APREVEVE 300mg medicine for hypertension treatment (2 blisters x 14 tablets)

Dosage form Box of 2 blisters x 14 tablets
Specifications Irbesartan
Ingredient High blood pressure

Ingredient

Composition information	Content
Irbesartan	300mg

Uses

indications

April 300mg drug is indicated in the following cases:

Use for adults to:

Treatment of hypertension (primary hypertension). The drug blocks all the effects of Angiotin-LL through the AT1 receptor intermediaries regardless of the origin or synthetic path of Angiotensin-LL. Angiotensin-LL receptor selection (AT1) increases plasma and angiotensin-LL levels, reducing plasma aldosteron levels. Irbesartan has an impact without having to go through metabolites.

Clinical effect:

Hypertension:

Irbesartan lower blood pressure and minimize the heart rate. The decrease in blood pressure is tended to go towards the top of the plateau at a dose of over 300 mg once/day. Doses of 150-300 mg once a day, lowering blood pressure measured in the sitting position and measuring in the posture in the bottom time (meaning 24 hours after taking the drug) The average is 8-13/5-8 mmHg (diastolic blood pressure/diastolic blood pressure) more than when placebo users.

Hypertension of peaks achieved within 3-6 hours after taking the drug and hypotension is maintained for at least 24 hours. In 24 hours of blood pressure lowering 60 - 70% of systolic blood pressure response and peak time in the recommended dose. Dosage 150 mg once a day, lowering basal hypotension and blood pressure for 24 hours similar to the total dose but divided into 2 times/day.

The lowering effect of the blood pressure is evident after 1-2 weeks, with the maximum efficiency appearing at 4-6 weeks after the beginning of treatment. The impact of reducing blood pressure is maintained during long -term treatment. After stopping treatment, blood pressure gradually returns to the original level.

Do not observe the phenomenon of hypertension.

There is no important clinical effect on serum uric acid or excreting uric acid into urine.

Hypertension and kidney disease in patients with diabetes type 2:

Research "Irbesartan on kidney disease due to diabetes" (Irbesartan diabetic nephropathy trial = IDNT) shows that Irbesartan reduces the progression of kidney disease in patients with chronic kidney failure and clinical protein.

Research "The effects of Irbesartan on micronutrients in patients with hypertension with type 2 diabetes" (Effects of Irbesartan on microalbuminuria in hypertiative patients with type 2 diabetes mellitus = IRMA 2) shows Irbesartan dose of 300 mg slow to lead to protein in patients with protein in patients with indicators with patients with indicator quantity.

Dynamic pharmacokinetics

After drinking, Irbesartan is well absorbed: Absolutely used biochemical studies for values of about 60 - 80%. Taking medicine during eating does not significantly affect the bioavailability of Irbesartan. Mounting with plasma proteins is about 96%, not significantly connected to blood cell components. The distribution volume is 53 - 93 liters. Irbesartan is metabolized by the liver through glucuronide and oxidation.

Peak concentration in plasma is achieved at 1.5 - 2 hours after taking the drug. The half -life of Irbesartan is 11 - 15. The stable state of plasma concentration is achieved after 3 days after starting the drink once a day. No need to adjust the dose in the elderly.

Irbesartan and its metabolites are eliminated through both bile and kidney. Less than 2% of Irbesartan dose is excreted in urine in constant form.

Renal failure: In patients with renal impairment or patients who are hemorrhage, the pharmacokinetics parameters of Irbesartan are not significantly changed. Irbesartan is not excluded by hemorrhage.

Hepatic failure: In patients with mild to moderate cirrhosis, the pharmacokinetic parameters of Irbesartan are not significantly changed. Studies have not been conducted in patients with severe liver failure.

Before taking APREVEVE 300mg medicine for hypertension treatment (2 blisters x 14 tablets)

How to use

Used by oral, tablets must be swallowed with an appropriate amount of water. April can be taken during or outside meals. You should take the daily dose at the same time of the day. It is important that you use theprovel continuously until the doctor decides to use another treatment.

Dosage

always follow your doctor's instructions for you. You must ask your doctor or pharmacist if you are not sure.

Patients with hypertension

The usual dose is 150 mg once a day. After that, the dose may increase to 300 mg once a day depending on the response of blood pressure.

Patients with hypertension and diabetes type 2 with kidney disease

For patients with hypertension and type 2 diabetes, taking maintenance dose 300 mg once a day is suitable for the treatment of kidney disease. Treatment.

Children should not use April

Do not use April for children under 18 years old. If a child swallowed a few pills, he had to see a doctor immediately.

If you have any more questions about using this medication, ask your doctor or pharmacist.

Note: The above dose is for reference only. Specific dosage depends on the condition and level of progression of the disease. For a suitable dose, you need to consult a doctor or medical specialist.What do

do when using overdose? Experiences in adults taken to a dose of 900 mg per day for 8 weeks shows no toxic manifestation. The overdose manifestations are thought because Irbesartan is hypotension and heart rate; Slow heart rate can also be encountered.

There is no specific information about the treatment of too. Patients should be closely monitored, symptomatic treatment and support. The processing depends on the time from taken and the severity of the symptoms. The proposed measures in the overdose treatment include vomiting and/or gastric wash, can use activated carbon.

Irbesartan is not excluded by hemorrhage.

What to do when you forget 1 dose? Do not take double the dose to compensate for the forgotten dose.

Side Effects

When using the April 300mg drug, you may experience unwanted effects (ADR).

Like all drugs, April can cause unwanted effects, although not everyone has these side effects. Some side effects may be serious and require medical monitoring.

As well as similar drugs, rare skin allergic reactions (rash, urticaria), as well as localized swelling on the face, lips and/or tongue in patients with Irbesartan oral patients. If you have the above symptoms or shortness of breath, stop using April and see your doctor immediately.

The frequency of the following side effects is determined by the following convention:

Very common: affects at least 1 out of 10 patients or more. Fox:

Very common: for patients with hypertension with type 2 diabetes and kidney disease, blood tests showing an increase in potassium concentration. For patients with hypertension and type 2 diabetes with kidney disease, dizziness when standing up from lying or sitting, lowering blood pressure when standing up from lying or sitting position), joint pain or muscles as well as reducing protein in red blood cells (hemoglobin).

Some side effects have been reported since April circulating in the market but unknown frequency. These adverse side effects are dizzy, headache, taste disorders, chiffon in the ears, cramps, joint aches and muscles, abnormalities of liver function, increased blood potassium concentration, renal function and inflammation of small blood vessels mainly in the skin.

Rarely cases of jaundice (jaundice and/or white eye).

Instructions on how to handle ADR

If any side effects become serious, or if you experience the side effects not listed in the prescription of this drug, you need to notify your doctor or pharmacist.

Warnings

Before using the drug you need to read the instructions carefully and refer to the information below.

Contraindicated

April 300mg drugs in the following cases:

Do not use April:

If you are allergic to Irbesartan or any ingredients contained in April.

Be cautious when using

inform your doctor if you encounter one of the following conditions:

diarrhea or vomiting a lot. In this case, the doctor may give regular blood tests, especially the blood potassium concentration in the case of poor kidney function.

The ability to drive and operate machinery

There has been no research on the effects on the ability to drive and operate machinery. April does not affect the ability to drive or control machines.

However, during the treatment of hypertension, dizziness or fatigue can sometimes occur. If you have these symptoms, you need to consult your doctor before driving or operating machinery.

Pregnancy

Need to notify the doctor if you are pregnant, or may be pregnant. Usually the doctor will advise you to stop taking toovel before pregnancy or as soon as you know you are pregnant and will recommend that you take other medication instead of April.

April is not recommended in the first months of pregnancy and is not used when pregnant for more than 3 months, because the drug can be a cause of danger to the baby if the mother takes this medication after the first 3 months of pregnancy.

Breastfeeding period

Need to tell the doctor if you are or start breastfeeding. Do not use April for women who are breastfeeding, and the doctor will choose another treatment direction for you, especially when your child is still born or a short -month.

Interactive drug

Notice to your doctor or pharmacist that the drugs you are using or medium use, including non -prescription drugs.

Usually the April does not interact with other drugs.

Need a blood test if you use:

Potassium supplements.

The effect of Irbesartan may decrease when you take painkillers such as non -steroid anti -inflammatory.

April can be taken with or not with food.

Storage

Leave the medicine out of the reach and vision of children.

Do not use overdue drugs indicated on the box and on the blister.

Store drugs at temperatures below 30 ° C.

Do not quit smoking into wastewater or family trash. Ask the pharmacist how to cancel the drug no longer used. These treatments help protect the environment.

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