Anbaluti medicine 330mg Oriental treatment of primary and secondary carnitine deficiency (9 blisters x 10 tablets)

Dosage form Film bag tablets
Specifications Box of 9 blisters x 10 tablets
Ingredient Levocarnitine

Ingredient

Composition information	Content
Levocarnitine	330mg

Uses

Indications

Anbaluti drugs are indicated in cases of primary and secondary carnitine deficiency.

Pharmacokological

levocarnitine is a natural active ingredient, essential for energy metabolism in mammals. Levocarnitine has the effect of transporting long fatty acids into the mitochondria, thereby providing substrate for oxidation and energy production. Fatty acids are used as a substrate in all tissues, except for brain tissue. In skeletal and heart muscle, fatty acids are the main substrate in energy production.

pharmacokinetics

Levocarnitine pharmacokinetics information used on adults and forms used on young children is no different.

absorption: Maximum concentration of drugs in plasma is achieved after 3.3 hours of taking the drug.

Distribution: The drug is not linked to protein and plasma albumin.

Metabolism: The drug is metabolized to Tmao and Y-butyrobetaine forms in the digestive tract under the effects of intestinal bacteria. The disposal time of the drug is about 17.4 hours.

Elimination: The drug excreted about 9% in the urine in the form of unprocessed. About 58 - 65% of the drug is metabolized through feces and urine in both metabolized or unprocessed. 76% of the dose is excreted in urine for 0 - 24 hours. The average distribution time of distribution is 0.585 hours and the exhaust time, the last elimination is 17.4 hours on average.

The effect and safety of levocarnitine oral use has not been reported on patients with kidney failure. The use of oral levocarnitine at high doses in patients with severe renal function or end-stage renal disease (ESRD) can lead to the accumulation of toxic metabolites such as Trimethylamine (TMA) and Trimethylamine-N-Oxide (TMAO), because these transformers are often excreted in urine.

There is no special data when comparing the effect of the drug between the elderly patients and other patients, but based on existing data, unwanted effects or other problems may be encountered in the elderly are not different from young adults. Precautions when using drugs in patients with liver disease because there is no complete research data on this object.

Before taking Anbaluti medicine 330mg Oriental treatment of primary and secondary carnitine deficiency (9 blisters x 10 tablets)

How to use

oral.

Dosage

Adults: The recommended dose is 900 mg x 2-3 times/day, adjusting the patient's clinical dose.

infants and young children: dose of 50 - 100 mg/kg/day divided into 2 times, maximum dose is 3g/day. The recommended starting dose is 50 mg/kg/day, then adjust the dose based on the patient's clinical response.

During the use of drugs, monitor the condition of the patient based on hematology parameters.

Note: The above dose is for reference only. Specific dosage depends on the condition and level of progression of the disease. For a suitable dose, you need to consult a doctor or medical specialist.

What to do when using overdose? LD50 of levocarnitine by intravenously on rats is 5.4 g/kg and LD50 of levocarnitine by oral on mice is 19.2 g/kg. The overdose of levocarnitine may cause diarrhea. Levocarnitine has a card removed by dialysis.

What to do when forgetting a dose? If it is nearly time to take the next dose, skip the forgotten dose and take medicine at the next recommended dose. Do not take double dose to compensate for the forgotten dose.

Side Effects

When using Anbaluti, you may experience unwanted effects (ADR).

Common, 1/10> 1/100

Cardiovascular: Hypertension.

digestive: abdominal pain, stomach spasm, diarrhea. nerve: headache, nausea and vomiting.

Uncommon, 1/1000

Cardiovascular: tachycardia.

Systemic: Fever, fatigue, body odor, swelling of the hands, legs and feet, tingling feeling. digestive: abdominal discomfort, reducing taste and weight. nerve: depression, dizziness.

Eye: Reduction of vision.

Rare, ADR

epilepsy.

Instructions on how to handle ADR

In case of patients who have side effects on the digestive system or fatigue: No need to stop the drug because these symptoms will disappear in a short time.

In other cases: stop taking the drug and treat symptoms for patients if necessary.

Warnings

Before using the drug you need to read the instructions carefully and refer to the information below.

Contraindicated

Anbaluti drug is contraindicated in cases of allergies to levocarnitine or any ingredients of the drug.

Precautions when using

The use of levocarnitine for diabetics is treated with insulin or oral hypoglycemic drugs that can lead to blood glucose. Plasma glucose concentrations in these subjects must be monitored regularly to adjust the use of hypoglycemic drugs immediately if necessary. Safety and effectiveness of oral levocarnitine have not been evaluated in patients with renal failure. Using high-dose high-dose levocarnitine in patients with severe kidney functions or in patients with end-stage chronic kidney failure (ESRD) dialysis can lead to toxic metabolic accumulation (Trimethylamine) and TMAO (Trimethylamine-N-Oxide), because these substances are excreted.

There have been reports on increasing the Inr when using the drug along with Coumarin derivatives. Need to follow the INR index in patients using Coumarin derivative while using levocarnitine.

Hypersensitivity reaction:

Severe hypersensitivity reaction, including rash. Hres and facial edema have been reported to oral levocarnitine. Other serious hypersensitivity reactions, including anaphylaxis, larynx edema and bronchospasm, have been reported after levocarnitine intravenous injection, mainly in patients with end -stage renal impairment.

stop using levocarnitine and notify health workers immediately when the symptoms of hypersensitivity reactions begin.

The drug contains lactose. Patients with rare genetic problems in galactose tolerance, lapp lactase or absorbent enzyme lack of glucose galactose should not use this drug.

The ability to drive and operate machinery

No information.

Pregnancy

levocarnitine is not toxic to the fetus or teratogenic in test animals. However, there is no data on the safety of the drug during pregnancy. Therefore, only recommendations for drug use during pregnancy if the benefits are higher than the risk.

Breastfeeding period

There is no levocarnitine data excreted through breast milk. Research on cows shows that the level of levocarnitine increases in cow's milk after being injected. Therefore, it is necessary to mention the risk of levocarnitine milk on babies with the benefits of adding levocarnitine to the mother. Should be cautious when taking medicine for this object. During pregnancy should consult a doctor or pharmacist before taking the drug.

Medicinal interaction

The drug may increase the effects of anticoagulants (such as warfarin).

Storage

In a cool dry place, avoid light, the temperature does not exceed 30 ° C.

Other drugs

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