Arbuntec 4 Medisun medicine for short -term treatment from mild pain to medium pain (3 blisters x 10 tablets)

Dosage form Box of 3 blisters x 10 tablets
Specifications Lornoxicam
Ingredient Medisun Pharmaceutical Joint Stock Company

Ingredient

Composition information	Content
Lornoxicam	4mg

Uses

indications

Arbuntec is indicated in short -term treatment from mild to medium pain. Treatment of symptoms of pain in osteoarthritis and rheumatoid arthritis.

Pharmacokology

Lornoxicam (Chlortenoxicam), is a new nonsteroidal anti -inflammatory drug (NSAID) of the Oxicam group, analgesic, anti -inflammatory and antipyretic effect.

Lornoxicam's action mechanism is partly based on the inhibition of prostaglandin synthesis (inhibiting cyclo-oxygenase enzyme).

pharmacokinetics

Lornoxicam is quickly and completely absorbed through the digestive tract.

Maximum concentration achieved after about 1 to 2 hours.

Absolute bioavailability (calculated according to the AUC of Lonoxicam is 90-100%.

The average selling time is 3-4 hours.

Lornoxicam has been found in plasma in its unchanged form and as its hydroxy metabolites. Hydroxy metabolites have no pharmacological effects.

Lornoxicam binds to plasma proteins about 99% and does not depend on the concentration. ”

Lornoxicam is completely metabolized, about 2/3 is eliminated through the liver and 1/3 through the kidney in the form of inactive substances.

Lornoxicam is metabolized by cytochrom P450 2C9.

Before taking Arbuntec 4 Medisun medicine for short -term treatment from mild pain to medium pain (3 blisters x 10 tablets)

How to use

Should take medicine with plenty of water.

Dosage

Dosage of treatment in adults and children over 18 years old.

Treatment of pain: Take 1-2 tablets/time x 2 times/day. Total daily dose should not exceed 4 capsules. The maintenance dose must not exceed 4 capsules daily.

Overdose can cause nausea and vomiting, dizziness, loss of air conditioning, coma and abdominal pain, kidneys, coagulation disorders.

In case of actual overdose or suspicion, drugs must be recovered. Symptomatic treatment and support.

What to do when forgetting the dose?

If you forget a dose, use it as soon as possible. However, if close to the next dose, skip the forgotten dose and take the next dose at the time as planned. Note that it should not be used double the prescribed dose.

Side Effects

Very common, ADR> 1/10

Mild and dizzy headache, nausea, abdominal pain, diarrhea and vomiting.

Common, ADR> 1/100

Central nervous system: depression, insomnia

Eye: conjunctivitis, vision disorders

Neurological: dizziness, tinnitus

liver: increased transaminae

skin: allergic skin reactions such as dermatitis, flushing and itching, angioedema, urticaria

hair loss

joint pain.

Respiratory: Sore throat. Sensory, tremor, visual disorders.

High blood pressure. The manager, difficult to swallow, stomatitis aphthous (ulcer), tongue inflammation.

liver: abnormal liver function

Rare, ADR

Liver damage, hepatitis, jaundice, cholestasis. Cardiovascular mass (see more warning and caution).

Warnings

Contraindicated

ARBUNTEC drug is contraindicated in the following cases:

Patients who are sensitive to any component of the drug. Peptic ulcer or a history of stomach ulcers recurrence.

pregnant or lactating women.

Patients under 18 years old.

Precautions when using

History of stomach ulcers and bleeding, frontal hemorrhage, colon ulcer, Crohn's disease, porphyrin metabolism disorders, hematopoietic disorders, patients with heart function decreased. When treating patients with mild to medium heart function, attention must be paid to the risk of water retention and impaired renal function.

Liver disease.

Risk of cardiovascular thrombosis:

Non -steroid anti -inflammatory drugs (NSAIDs), non -aspirin, using systemic sugar can increase the risk of cardiovascular thrombosis, including myocardial infarction and stroke, which can lead to death. This risk can appear early in the first few weeks of taking the drug and can increase over time. The risk of cardiovascular thrombosis is recorded mainly at high doses.

Doctors need to periodically evaluate the appearance of cardiovascular events, even if the patient has no previous cardiovascular symptoms. Patients should be warned of symptoms of serious cardiovascular events and need to visit the doctor as soon as they appear.

To minimize the risk of adverse events, it is necessary to use [drug name] at the lowest daily dose effectively in the shortest possible time.

affects the ability to drive and operate machinery

Because the drug does not cause drowsiness, it is possible to use for drivers and operating machinery.

Pregnant and lactating women

Because there is no adequate and controlled research in pregnant women, this drug is not used for pregnant women.

Do not know if Lorcoxicam is excreted through breast milk or not, not for breast -feeding mothers.

Drug interaction

Simultaneous use of lonoxicam and anticoagulant or platelet supply inhibitors: can prolong bleeding time.

Sulphonylure: may increase hypoglycemia.

Other nonsteroidal anti -inflammatory drugs and aspirin: increase the risk of side effects.

Diuretics: Reduce the effectiveness of diuretics, NSAID against diuretic effects Furosemid.

Inhibition of enzyme: The effect of ACE inhibitors can reduce and risk of acute renal failure.

lithium: can lead to an increase in blood lithium concentration and thus the ability to increase side effects.

Avoid simultaneous use.

methotrexate: Increases the concentration of methotrexate in the blood, avoiding simultaneous use,

Digoxin: Reducing the kidney clearance of digoxin.

Cyclosporin: Increased kidney toxicity.

Lornoxicam interacts with induction drugs and enzyme inhibitors CYP2C9 such as phenytoin, amiodaron, miconazole, tranylcypromin and rifampicin.

Storage

Store in closed packaging, avoid moisture, avoid light, at temperatures below 30 ° C.

Other drugs

Disclaimer

Every effort has been made to ensure that the information provided by Drugslib.com is accurate, up-to-date, and complete, but no guarantee is made to that effect. Drug information contained herein may be time sensitive. Drugslib.com information has been compiled for use by healthcare practitioners and consumers in the United States and therefore Drugslib.com does not warrant that uses outside of the United States are appropriate, unless specifically indicated otherwise. Drugslib.com's drug information does not endorse drugs, diagnose patients or recommend therapy. Drugslib.com's drug information is an informational resource designed to assist licensed healthcare practitioners in caring for their patients and/or to serve consumers viewing this service as a supplement to, and not a substitute for, the expertise, skill, knowledge and judgment of healthcare practitioners.

The absence of a warning for a given drug or drug combination in no way should be construed to indicate that the drug or drug combination is safe, effective or appropriate for any given patient. Drugslib.com does not assume any responsibility for any aspect of healthcare administered with the aid of information Drugslib.com provides. The information contained herein is not intended to cover all possible uses, directions, precautions, warnings, drug interactions, allergic reactions, or adverse effects. If you have questions about the drugs you are taking, check with your doctor, nurse or pharmacist.