Andriol Testocaps 40mg Catalent supports the treatment of male gonads (3 blisters x 10 tablets)

Dosage form Box of 3 blisters x 10 tablets
Specifications Testosterone
Ingredient Catalent

Ingredient

Composition information	Content
Testosterone	40mg

Uses

indications

Andriol Testocaps 40 mg is indicated in the following cases:

Testosterone replacement therapy in men due to primary or secondary gonads, congenital or suffering. This treatment also increases the concentration of dihydrotestosterone (DHT) and Estradiol (E2) in plasma, as well as reducing globulin associated with sex hormones (SHBG), hormones creating royal (LH) and follic stimulating hormones (FSH). Treatment with Andriol Testocaps has results improving the symptoms due to testosterone deficiency in both young and elderly male patients with genital defects.

Moreover, this treatment also increases the mineral density in bones and muscle mass in the body and reduces the fat mass of the body. The treatment also improves genital function, including desire and erection function. Dosage depends on LDL - C, HDL - C and Triglycerides in plasma, increased hemoglobin and hematocrit, does not change the liver enzymes and PSA related to clinical. This treatment may cause an increase in prostate size, but there is no adverse effects on the prostate.

In patients with sexual diabetes, it has recorded an increase in insulin and/or reducing blood glucose. In boys who are physically retarded and puberty, treatment with Andriol Testocaps first promotes growth and then causes the development of secondary sexual properties. In women who cut the ovaries only treated with estrogen, add Andriol Testocaps will improve the libido and increase the mineral density in the bones and muscle mass of the body. In people who switch sex from female to male, treat Andriol Testocaps causes masculinization.

Pharmacokinetics

absorption

After taking Andriol Testocaps, a large part of the active ingredient is Testosterone Undecanoat absorbed along with fat -loving solvents from the digestive tract into the lymphatic system, avoiding some initial inactivity in the liver. Andriol Testocaps must be taken at a normal meal or breakfast to ensure good absorption. Birth is about 7%.

Distribution

From the lymphatic system testosterone undecanoat is released into plasma and hydrolyzed into testosterone.

The only dose Andriol Testocaps 80 - 160 mg significantly increases the total amount of testosterone in plasma with a peak concentration of about 40 nmol/l (cmax), reaching about 4-5 hours (TMAX) after oral. Testosterone levels in plasma still maintain high concentration for at least 8 hours.

Testosterone and testosterone undecanoat are highly linked (over 97%) but not specific to plasma proteins and binding to sexual hormone globulin in in vitro tests.

Metabolism

In plasma and tissues, the UNDECANOAT testosterone is hydrolyzed into natural male androgen testosterone. Testosterone is transformed into dihydrotestosterone and estradiol.

Elimination

Testosterone, Estradiol and Dihydrotestosterone are metabolized through the normal metabolic path. The excretion mainly in urine in the form of conjugated by etiocholanolon and Androsteron.

linear: proven linear with the dose when used within 40 - 240 mg/day.

Before taking Andriol Testocaps 40mg Catalent supports the treatment of male gonads (3 blisters x 10 tablets)

How to use

to ensure good absorption, drink Andriol Testocaps at meals, if necessary, with a little water and swallow the pill. It is best to take half the dose in the morning and the other half of the dose to drink in the evening.

Dosage

Adults: The starting dose is usually 120 - 160 mg/day, for 2-3 weeks. The next dose (40 - 120 mg/day) should be based on clinical effects achieved after the first weeks of treatment.

Children: Not determined safety and efficiency in children.

generally should adjust the dose according to the response of each patient.

Note: The above dose is for reference only. Specific dosage depends on the condition and level of progression of the disease. For a suitable dose, you need to consult a doctor or medical specialist.

What to do when overdose?

Testosterone toxicity is low.

Andriol testocaps overdose can cause discomfort in the digestive tract due to castor oil; Support treatment when overdose.

What to do when you forget a dose? However, if close to the next dose, skip the forgotten dose and take the next dose at the time as planned. Do not drink twice as prescribed.

Side Effects

When using Andriol Testrocaps 40 mg, you may experience unwanted effects (ADR).

Prostate cancer.

Blood and lymphatic system: Red blood cell disease.

Metabolism: Keep water. Neurological: depression, stress, temperament disorders, increase/decrease of libido.

Muscle muscle: muscle pain.

Cardiovascular: Hypertension. digestive: nausea. skin: itching, acne.

Reproduction system: Big breast in men, reduce sperm, erectile, prostate disease.

Testing: Extraordinary test of liver function, blood lipid, increased PSA.

Instructions on how to handle ADR

When experiencing side effects of the drug, it is necessary to stop using and notify the doctor or go to the nearest medical facility for timely treatment.

Warnings

Before using the drug you need to read the instructions carefully and refer to the information below.

Contraindicated

Andriol Testocaps 40 mg contraindicated in the following cases:

Pre -history or currently prostate cancer or breast cancer.

Patients with a history of liver tumor.

Hypersensitivity to drugs or any excipients of the drug.

Be cautious when using

Before starting the medication, the doctor should consider to check the following parameters each quarter for the first 12 months and each year for patients to use Andriol Testocaps:

Prostate examination by hand through the rectum and PSA.

hematocrit and hemoglobin to eliminate red blood cells.

Patients with previous heart, kidney or liver disease, androgen treatment may cause complications shown by edema with or without congestion. In these cases, it must be stopped immediately.

Patients who have had myocardial infarction, heart failure, liver, kidney, hypertension, epilepsy or migraine should be monitored due to the risk of deteriorating or recurrent disease. In these cases, stop treatment immediately.

Androgen in general and Andriol Testocaps may improve glucose intake in diabetes patients and anticoagulant effects.

There is no appropriate evidence of the use of testosterone esterification safely for men to be apnea. Clinical assessment should be closely and cautious when used for people with risk factors such as obesity or chronic lung disease.

Should closely monitor growth and education in boys who have not puberty due to overall andriol testocaps of high doses can promote the process of bone cartilage and mature.

If the adverse reactions appear due to androgen use, Andriol Testocaps should be discontinued and/or re -used at lower doses.

Andriol Testrocaps contains orange yellow (Sunset Yellow (E110, FD & C Yellow No. 6) can cause allergic reactions.

The ability to drive and operate machinery

so far has not recorded Andriol Testocaps has affected the vigilance and concentration.

pregnancy

There is no appropriate data on the use of Andriol Testocaps in pregnant women. Regarding the risk of masculating fetus, Andriol Testocaps should not be used during pregnancy. Andriol Testocaps should be stopped if pregnant.

Lactation period

There is no appropriate data on the use of Andriol Testocaps during breastfeeding. Therefore, Andriol Testocaps should therefore be used during breastfeeding.

Drug interaction

Enzyme induction agents can reduce testosterone levels and enzyme inhibitors that can increase testosterone levels; Therefore may need to adjust Andriol Testocaps.

Androgen can improve glucose tolerance and reduce insulin use needs or other diabetes treatments.

Androgen can increase the anticoagulant effects of cooumarin drugs, so it is necessary to reduce the dose of these drugs.

Must take Andriol Testocaps at meals to ensure drug absorption.

Testosterone simultaneous use with ACTH or corticosteroids may increase edematous phenomenon, so use these activity substances carefully, especially in patients with heart disease or liver disease or in patients at risk of edema.

Interaction affects test results

Androgen may reduce the level of globulin -linked thyroxin, resulting in reducing the total serum T4 and increasing the absorption of T3 and T4. The level of free thyroid hormone does not change, however, there is no clinical evidence of thyroid dysfunction.

Storage

less than 30 ° C, not in the refrigerator or frozen. Store in the original packaging and hold the medicine in the carton box.

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