Ankodinir dopharma oral powder for mild to medium infection

Dosage form Box
Specifications Cefdinir
Ingredient Central Pharmaceutical Joint Stock Company 2

Ingredient

Thành phần cho 5ml

Composition information	Content
Cefdinir	250mg

Uses

Indications

used to treat mild to moderate infections, caused by sensitive bacterial strains:

adults and adolescents:

Having pneumonia in the haemophilus influenzae community (including ß-lactamase strain), Haemophilus parainfluenzae (including ß-lactamase strain), Streptococcus pneumoniae (indicating strains sensitive to penicillin), and Moraxella Catacrhalis (including secretions in secretions ß-lactamase).

The acute inflammation of chronic bronchitis: due to Haemophilus influenzae (including ß-lactamase strain), Haemophilus parainfluenzae (including ß-lactamase strains), Streptococcus pneumoniae (only sensitive strains with penicillin), and Moraxella Catatrhalis (including strain ß-lactamase).

Haemophilus Influenzae sinusitis (including ß-lactamase strains), Streptococcus pneumoniae (only sensitive strains with penicillin), and Moraxella CatVhalis (including ß-lactamase secretion).

Sore throat/tonsillitis: due to streptococcus pyogenes.

Skin infections and uncomplicated skin structure caused by Staphylococcus aureus (including ß-lactamase strain) and Streptococcus pyogenes.

Children:

Acute otitis media caused by Haemophilus Influenzae (including ß-lactamase strains), Streptococcus pneumoniae (only sensitive strains of penicillin), and Moraxella Catatrhalis (including ß-lactamase secretion).

Sore throat/tonsillitis: due to streptococcus pyogenes.

Skin infections and uncomplicated skin structure caused by Staphylococcus aureus (including ß-lactamase strain) and Streptococcus pyogenes.

Pharmacology

Pharmacological group: Cephalosporin antibiotic 3rd generation.

ATC code: J01DD15. Cefdinir is a 3rd generation cephalosporin antibiotic, the drug has a spectrum of anti -resistant to many Gram -negative and gram -positive bacteria. Cefdinir has bactericidal effects due to synthetic inhibition of bacterial cell walls.

cefdinir works on most bacteria strains such as:

Gram (+) bacteria:

Staphylococcus aureus (only sensitive strains with methicillin).

Haemophilus Influenzae.

Haemophilus parainfluenzae. Penicillin resistance and staphylococcus anti -methicillin staphylococcus, ampicillin -resistant H.influenzae strains are often not sensitive to cefdinir.

pharmacokinetics

cefdinir is absorbed through the gastrointestinal tract after drinking, the peak concentration in plasma is achieved after 2-4 hours of drinking. Oral bioavailability is about 16-25%. The drug is widely distributed into the tissue, about 60-70% linked to plasma proteins. Cefdinir metabolizes negligible and eliminated through urine, the semi -waste time of the drug is about 1.7 hours. Cefdinir is eliminated by hemorrhage.

Before taking Ankodinir dopharma oral powder for mild to medium infection

How to use

How to use:

Used orally. Use filtered water or boiled water to cool.

How to make the drug into oral fluid:

concentration after mixing or boiled water to cool. Each time add water tightly, shake well until forming a homogeneous mixture. The total amount of added water is 37.5 ml is divided into 2-3 add water to the jar, using filtered water or boiled water to cool. Each time add water tightly, shake well until forming a homogeneous mixture. The total amount of added water is 62.5 ml is divided into 2-3 times to add water to the jar, use filtered water or boiled water to cool. Each time add water tightly, shake well until forming a homogeneous mixture. The vials must be closed and before each use of the pills must be shaky to create a homogeneous mixture to use the drug. The phase phase may be used within 10 days, after 10 days, no excess drugs are used.

Dosage

Adults and adolescents:

Pneumonia is suffering from the community: 300 mg/time x 2 times/day, for 10 days. or 600 mg/time x 1 time/day, for 10 days.

otitis media: 7mg/kg/time x 2 times/day or 14mg/kg/time/day, 10 days. or 14mg/kg/time/day for 10 days.

Weight (kg) Dosage (250mg/5ml) > 27 3.75ml/12 hours or 7.5ml/24 hours Weight ≥ 43 kg can use a maximum dose of 600 mg daily.

Patients with renal failure:

For adult patients with creatinine clearance For patients with creatinine clearance

Patients with dialysis:

Hemodialysis will remove Cefdinir from the body. In patients with chronic dialysis, the initial dosage is recommended for 300 mg or 7 mg/kg on no dialysis days. On hemodialysis days, the dose is 300 mg (or 7 mg/kg), used at the end of each dialysis session.

What do

do when using overdose?

Symptoms of overdose of cephalosporin antibiotics such as nausea, vomiting, epigastric pain, diarrhea, convulsions, ...

Treatment: Treatment of symptoms and eliminating drugs out of the body. Hematopathy can be carried out to prevent the drug from the blood.

What to do when forgetting a dose?

Side Effects

ADR> = 1/100:

Diabamia, nausea, headache, vaginitis, abdominal pain.

1/1000

Red rash, bloating, indigestion, vomiting, constipation, anorexia, dizziness, dry mouth, weakness, insomnia, dreaming.

Warnings

Before using the drug you need to read the instructions carefully and refer to the information below.

Contraindicated

History of allergies to cefdinir and antibiotics of cephalosporin or any ingredients of the drug.

Be cautious when using

Antibiotic indications when there is no doubt infection or bacterial infection, prophylaxis may increase the risk of developing anti -drug organisms.

Similar to other wide spectrum antibiotics that can lead to anti -drug development and development. Monitoring infection is necessary, if infections occur during treatment may need other alternative treatments.

cefdinir should be carefully indicated in people with a history of colitis.

Personal history or family allergic: urticaria, rash, bronchial asthma.

Patients with severe renal failure, elderly, exhaustion.

Diabetes patients need to be cautious because the oral mixture contains sugar.

Patients with genetic factors in fructose tolerance, or malposive glucose-galactose, or deficiency of sucrase-isomaltase should not be used.

The effect of the drug on driving and operating machinery

There is no evidence of the effect of the drug on the ability to drive and operate machinery.

Use drugs for women during pregnancy and lactation

Pregnant women:

There is no complete research on pregnant women. Only use the drug when really necessary.

breastfeeding women:

After using a single dose of 600mg, Cefdinir is not detected in breast milk.

Drug interaction

The impact of other drugs from cefdinir:

iron -containing foods affect the absorption of cefdinir. It is necessary to drink before or after cefdinir 2 hours. With iron supplements (containing 2.2 mg of elemental iron) does not significantly affect the pharmacokinetics of CEFDinir, so Cefdinir can be taken with these formulas.

Probenecid: reduces the excretion of cefdinir through the kidney.

Anti -acid drugs (containing aluminum and magnesium): Use Cefdinir at least 2 hours before or after taking antacids.

affects the test:

Using Cefdinir can create fake positive results in ceton tests in biography Nitroprusside reagent.

Using Cefdinir can also create a false positive result with glucose test in biography of clinitest, Benedict solution, fehling solution.

Cephalosporin antibiotics are also reported to produce fake Coombs test results.

Storage

In a dry place, temperatures below 30 ° C, avoid light.

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