Angioten medicine 50mg kalbe to treat hypertension (3 blisters x 10 tablets)

Dosage form Box of 3 blisters x 10 tablets
Specifications Losartan
Ingredient High blood pressure

Ingredient

Composition information	Content
Losartan	50mg

Uses

indicated

angioten is indicated in cases of hypertension.

Pharmacokological

Angioten (Losartan Potassium) is the first substance belonging to the new group of antihypertensive drugs, an antagonistic substance with Angiotensin II receptor not peptid. This new active ingredient combines competition and selection with AII's group receptors (AT1 receptors) so it prevents AII's pharmacological effects, active metabolites, E3174, capable of connecting with AT1 receptors 10 times larger than the original substance with the same structure, and has a higher effect of 15 to 20 times in preventing AII's pharmacological effects, causing spinkers of the bloodstream and causing blood pressure.

angioten works when used by oral. For patients with hypertension, the use of Angioten once a day will hypotension for 24 hours without affecting the heart rate. The monatlearads with a dose of 50 to 100 mg Losartan Potassium daily will reduce diastolic blood pressure (DBP) from 8 to 13 mmHg in patients with hypertension mild to moderate and show that it has the same effect as enalapril, Atenolol or Felodipine. Using Losartan combination with diuretics will have more hypotension effect when using losartan alone.

pharmacokinetics

Losartan is an orally active preparation and it undergo the first main metabolism thanks to the 450 cytochrome enzyme system. The half -life of Losartan is about 2 hours and of the metabolites at about 6 to 9 hours.

The pharmacokinetics of Losartan and its metabolites are close to the oral dosage of Losartan of 200 mg and does not change over time. There is no accumulation of both Losartan or the metabolite in plasma right after repeating at a dose once a day.

After drinking, Losartan is quickly absorbed through the gastrointestinal tract (based on the absorption of Losartan with radioactive bonds) and mainly involved in the first metabolism process, the whole bioavailability of Losartan is 33%. About 14% of the losartan taken into transformed into active metabolic form.

The average peak concentration in Losartan's plasma is achieved after 1 hour and its metabolites are achieved after 3-4 hours. While Losartan's peaked plasma concentration and its metabolites are approximately equal, the curve area below the AUC concentration of the metabolitus is larger than Losartan up to 4 times. The food slows down the absorption of Losartan and reduces its maximum concentration in the serum but only affects the area under the concentration curve of Losartan and metabolites (down about 10%).

The ratio of cohesion with plasma proteins of both Losartan and the metabolites are very high, mainly with albumin, the free form of plasma is 1.3% and 0.2%. The amount associated with protein is constant within the concentration limit when used for normal doses. Mouse studies show that only a small amount of Losartan and its metabolites through the bloody barrier.

Losartan's metabolites are present in both serum and urine of humans. In addition to the metabolites with carboxylic activity, there is also one in the form of non -activity metabolites. After drinking and intravenous losartan intravenously, there is a 14C radio isotope, the radioactive substance has the main circulating activity in plasma, Losartan and its metabolites.

Studies in Invitro shows that Cytochrome P450 2C9 and 3A4 are related to Losartan's biological transformation and its metabolites. A small amount of Losartan converted into an active metabolic substance (less than 1% of oral doses compared to 14% of the dose in normal cases) in about 1% of the research cases. The distribution of Losartan's body is 34 L and of the metabolic substance is 12 L.

Losartan's total plasma clearance and its metabolites are about 600 ml/min and 50 ml/min, and the renal clearance is 75 ml/min and 25ml/min. When taking Losartan, there are about 4% of the oral medication in the form of unprocessed and 6% in the form of metabolites that are active in the urine. The secret secretion also participates in the process of Losartan's export and its metabolites. After an intravenous injection of 14C Losartan, about 45% of radioactive substances are restored from the urine and 50% from the stool.

Before taking Angioten medicine 50mg kalbe to treat hypertension (3 blisters x 10 tablets)

How to use

can drink angioten during or outside the meal. Angioten can be used simultaneously with other hypotension preparations.

Dosage

For patients with idiopathic hypertension: The starting and maintenance dose is 50 mg of Losartan once a day. There are some patients may have to use up to 100 mg of Losartan daily to respond.

For patients with liver function or a decrease in circulatory volume or patients at risk of hypotension, lower doses should be used by 25 mg of Losartan daily.

No need to adjust the starting dose for older patients or patients with renal function, including patients with dialysis. Losartan and its metabolites are not removed by dialysis.

Note: The above dose is for reference only. Specific dosage depends on the condition and level of progression of the disease. For a suitable dose, you need to consult a doctor or medical specialist.What to do when overdose? The data overdose of Losartan overdose is limited. The most common manifestation of overdose is hypotension and fast heartbeat; Slow heart rate can occur due to sympathetic stimulation. If hypotension occurs, it is necessary to apply supportive treatment. Both Losartan and its metabolites are not removed by dialysis.

What to do when you forget a dose? However, if close to the next dose, skip the forgotten dose and take the next dose at the time as planned. Note that it should not be used double the prescribed dose.

Side Effects

When using Angioten you may experience some unwanted effects (ADR).

Unwanted effects include: dizziness, dizziness, headache, fatigue, cough, diarrhea, shortness of breath, muscle spasms (cramps), muscle pain, back pain, foot pain, insomnia, nasal congestion, upper respiratory infection, abnormalities and severe sinusitis.

These adultery effects are related or not related to the treatment that occurs at least 1% of the total patient.

History direction when meeting ADR

Notify the doctor for side effects encountered during treatment.

Warnings

Contraindicated

Do not use angioten for patients with a history of allergies to Losartan or any component of the drug.

Be cautious when using

may experience systemic blood pressure in patients who reduce intravascular volume, so the startan starts with low doses.

For patients with renal function and older patients, they should regularly check the amount of potassium in the blood.

Patients with liver function impairment: Losartan concentration and its metabolic substance in serum may increase, so it is necessary to adjust Angioten's dosage to these patients.

Safety and effectiveness of Losartan for children has not been proven.

The ability to drive and operate machinery

There has been no report on the effect of drugs on driving and operating machinery.

Pregnancy

Do not use angioten for pregnant women because it may be at risk of causing pathological conditions for the fetus and death.

The period of breastfeeding

It is not known whether Losartan will be allowed to be exported into breast milk. Should decide whether to stop breastfeeding or stop using Angioten is based on the importance of medication for mothers.

Interactive drug

Thiazid diuretics: If using simultaneously Losartan with thiazid diuretics, the effect of lowering blood pressure will increase.

Not used simultaneously Angioten with potassium diuretic drugs.

Storage

Store at room temperature, below 30 ° C

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