APREVEVE 150MG SANOFI treatment for hypertension (2 blisters x 14 tablets)

Dosage form Box of 2 blisters x 14 tablets
Specifications Irbesartan
Ingredient High blood pressure

Ingredient

Composition information	Content
Irbesartan	150mg

Uses

Indications

April belongs to the Angiotensin - II receptor antagonistic drug group. Angiotensin - II is a substance born by the body, when attached to its receptor in the blood vessels, causing blood vessels. The result is hypertension. April against the attachment of angiotensin - II to this receptor thus relaxed blood vessels and lowered blood pressure.

April slows down the impairment of kidney function in hypertension patients and diabetes type 2.

April is designated for adults to:

Treatment of hypertension (primary hypertension).

Renal protection for patients with type 2 diabetes with hypertension and evidence testing for renal function.

Pharmacokology

Medicine group treatment: Angiotensin II receptor antagonism.

ATC code is C09CA04.

Mechanism of action: Irbesartan is a strong antagonist, oral and selective effect with Angiotensin - II receptor receptor (Type AT1). The drug blocks the entire impact of angiotensin - II through the AT1 receptor intermediaries regardless of the origin or synthetic path of angiotensin - II. Angiotensin - II (AT1) receptor receptor (AT1) increases plasma and angiotensin -II levels, reducing plasma aldosteron levels. Irbesartan has an impact without having to go through metabolites.

Clinical effectiveness

Hypertension:

Irbesartan hypotension with minimal effects on the heart rate. The decrease in blood pressure is tended to go towards the top of the plateau at a dose of over 300mg once/day. Doses of 150 - 300mg once a day, lowering blood pressure measured in the sitting position and measuring in the position lying in the bottom time (meaning 24 hours after taking the drug) The average is 8 - 13/5 - 8mmHg (diastolic blood pressure/diastolic blood pressure) more than when placebo users.

Hypertension of peaks achieved within 3-6 hours after taking the drug and hypotension is maintained for at least 24 hours. In 24 hours of blood pressure lowering 60 - 70% of systolic blood pressure response and peak time in the recommended dose. Dosage 150mg once a day, lowering basal blood pressure and blood pressure for 24 hours similar to the total dose but divided into 2 times/day.

The lowering effect of the blood pressure is evident after 1-2 weeks, with the maximum efficiency appearing at 4-6 weeks after the beginning of treatment. The impact of reducing blood pressure is maintained during long -term treatment. After stopping treatment, blood pressure gradually returns to the original level. No observations of hypertension flushing.

There is no important clinical effect on serum uric acid or excreting uric acid into urine.

Hypertension and kidney disease in patients with type 2 diabetes

Research "Irbesartan on kidney disease due to diabetes" (Irbesartan diabetic nephropathy trial = IDNT) shows that Irbesartan reduces the progression of kidney disease in patients with chronic kidney failure and clinical protein.

Research "The effects of Irbesartan on micronutrients in patients with hypertension with type 2 diabetes 2" (Effects of Irbesartan on microalbuminuria in hypertiative patients with type 2 diabetes mellitus = IRMA 2) shows Irbesartan dose of 300mg slowing down the process of progress leading to the protein of the patient with the protein of the patient with the protein of the patient with the protein of the patient with the protein of the patient with the indicators of the patient with the protein of the patient with the protein of the patient with the protein in the patient with the protein of the patient with the protein of the patient in the indicators of the patient's indicators quantity.

pharmacokinetics

After drinking, Irbesartan is well absorbed: studies on biochemistry absolutely for values of about 60 - 80%. Taking medicine during eating does not significantly affect the bioavailability of Irbesartan. Mounting with plasma proteins is about 96%, not significantly connected to blood cell components. The distribution volume is 53 - 93L. Irbesartan is metabolized by the liver through glucuronide and oxidation.

Peak concentration in plasma is achieved at 1.5 - 2 hours after taking the drug. The half -life of Irbesartan is 11 - 15 hours. The stable state of plasma concentration is achieved after 3 days after starting the drink once a day. No need to adjust the dose in the elderly.

Irbesartan and its metabolites are eliminated through both bile and kidney. Less than 2% of Irbesartan dose is excreted in urine in constant form.

Renal failure: In patients with renal impairment or patients who are hemorrhage, the pharmacokinetics parameters of Irbesartan are not significantly changed. Irbesartan is not excluded by hemorrhage.

Hepatic failure: In patients with mild to moderate cirrhosis, the pharmacokinetic parameters of Irbesartan are not significantly changed. Studies have not been conducted in patients with severe liver failure.

Before taking APREVEVE 150MG SANOFI treatment for hypertension (2 blisters x 14 tablets)

How to use

use by oral. The pill must be swallowed with an appropriate amount of water. April can be taken during or outside meals. You should take the daily dose at the same time of the day. It is important that you use theprovel continuously until the doctor decides to use another treatment.

Dosage

Hypertension patients

The usual dose is 150mg once a day. After that, the dose may increase to 300mg once a day depending on the response of blood pressure.

Patients with hypertension and diabetes type 2 with kidney disease

For patients with hypertension and type 2 diabetes, the maintenance dose of 300mg once a day is suitable for the treatment of kidney disease. The doctor may recommend the lower dosage, especially when the treatment is started in patients who are taking blood, or in patients over 75 years old.

The maximum lowering effect can be achieved within 4-6 weeks after the beginning of treatment.

Children should not use April.

Do not use April for children under 18 years old. If a child swallowed a few pills, he had to see a doctor immediately.

Note: Always follow your doctor's instructions for you. You must ask your doctor or pharmacist if you are not sure.

What to do when using overdose? Experiences in adults taken to a dose of 900mg per day for 8 weeks shows that there is no toxic manifestation. The overdose manifestations are thought because Irbesartan is hypotension and heart rate; Slow heart rate can also be encountered.

There is no specific information about the treatment of too. Patients should be closely monitored, symptomatic treatment and support. The processing depends on the time from taken and the severity of the symptoms. The proposed measures in the overdose treatment include vomiting or gastric lavage, and activated carbon. Irbesartan is not eliminated by hemorrhage.

What to do when you forget 1 dose? Do not take double the dose to compensate for the forgotten dose.

If you have any more questions about using this medication, ask your doctor or pharmacist.

Side Effects

Like all drugs, April can cause unwanted effects, although not everyone has these side effects. Some side effects may be serious and require medical monitoring.

As well as similar drugs, rare skin allergic reactions (rash, urticaria), as well as localized swelling on the face, lips or tongue in patients with Irbesartan oral patients. If you have the above symptoms or shortness of breath, stop using April and see your doctor immediately.

The frequency of the following side effects is determined by the following convention:

Very common: affects at least 1 out of 10 patients or more. Fox:

Very common: for patients with hypertension with type 2 diabetes and kidney disease, blood tests showing an increase in potassium concentration. For patients with hypertension and type 2 diabetes with kidney disease, dizziness when standing up from lying or sitting, lowering blood pressure when standing up from lying or sitting, joint pain or muscle as well as reducing protein in red blood cells (hemoglobin). breast. These adverse side effects are dizzy, headache, taste disorders, chiffon in the ears, cramps, joint aches and muscles, abnormalities of liver function, increased blood potassium concentration, kidney function and inflammation of small blood vessels mainly in the skin. Rarely cases of jaundice (jaundice or white eye). If any side effects become serious, or if you experience the side effects not listed in the prescription of this drug, you need to notify your doctor or pharmacist.

Warnings

Before using the drug you need to read the instructions carefully and refer to the information below.

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If you are allergic to Irbesartan or any ingredients contained in April.

Be cautious when using

let your doctor if you encounter one of the following conditions:

diarrhea or vomiting a lot. In this case, the doctor may give regular blood tests, especially the blood potassium concentration in the case of poor kidney function.

Pregnancy or lactation

Pregnant women:

Need to notify the doctor if you are pregnant, or may be pregnant. Usually the doctor will advise you to stop using April before pregnancy or as soon as you know you are pregnant and will recommend that you take other medication instead of April.

April is not recommended in the first months of pregnancy and is not used when pregnant for more than 3 months, because the drug can be a cause of danger to the baby if the mother takes this medication after the first 3 months of pregnancy.

Women who are breastfeeding:

Need to tell the doctor if you are or start breastfeeding. Do not use April for women who are breastfeeding, and the doctor will choose another treatment direction for you, especially when your child is still born or a short -month.

The ability to drive and operate machinery

There has been no research on the effects on the ability to drive and operate machinery. April does not affect the ability to drive or control machines.

However, during the treatment of hypertension, dizziness or fatigue can sometimes occur. If you have these symptoms, you need to consult your doctor before driving or operating machinery.

Drug interaction

Notice to your doctor or pharmacist that the drugs you are using or medium -sized, including non -prescription drugs.

Usually the April does not interact with other drugs.

Need a blood test if you use:

Potassium supplements.

Alternative salt contains potassium.

Potassium drugs (such as diuretics).

Lithium -containing drugs.

The effect of Irbesartan can be reduced when you take painkillers such as nonsteroidal anti -inflammatory.

Use April with food and drink: April can be taken with or not with food.

Storage

Leave the medicine out of the reach and vision of children.

Do not use overdue drugs indicated on the box and on the blister. Store drugs at temperatures below 30 ° C.

Do not quit smoking into wastewater or family trash. Ask the pharmacist how to cancel the drug no longer used. These treatments help protect the environment.

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