uncomplicated gonorrhea due to ampicillin sensitive strains, usually dose 2.0 - 3.5 g, combined with 1 g of probenecid, drink 1 single dose. For women can repeat once if needed.

Children:

This drug is not suitable for children.

People with kidney failure:

Creatinine clearance 30 ml/min or higher: No need to change the usual doses in adults.

Creatinine clearance 10 ml/min or below: Give usual dose every 8 hours/time.

Patients with dialysis must take an additional dose of ampicillin after each appraisal.

Treatment time: depends on the type and severity of the infection. For most infections, except gonorrhea, continue treating at least 48 - 72 hours after the patient is over.

Note: The above dose is for reference only. Specific dosage depends on the condition and level of progression of the disease. For a suitable dose, you need to consult a doctor or medical specialist.

What to do when overdose? In patients with impaired renal function, ampicillin can be removed by hemorrhage without abdominal fertilizer.

What to do when forgetting a dose? Do not take two doses at the same time.

Side Effects

When using ampicillin 500 mg, you may experience unwanted effects (ADR).

Common, ADR> 1/100

Digestive: diarrhea

Blood: Anemia, thrombocytopenia, eosinophilia prefer eosin, leukopenia and granulocytosis.

Systemic body: Anaphylaxis reactions, flaking dermatitis and diverse erythema. If a person with mononulocytosis is treated with ampicillin, 7-12 days after the beginning of treatment, almost 100 % of patients often have very strong red rash. These reactions are also seen in patients with single -blood leukemia caused by cytomegalovirus and lymphocytic leukemia. Single leukemia patients have a good response to other penicillin tolerances (except ampicillin esters such as pivampicillin, bacampicillin).

Notify the doctor with unwanted effects when using the drug.

If the long -term treatment time, liver and kidney examination must be periodically required.

Must investigate carefully to see if patients are allergic to penicillin, cephalosporin and other allergies. If the allergic reaction occurs such as: urticaria, anaphylaxis, Stevens Johnson syndrome, it is necessary to immediately stop the ampicillin measure and immediately indicated treatment with epinephrin (Adrenalin) and never be treated with penicillin and cephalosporin anymore.

Warnings

Before using the drug you need to read the instructions carefully and refer to the information below.

Contraindicated

Ampicillin 500 mg drug is contraindicated in the following cases:

allergies to the Betalactam antibiotic (penicillin and cephalosporin) and other ingredients of the drug.

Be cautious when using

cross allergy with penicillin or cephalosporin. Do not use or absolutely cautious use ampicillin for people who have been sensitive to cephalosporin.

Long treatment time (more than 2-3 weeks) needs to check the liver and kidney function.

The ability to drive and operate machinery

The drug does not affect the ability to drive and operate machinery.

Pregnancy

There are no harmful reactions to the fetus.

Breastfeeding period

ampicillin into milk but does not cause harmful reactions to breastfeed if used in normal treatment dose.

Drug interaction

Penicillin all interact with methotrexate and probenecid. Ampicillin interacts with alopurinol. In patients using ampicillin along with alopurinol, the ability to redness increases.

Pliers antibiotics such as chloramphenicol, tetracyclin, erythromycin reduces ampicillin's bactericidal ability.

There is evidence in vitro of antibacterial antibacterial effects between ampicillin and aminoglycosides against bacterial bacteria; Used to take advantage of treatment in the treatment of endocarditis and other serious intestinal infections.

Aminoglycosid's inactivity has been reported when used with ampicillin in In vitro and in vivo research.

Ampicillin can reduce the effectiveness of contraceptive drugs containing estrogen and significantly increase the bleeding rate.

There is evidence in vitro sulfonamide against ampicillin.

Poral positive reactions can occur in urine glucose tests with clinitest, base solution, fehling solution.

Ampicillin may increase serum uric acid false deviations when using free chelate methods; Phosphotungstate and uricase methods are not affected by ampicillin.

Storage

In a dry place, temperatures below 30 ° C, avoid light.

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