Antivic 75 An Thien medicine treats central and peripheral neuropathy (10 blisters x 10 tablets)

Dosage form Box of 10 blisters x 10 tablets
Specifications Pregabalin
Ingredient An Thien Pharmaceutical Joint Stock Company - Vietnam

Ingredient

Composition information	Content
Pregabalin	75mg

Uses

Indications

Antivic 75 mg drug is indicated in the following cases:

Central and peripheral neuropathy treatment: Treatment of prolonged pain caused by damage to nerves. Many diseases can cause peripheral neuropathy, such as diabetes or shingles. The pain can be described as hot, burning, throbbing, shooting, stabbing, sharp, cramps, soreness, tingling, numbness, needle. Peripheral and central nerve pain may also be related to changes in mood, sleep disorders, fatigue and can affect physical, social and overall life quality. The doctor will prescribe antivic drugs 75 mg for patients to support the treatment of epilepsy when treating the current treatment without controlling the condition. Antivic 75 mg is not used alone, must always be used in combination with other anti -epileptic drugs. GAD symptoms are excessive anxiety and difficult to control. GAD can also cause restlessness or feel tired, easy to focus or empty mind, feel irritable, muscle tension or disturbing sleep.

Pregabalin is an anti -convulsed and analgesic drug. Pregabalin has a structure similar to the central neurological inhibitor GABA, but is not directly attached to the Gabaa, GABAB, or Benzodiazepine receptors, does not increase GABAA's response on cultured neurons, nor does it change GABA levels in the mouse brain, does not affect GABA recovery as well as gaba. On cultured neurons, long -term use of pregabalin will increase the density of transport proteins and increase GABA shipping speed.

Pregabalin is attached to central nervous tissues with high affinity at the position of α2- Although Pregabalin's exact mechanism is not fully known, the attachment to subunit α2-S may be related to pregabalin analgesic and anti-convulsions effects. In vitro, Pregabalin reduces the release of calcium -dependent neurotransmitters such as glutamat, norepinephrin, peptides related to calcitonin regulating genes, and P substances, can be through the function of the calcium channel.

Mechanism of action:

Pregabalin is attached to a sub -unit (α2– Δ protein) of the voltage calcium channel in the central nervous system.

Evidence from a nervous animal model indicates that pregabalin release neurotransmitters that perceive pain depends on the calcium in the spinal cord, which can be through the blocking of calcium transport and/or decrease in calcium. Evidence from other animal models with nerve damage shows that pregabalin analgesic activity can also be indirectly through interactions with sympathetic and serotonin.

pharmacokinetic

absorption:

Antivic 75 mg is quickly absorbed at oral, the peak concentration in plasma is achieved after about 1 - 1.5 hours. Clinically, the effect of food is negligible due to reducing speed, not reducing the level of drug absorption. Oral bioavailability of the active ingredient is ≥ 90%, regardless of the dose. Stable concentration achieved after drinking 24 - 48 hours.

Distribution:

In humans, the distribution of pregabalin after drinking is about 0.56L/kg. Pregabalin is not linked to plasma proteins.

Metabolism:

In the human body the metabolism of pregabalin is negligible. Pregabalin's main metabolites found in urine account for only 0.9% of the dose.

Era:

Pregabalin is eliminated from the circulatory system mainly by excreting through the kidney in the form of unchanged drugs. The average disposal time of pregabalin is 6.3 hours. The clearance of pregabalin in plasma and renal clearance is proportional to the clearine clearance. Dosage adjustment in patients with impaired kidney or dialysis.

Before taking Antivic 75 An Thien medicine treats central and peripheral neuropathy (10 blisters x 10 tablets)

How to use

Antivic 75 mg oral, 150 to 600 mg daily is divided into two or three times. Used or not accompanied by food.

Dosage

Neurological pain

Patients may start treating at a dose of 150 mg daily, divided into two or three times. Depending on the response and tolerance of each patient can increase the dose of up to 300 mg per day for a week, if necessary, it can increase to 600mg daily after the next 7 days.

Local epilepsy treatment

The starting dose is 150 mg, oral daily, then gradually increasing the dose after 7 days depending on the response, up to 300 mg/day and then 600 mg/day.

Disseminated anxiety disorders

The dose limit is 150 to 600 mg daily is divided into two or three times. Need to regularly review the needs of treatment.

may start taking antivic 75 mg at a dose of 150 mg daily. Based on the response and tolerance of each patient, adjusting the dose to 300 mg daily after 1 week. After a week of addition, the dose may increase to 450 mg per day. The maximum dose of 600 mg per day can be achieved after a week of addition.

Stop using Pregabalin

According to the current clinical practice, if you have to stop using antivic 75mg, this should be done gradually in at least 1 week regardless of indications.

What to do when overdose? The highest pregabalin dose is recorded as 800 mg does not see significant consequences in clinical.

Overdose: Antivic 75 mg has no specific antidote. If indicated, causing vomiting or gastric lavage, maintain airway as needed. Use measures to reduce symptoms, support patients. Hemolysis is aimed at pregabalin 50% in 4 hours if indicated.

What to do when you forget a dose? However, if close to the next dose, skip the forgotten dose and take the next dose at the time as planned. Note that it should not be used double the prescribed dose.

Side Effects

When using antivic 75 mg, you may experience unwanted effects (ADR).

Common, ADR> 1/100

Nervous system: dizziness, drowsiness, loss of fortune, headache.

Eyes: blurred vision, double look.

Cardiovascular system: peripheral edema.

Digestive system: weight gain, dry mouth.

muscle - bone and connective tissue: muscle tremor, muscle cramps, joint pain, back pain, limb pain, cervical spasm.

other: infection.

Uncommon, 1/1000

Nervous system: neuritis, abnormal thoughts, loss of personality, fatigue, confusion, refreshment, linguistic disorders, attention disorders, loss of movement, loss or loss of memory, pain, dizziness, abnormal sensation or sensory reduction, anxiety, depression, loss of orientation, sleep, fever, stimulating muscle tone.

eyes: visual disorders, vision loss, eyeball vibration, conjunctivitis. ears: hearing loss.

Respiratory: Sinusitis, shortness of breath, bronchitis, sore throat - laryngeal.

Cardiovascular: chest pain, edema. Skin: Facial edema, bruising, itching.

Endocrine and metabolism: stagnant fluid, reducing blood glucose.

stomach - intestines: constipation, appetite, flatulence, vomiting, abdominal pain, gastritis. genital - urinary tract: urine and urinary incontinence, loss of pleasure, sex reduction. Blood: platelets.

muscle - Bone: balancing disorders, abnormal gait, muscle weakness, joint pain, muscle jerky, back pain, muscle spasm, muscle vibration, abnormalities, increased CPK, cramps, muscle pain, muscle weakness.

Other: allergic reactions, influenza syndrome.

Instructions on how to handle ADR

When experiencing side effects of the drug, it is necessary to stop using and notify the doctor or go to the nearest medical facility for timely treatment.

Some ADR causes patients to stop the drug. 4% of patients with dizziness or drowsiness must stop treatment. Most cases are blurred by themselves when they continue to treat, less than 1% of patients have to stop treatment. If visual disorders are prolonged, need for eye exams.

Must stop the drug when muscle disease, or when the serum CPK level increases at least 3 times higher than the normal limit. Must stop the drug when there is weight gain, peripheral edema in people who have heart disease before.

The angioedema rarely occurs, but it usually occurs right after starting therapy Pregabalin; Therefore, before being treated with pregabalin, it is necessary to ask the hypersensory history and prepare the appropriate emergency medium.

In addition, it is necessary to notify the patient and the family about the potential of suicide when taking anti -epileptic drugs. Pay attention to signal symptoms such as anxiety, struggle, aggression, attack, opposition, crazy, insomnia and depression. Families need to closely monitor patients.

When stopping the drug, avoiding sudden stop, gradually reducing the dose for at least a week.

Warnings

Before using the drug you need to read the instructions carefully and refer to the information below.

Contraindicated

Antivic 75 mg is contraindicated to patients with hypersensitivity to the drug and/or any ingredient in the preparation.

Precautions when using

Consulting the opinions of pharmacists, semi -scholars, medical experts before using antivic 75 mg.

Some patients using pregabalin have reported suspected allergic reactions. These symptoms include swelling of the face, lips, tongue and throat, as well as the skin rash. You need to contact the physician immediately when you have these symptoms.

Be cautious when using antivic 75 mg in older patients because the drug can cause dizziness, drowsiness, thereby increasing the risk of falling.

Antivic 75 mg can cause blurred vision or reduced vision, many cases are temporary. You should immediately notify your doctor if you encounter any vision changes.

Some diabetics patients with weight gain while taking antivic 75 mg may need to change their diabetes medications.

Before taking this medication, you should tell your doctor if you have a history of heart disease. There have been reports on heart failure in some patients when taking pregabalin; These patients are mainly elderly with cardiovascular diseases.

There have been reports on renal function impairment in some patients when taking pregabalin. If you use this medication and see your urination, you should tell your doctor to improve this condition.

Anti -convulsions, including pregabalin, often increases the risk of suicidal thoughts or behaviors. Therefore, it is necessary to closely monitor patients during the period of drug use of depression, the trend of suicide, the change of abnormal behavior and timely notifying the medical staff. When using antivic 75 mg with other drugs that can cause constipation (such as some painkillers), there may be abnormalities of the gastrointestinal tract (for example, constipation, obstruction or intestinal paralysis). Let the doctor know if you have constipation, especially if you are susceptible to this problem. Before taking this medication, you should let your doctor know if you have a history of alcoholism or any abuse or depending on the drug. Do not take more medications than the regulations.

There have been a report on convulsions when using pregabalin or a short time after stopping pregabalin. If you have convulsions, please contact your doctor immediately.

There have been reports on reducing brain function (enhancement) in some patients taking pregabalin when they have other diseases. Let the doctor know if you have a history of any serious pathology, including liver or kidney disease.

There have been reports on shortness of breath. If you have nervous system disorders, respiratory disorders, kidney failure or you over 65 years old, your doctor can give you another medication mode. Contact your doctor if you find it difficult to breathe or shallow.

The ability to drive and operate machinery

Antivic 75 mg can cause dizziness, drowsiness and reduce the ability to focus. You should not drive, operate complicated machines or participate in activities that can lead to other dangers.

Pregnancy

There is no adequate data on pregabalin on pregnant women.

Animal studies have shown toxic effects on fertility. It is unknown about the risk that may occur in humans. Therefore, pregabalin should not be used when pregnant unless the benefits give the mother superior to the risk of the fetus. Should use effective contraception for women of reproductive age.

Breastfeeding period

Pregabalin is excreted in milk in breastfeeding women. Due to the unknown pregabalin of pregabalin, breastfeeding is not recommended for breastfeeding while being treated with pregabalin. When deciding to stop breastfeeding or stop treatment with pregabalin, it is necessary to consider the benefits of breastfeeding with children and the benefits of this drug on the mother.

Drug interaction

because Pregabalin is excreted mainly through urine in the form of unprocessed, negligible amount of metabolic drug ( In Vivo studies, there is no clinical pharmacokinetic interaction between pregabalin and phenytoin, carbamazepin, valproic acid, lamotrigin, gabapentin, lorazepam, oxycodon or ethanol. Pharmacokinetic analysis on each group of objects has shown that oral diabetes treatment drugs, diuretics, insulin, phenobarbital, Tiagabin and Topiramat, have no significant clinical effects on pregabalin clearance speed.

Simultaneous use of pregabalin with oral contraceptives oral norethisteron and/or ethinyl estradiol does not affect the pharmacokinetics stability of both drugs. Pregabalin can affect the effects of ethanol and lorazepam. In controlled clinical trials, many doses of oral Pregabalin combined with oxycodon, Lorazepam or ethanol does not cause any important clinical impact on respiratory activity. Pregabalin seems to increase cognitive disorders and overall movement functions caused by Oxycodon.

After circulating the drug, there were reports on respiratory failure and coma in patients using pregabalin and other central neurological inhibitors. There have been deep reports when circulating about events related to lower gastrointestinal function (for example, intestinal obstruction, obstruction, constipation) when taking pregabalin with drugs that can cause constipation, such as Opioid group analgesic.

There has been no specific research on pharmacological interaction conducted on elderly volunteers.

Storage

Products should be stored in a cool, dry place.

Suitable moisture to avoid oxidation of medicinal substances in the drug.

A suitable temperature from 15-30oC.

Stay out of reach of children.

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