Angut medicine 300mg DHG reduces the formation of uric acid, treating kidney stones (10 blisters x 10 tablets)

Dosage form Box of 10 blisters x 10 tablets
Specifications Allopurinol
Ingredient Kidney stones, gout, arthritis

Ingredient

Composition information	Content
Allopurinol	300mg

Uses

Indications

Angut medicine indicated treatment in the following cases:

Reduce urate/uric acid formation in diseases that cause urate/uric acid deposition (such as gout arthritis, urate in the skin, kidney stones) or clinical risks that can be predicted (such as the treatment of malignant tumors that can lead to acute kidney disease caused by uric acid). The active deficiency of adenin phosphoribosyltransferase. Allopurinol and main metabolites of oxipurinol reduces uric acid levels in plasma and urine by inhibiting xanthin oxidase, enzymes that catalyze the oxidation of hypoxanthin into xanthin and xanthin into uric acid. In addition, the drug also inhibits purine catalosis in some patients with hyperuricemia, once again reducing purin biosynthesis through the mechanism of reverse inhibiting hypoxanthin - guanin phosphoribosyltranferase. Other metabolites of allopurinol include allopurinol - ribosid and oxipurinol - 7 ribosid.

pharmacokinetic

Allopurinol is quickly absorbed through the gastrointestinal tract. Born is estimated to change from 67% - 90%. The peak concentration of Allopurinol usually appears about 1.5 hours after drinking, but decreases rapidly and is almost impossible to detect after 6 hours. The peak concentration of oxipurinol usually appears after 3-5 hours after drinking. Allopurinol waste time is about 1-2 hours. About 20% Allopurinol oral dosage is eliminated through feces.

Oxipurinol is eliminated in the form of unchanged urine, but there are half -life eliminated for a long time because it is reabsorbed in the renal tubules. Half -life is sold from 13.6 hours to 29 hours.

Before taking Angut medicine 300mg DHG reduces the formation of uric acid, treating kidney stones (10 blisters x 10 tablets)

How to use

Angut tablets for oral tablets.

Dosage

angut 300 mg can be used once a day after meals. The drug is well tolerated, especially after eating. The daily dose should not exceed 300 mg and when there is a tolerance through the gastrointestinal tract can be divided into appropriate doses.

Adults: Allopurinol should be used at low doses such as 100mg/day to reduce the risk of adverse reactions and increase if Urat's serum reactions are unsatisfactory.

The recommended dosage modes are as follows:

Case of mild disease: Do not use this product due to difficult dose.

Case of average disease: 300 - 600 mg per day.

Severe illness: 700 - 900 mg per day.

Dosage based on body weight: 2 - 10 mg/kg/day.

Children: Children under 15 years: 10 - 20 mg/kg/day to a maximum dose of 400 mg/day. Rarely indicates children unless malignant disease (especially leukemia) and a few yeast disorders such as Lesch - Nyhan syndrome.

Elderly: In the absence of specific data, the lowest dose should be used to reduce Urat satisfactory.

Hepatic failure: Dosage should be reduced in patients with liver failure. Recommended testing of liver function in the early stages of therapy.

Renal failure: Because Allopurinol and its metabolites are eliminated through the kidneys, the renal function may lead to drug storage and/ or its metabolites with a semi -discharged time in the corresponding plasma. In case of severe renal failure, the dose of less than 100 mg should be used daily or using a single dose of 100 mg at a distance of more than 1 day.

Treatment of high urate levels such as cancer, lesch - NYHAN syndrome: Should adjust the condition of hyperuricemia or urinaryuria increased with allopurinol before starting cytotoxic therapy. It is important to ensure adequate drinking of water to maintain maximum urology and alkaline urine to increase the solubility of urate/ uric acid in urine. Allopurinol should start at lower doses than the recommended dose. If kidney disease is caused by urate or other pathologies that damage kidney function, allopurinol should be used according to the dose instructions in the case of renal failure.

Note: The above dose is for reference only. Specific dosage depends on the condition and level of progression of the disease. For a suitable dose, you need to consult a doctor or medical specialist.

What to do when overdose? Symptoms and signs including nausea, vomiting, diarrhea, dizziness have been reported in patients using 20 g of allurinol.

Normal support measures can help recover. Excessive absorption of allopurinol can lead to significant inhibition of xanthin oxidase activity without adverse effects except affecting the medication simultaneously, especially with 6-mercaptopurin and/ or azathioprin.

Drink adequate water to maintain maximum urology to facilitate the excretion of Allopurinol and its metabolites. Hematopathy can be absorbed if necessary.

In an emergency, call the 115 emergency center immediately or go to the nearest local health station.

What to do when forgetting 1 dose? However, if the time to relax with the next dose is too short, skip the dose and continue the calendar of the drug. Do not use double dose to compensate for missed dose.

Side Effects

Allopurinol's most common side effects are skin rashes. The rash is usually lumpy or itchy, sometimes the hemorrhage, but the more dangerous hypersensitivity reaction may occur, including the flaking rash, the Stevens - Johnson syndrome and the toxic epidermal necrosis. Therefore, stop using the drug as soon as the rash appears. Other symptoms of hypersensitivity include fever and chills, lymph nodes, leukopenia or leukemia, acidic hyperbears, joint pain and vasculitis leading to kidney and liver damage, very rare epilepsy. These hypersensitivity reactions may be severe, even death and liver failure or kidney failure. Liver toxicity and signs of liver function change can also be seen in patients who do not show hypersensitivity. Hematology effects include plateletal reduction, hyperplasmic anemia, granulocytosis and hemolytic anemia.

Common, ADR> 1/100

Skin reactions: rash, lumpy, itching, flaking dermatitis, urticaria, erythema, eczema, hemorrhage.

Liver: Increasing alkaline phosphatase, AST, ALT, Liver to recover, destroy liver cells, hepatitis, liver failure, increase blood bilirubin, jaundice.

Systemic body: heavy hypersensitivity reaction, fever, chills, sweating, discomfort, peeling nails, flat, face edema, skin edema, hair loss, nosebleeds. Blood.

Neurological: peripheral neuropathy, neuritis, paresthesia, headache, seizures, epilepsy, muscle jerky, reducing tone, agitation, changing mental status, cerebral infarction, coma, muscle disorders, paralysis, tremor, chicken sleep, dizziness, depression, confusion, sleeping eyes, weakness.

urinary: kidney failure.

Warnings

Before using the drug you need to read the instructions carefully and refer to the information below.

Contraindicated

Angut drugs contraindicated in the following cases:

Hypersensitivity to Allopurinol or with the ingredients of the drug.

Caution when using

should stop using allopurinol when there is a skin rash or have other signs of sensitivity, as these signs can lead to more serious hypersensitivity reactions (including Stevens - Johnson (SJS) syndrome, toxic epidermal necrosis (ten)) and hypersensitivity syndrome.

Patients with chronic renal failure and are using diuretics, especially thiazid, may increase the risk of developing hypersensitivity reactions including SJS / Ten when using allopurinol.

Should reduce the dose in patients with liver or renal failure. Patients who are treating hypertension or heart failure, such as diuretics or enzyme inhibitors, may be accompanied by kidney failure, should use Allopurinol.

Often indicates that Allopurinol treats asymptomatic hyperuricemia. The change of diet combined with the treatment of the cause can improve the disease.

Acute gout attacks should not start treatment with allopurinol until acute gout attacks completely because it can cause worse gout attacks.

In the early stages of treatment with allopurinol, as well as with urinary urinary drugs, it can cause acute gout arthritis. Therefore, it is advisable to prevent appropriate anti -inflammatory drugs or colchicin at least a month.

If acute gout attacks in patients who are using allopurinol, should continue treatment at the same dose and acute gout attacks treated with an appropriate anti -inflammatory drug.

Xanthin deposits: In the disease, there is an increase in urate formation rate (such as malignant disease and the treatment of malignant disease, Lesch - NYHAN syndrome) The absolute concentration of xanthin in urine can increase, in rare, sufficient cases to cause deposition in the urinary road. This risk can be minimized by drinking enough water to dilute the best urine.

The obstruction of the uric acid stones in the kidneys: appropriate treatment for allopurinol will lead to the solubility of large uric acid stones in the renal pelvis, the ability to block the ureter is less likely to occur.

Using drugs for women during pregnancy and lactation

There is no full evidence of Allopurinol's safety in pregnant women, although the drug has been widely used for many years without any obvious bad consequences. Only use drugs in pregnant women when there is no safer replacement and when the disease itself brings risks to the mother or fetus.

Reports to identify Allopurinol and oxipurinol are excreted into breast milk. However, there is no information related to the influence of Allopurinol or its metabolites on breastfeeding.

The effect of the drug on the ability to drive and operate machinery

side effects such as drowsiness, dizziness and loss of air conditioning have been reported in patients with allopurinol, patients should take care of the drug before driving, operate machinery or participate in dangerous activities until it is sure that Allopurinol does not cause any adverse effects.

Medicinal interaction

anticoagulant drugs Coumarin: may increase the efficiency of warfarin and other anticoagulants in some cases.

Azathioprin or 6 - Mercaptopurin: Used in combination with Allopurinol should reduce ¼ doses of Azathioprin or 6 - Mercaptopurin compared to conventional doses because the Xanthin oxidase inhibitors will extend the time time.

vidarabin (adenin arabinosid): Vidarabin's waste sale time is increased when coordinated.

Uricura -active drugs such as sulfinpyrazon, probenecid or high doses of salicylate reduces allurinol's therapeutic effect because these drugs increase oxipurinol excretion more.

Clorpropamid: Used in combination, causing an increase in the risk of prolonged hypoglycemia when kidney failure.

Theophylin: The excretion of these drugs is inhibited by allopurinol, which may be due to the inhibition of oxidase xanthin.

ampicillin/ amoxicillin: may increase the risk of skin reactions.

cyclosporin: plasma concentration of cyclosporin increases, so it can increase toxicity.

Phenytoin: Allopurinol may inhibit phenytoin oxidation but the clinical significance has not been proven.

Didanosin: Combining two drugs simultaneously not recommended. If coordinated is inevitable, the dosamosin should be reduced by the patient should be closely monitored.

cyclophosphamide, doxorubicin, bheomycin, processbazin, mechloroethamine: cyclophosphamide or other cytotoxic toxic agents that increase bone inhibition in patients with tumor (different from leukemia) when using Allopurinol. However, in a controlled study, patients treated with cyclophosphamid, doxorubicin, bheomycin, processbazin and/or mechloroethamine (Mechlorethamine hydrochloride) Allopurinol does not increase the toxic reaction of toxic drugs.

Storage

In a dry place, the temperature does not exceed 30 ° C, avoiding light.

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