Aphaxan Armephaco drug analgesic, anti -inflammatory (5 blisters x 20 tablets)

Dosage form Box of 5 blisters x 20 tablets
Specifications Ibuprofen, paracetamol
Ingredient Fever, headache, dysmenorrhea, cold, back pain, headache after trauma, inflammation, toothache, muscle spasm

Ingredient

Thành phần cho 1 viên

Composition information	Content
Ibuprofen	200mg
Paracetamol	325mg

Uses

Indications 2>

Aphaxan drugs are indicated in the following cases:

Treatment of pain relief, anti -inflammatory in cases of joint pain caused by trauma, rheumatism, neuritis such as back pain, neck scoliosis, sprain, excessive muscle tension, fracture, dislocated, postoperative pain.

Paracetamol (acetaminophen or N - acetyl - P - Aminophenol) is a metabolic substance with the activity of phenacetin, an effective analgesic and antipyretic. Paracetamol reduces body temperature in fever, but rarely reduces body temperature in normal people. The drug affects the hypothalamus causing cooling, increasing heat due to vasodilation and increased peripheral blood flow.

paracetamol, with treatment, less impact on the cardiovascular and respiratory system, does not change acid -base balance, does not cause irritation, scratches or stomach bleeding as when using salicylate, because paracetamol does not work on the whole body cycloxygenase, only affect cycloxygenase/prostaglandin of the central nervous system. Paracetamol does not work on platelets or bleeding time.

When an overdose of paracetamol, a metabolic substance is N - Acetyl - Benzoquinonimin that is toxic to the liver. Normal dose, paracetamol well tolerated. However, acute overdose (over 10 g) causes liver damage to death.

ibuprofen

ibuprofen is an anti -steroid anti -inflammatory drug, derived from propionic acid. Ibuprofen has an analgesic, antipyretic and anti -inflammatory effect. The mechanism of action of the drug is Prostaglandin Synthetase inhibitors and thus prevents producing prostaglandin, thromboxan and other products of cyclooxygenase.

ibuprofen also inhibits prostacyclin synthesis in the kidneys and may cause water stasis due to reducing blood flow to the kidneys. This should be concerned with patients with renal failure, heart failure, liver failure and disorders with plasma volume disorders.

Ibuprofen's anti -inflammatory effects appear after 2 days of treatment. Ibuprofen has a stronger antipyretic effect than aspirin, less indomethacin. The drug has good anti -inflammatory effects and has good analgesic effect in the treatment of teenagers.

Dynamic pharmacokinetics

paracetamol

Paracetamol is quickly absorbed and almost completely through the gastrointestinal tract. Carbon hydrate -rich foods reduce the absorption rate of paracetamol. The peak concentration of plasma is within 30 to 60 minutes after drinking with the dose of treatment.

Paracetamol is distributed quickly and evenly in most body tissues. About 25% paracetamol in the blood combined with plasma proteins.

Paracetamol's plasma disposal time is 1.25 - 3 hours, which can last for toxic doses or in patients with liver damage. After the treatment dose, 90 to 100%of the urine can be found on the first day, mainly after the liver combination with glucuronic acid (about 60%), sulfuric acid (about 35%) or cysteine (about 3%); It also detects a small amount of hydroxyl metabolites - chemicals and reducing acetyl. Young children are less likely to be more in line with the drug than adults.

paracetamol is n - hydroxylation by cytochrome P450 to create N - Acetyl - Benzoquinonimin, an intermediate reaction. This metabolic substance normally reacts with sulfhydryl groups in glutathion and thus is dedicated. However, if taking high doses of paracetamol, this metabolic is formed in sufficient amount to exhaust the glutathion of the liver; In this situation, its reaction to the sulfhydryl group of liver protein increases, which can lead to liver necrosis.

ibuprofen

ibuprofen absorbs well in the digestive tract. The maximum concentration of the drug in plasma is achieved after 1 to 2 hours. The drug is highly attached to plasma proteins. The sale time of the drug is about 2 hours. Ibuprofen eliminates very quickly through the urine (1% in constant form, 14% in the form of combined).

Before taking Aphaxan Armephaco drug analgesic, anti -inflammatory (5 blisters x 20 tablets)

How to use

Take after meals.

Dosage

Following the instructions of the physician or the average dose for adults is:

Case of acute: 1-2 capsules each time, 3 times a day.

Chronic case: 1 tablet each time, 3 times a day.

Note: The above dose is for reference only. Specific dosage depends on the condition and level of progression of the disease. For a suitable dose, you need to consult a doctor or medical specialist.What to do when using overdose?

Without information.

What to do when you forget 1 dose? If it is nearly time to take the next dose, skip the forgotten dose and take medicine at the next recommended dose. Do not take double dose to compensate for the forgotten dose.

Side Effects

When using Aphaxan, you may experience unwanted effects (ADR).

Common

Fever, fatigue, bloating, nausea, vomiting, headache, dizziness, restlessness, rashes, foreign rash.

rarely

Allergic reactions (especially bronchospasm in patients with asthma), rhinitis, urticaria, abdominal pain, stomach -intestinal bleeding, progressive stomach ulcers, drowsiness, insomnia, tinnitus, visual disorders, reduced hearing time, prolonged blood time, hematuria, kidney disease, kidney toxicity when long -term abuse.

rarely

Edema, internal board, Stevens - Johnson syndrome, hair loss, depression, aseptic meningitis, blurred vision, color disorders, vision loss due to drug poisoning, leukopenia, platelet reduction, neutrophils, eosinophilia, Eosin cells, granulocytosis, anemia, cholecyst vaginal disorders, abnormal liver function probes, cystitis, cysticulitis, cycle, cycle, cycle, cycle, cycle, cysticitis damage.

Instructions on how to handle ADR

When experiencing side effects of the drug, it is necessary to stop using and notify the doctor or go to the nearest medical facility for timely treatment.

Warnings

Before using the drug you need to read the instructions carefully and refer to the information below.

contraindicated

Aphaxan drugs contraindicated in the following cases:

Hypersensitivity to one of the ingredients of the drug.

Stomach ulcer - duodenal development, liver failure or severe kidney failure.

Patients with glucose deficiency - 6 - Phosphate dehydrogenase.

scattered erythema lupus (risk of mild meningitis).

Patients who are being treated with anticoagulant drugs.

Pregnant women in the last 3 months of pregnancy.

Be cautious when using

with paracetamol

Be cautious when using paracetamol in patients with anemia before, because purple blue may not manifest clearly, although there are dangerous high concentrations of methemoglobin in the blood.

Limit the drinking of alcohol due to increasing toxicity to the liver of paracetamol.

With ibuprofen

Be cautious when using ibuprofen for the elderly.

ibuprofen can increase transaminase in the blood, but this transformation is transient and recovered. Visual disorders are as blurred, but it will stop using ibuprofen.

ibuprofen inhibits platelet capacitors, so it can cause prolonged bleeding time.

The ability to drive and operate machinery

Caution when driving a train, vehicle and operating machinery because the drug is at risk of dizziness. Pregnancy

Be careful when taking the drug in the first three months of pregnancy. Absolutely do not use drugs in three months, at the end of pregnancy.

breastfeeding period

Precautions when used for breastfeeding women.

Drug interaction

Interacting with paracetamol

Paracetamol long -dose long -dose drinks slightly increase the anticoagulant effect of COMAARIN and conducting indandion.

Paracetamol has the potential to cause serious antipyretic in patients with simultaneously phenothiazine and cooling therapy.

drink too much and long -term, increasing the risk of paracetamol toxic to the liver.

Anti -seizure drugs (including phenytoin, barbiturat, carbamazepin) that cause enzyme induction in the liver microsom, which can increase the toxic liver toxic of paracetamol due to increased drug conversion into toxic substances to the liver.

Limit the use of paracetamol self -use while taking anti -convulsions or isoniazid because it can increase the toxic liver toxic of paracetamol.

Interaction with ibuprofen

ibuprofen and other nonsteroidal anti -inflammatory drugs increase the side effects of quinolon antibiotics on the central nervous system and can lead to convulsions.

Magnesi Hydroxyd increases the initial absorption of ibuprofen but if used with aluminum hydroxyd, it does not have this effect.

Simultaneously used with other nonsteroidal anti -inflammatory drugs increases the risk of bleeding and ulcers.

ibuprofen increases the toxicity of methotrexate.

ibuprofen can reduce the effect of sodium exit of Furosemid and diuretics.

Storage

The cool place, the temperature does not exceed 30 degrees Celsius, avoiding light.

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