Ampicillin MKP 500 mekophar medicine for infection treatment (10 blisters x 10 tablets)

Dosage form Box of 10 blisters x 10 tablets
Specifications Ampicillin
Ingredient Sinusitis, urinary tract infections, upper respiratory tract

Ingredient

Composition information	Content
Ampicillin	500mg

Uses

Indications

Ampicillin MKP 500 drugs are indicated in the treatment of cases of sensitive bacteria infections, including: ear - nose - throat, bronchitis, pneumonia, gonorrhea, gynecological infections, blood infections, peritonitis, epididitis, meningitis, gastroenteritis.

Pharmacokological

ampicillin is a broad -spectrum antibiotic that works on both Gram -positive and gram -negative bridges: Streptococcus, Pneumococcus and Staphylococcus without penicillinase. Ampicillin also works on masingococcus and gonococcus. Ampicillin works well on some gram -negative bacteria such as E. Coli, Proteus Mirabilis, Shigella, Salmonella. Ampicillin does not work on some Gram -negative bacteria such as: Pseudomonas, Klebsiella, Proteus. Ampicillin also does not work on anaerobic bacteria (bacteroides) causing abscess and infection wounds in the abdominal cavity.

Mechanism of action: Ampicillin impacts the multiplication of bacteria, inhibits the synthesis of mucopeptides into bacterial cell walls.

pharmacokinetic

absorption

When taking 500mg ampicillin, the peak concentration of serum is about 3 mg/liter and reaches about 2 hours after taking the drug. Born is 30 to 55%, the absorption decreases when the stomach has food.

Distribution

About 20% ampicillin binds to plasma proteins. Ampicillin does not pass the blood - brain barrier. In pus meningitis, due to inflammation - brain barrier and permeability change, usually ampicillin penetrates into the central nervous system despite its effectiveness and medium concentration in cerebrospinal fluid reaches 10-35% of the serum concentration. Drugs through the placenta fence.

Metabolism

is partially converted by hydrolyzing β-lactam into penicilloic acid that does not work microbiological.

Elimination

Ampicillin is quickly excreted, 1 hour of sale, mainly through the renal tubules (80%) and bile ducts.

Before taking Ampicillin MKP 500 mekophar medicine for infection treatment (10 blisters x 10 tablets)

How to use

Take 30 minutes before meals - 1 hour or 2 hours after meals.

Dosage

Adults (including the elderly):

Ear - nose - throat infection: 250 mg, 4 times/day.

Bronchitis:

Common dose: 250 mg, 4 times/day.

High dose treatment: 1 g, 4 times/day.

Urinary tract infections: 500mg, 3 times/day.

Gonorrhea: Take the dose of 2 g, combined with 1g of Probenecid, a single dose. The reminders are recommended when treating in women.

Gastrointestinal infections: 500 - 750 mg, 3-4 times/day.

typhoid:

acute: 1 - 2 g, 4 times/day for 2 weeks.

Taking the dose equal to 1/2 adult dose.

In case of severe infections:

Can take a higher dosage than the dose of fish promotion.

In case of severe renal failure (Creatinine clearance

Dose or dosage reduction. For patients with dialysis, one additional dose should be used after each time of appraisal.

Note: The above dose is for reference only. Specific dosage depends on the condition and level of progression of the disease. For a suitable dose, you need to consult a doctor or medical specialist.

What to do when using overdose?

If an overdose occurs, medication must be stopped and used for supportive and symptomatic treatments.

Actively monitor for timely management measures.

What to do when forgetting a dose? Do not take two doses at the same time.

Side Effects

When using Ampicillin MKP 500, you may experience unwanted effects (ADR).

Common, ADR> 1/100

Digestive: diarrhea

Blood: Anemia, thrombocytopenia, eosinophilia loves eosine, leukopenia and loss of granulocytes.

Systemic body: Anaphylaxis reactions, flaking dermatitis and diverse erythema. If a person with mononulocytosis is treated with ampicillin, 7-12 days after the beginning of treatment, almost 100% of patients often have very strong red rash. These reactions are also seen in patients with single -blood cells caused by cytomegalovirus and lymphocytes.

If the long -term treatment time, liver and kidney examination must be periodically required.

Must investigate carefully to see if patients are allergic to penicillin, cephalosporin and other allergies. If the allergic reaction occurs such as: urticaria, anaphylaxis, Stevens-Johnson syndrome, it is necessary to immediately stop the ampicillin therapy and immediately indicated treatment with epinephrine (adrenaline) and never be treated with penicillin and cephalosporins.

Notice immediately to the doctor or pharmacist the harmful reactions encountered when using the drug.

Warnings

Before using the drug you need to read the instructions carefully and refer to the information below.

Contraindicated

Ampicillin MKP 500 medicine is contraindicated in cases of sensitivity to beta-lactam antibiotics (for example, ampicillin, penicillin, cephalosporin) or any ingredients of the drug.

Be cautious when using

cross allergy with penicillin or cephalosporin. Do not use or absolutely cautious use ampicillin for people who have been sensitive to cephalosporin.

Long treatment time (more than 2-3 weeks), need to check the function of liver, kidney and blood.

Avoid using people infected with Epstein-Barr virus and HIV due to the appearance of the erythema.

Patients with renal impairment should be reduced.

The ability to drive and operate machinery

There is no evidence of the effect of the drug on the ability to drive and operate machinery.

Pregnancy

Animal studies with ampicillin does not show a monster effect. When you need to use antibiotics for pregnant women, it is possible to consider using ampicillin.

Breastfeeding period

ampicillin into milk but does not cause harmful reactions for breastfed babies if used in normal treatment.

Medicinal interaction

The drug increases the elimination of uric acid into the urine such as probenecid, sulfinpyrazone: reducing ampicillin secretion, increasing the risk of toxicity.

Simultaneous use of ampicillin and allopurinol: Increases the likelihood of the skin reaction of ampicillin.

Antaginalism: Inr (International Normalized Ratio) may be changed when using ampicillin along with warfarin and phenindione.

Vaccination: The effect of typhoid vaccines can be reduced when used simultaneously with ampicillin.

Anti -cancer drugs: Ampicillin reduces the secretion of methotrexate.

chloroquine: Ampicillin absorption is reduced when used simultaneously with chloroquine.

Pliers antibiotics such as chloramphenicol, tetracycline, erythromycin can hinder the antibacterial activity of ampicillin.

Ampicillin may falsify the results of the glucose test using copper sulfate (such as Benedict, Clinitest).

Storage

Store in a dry place, avoid light, temperature not exceeding 30 ° C.

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